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Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study.

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Title: Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study.
Authors: Schmidt MI (AUTHOR), Duncan BB (AUTHOR), Sharrett AR (AUTHOR), Lindberg G (AUTHOR), Savage PJ (AUTHOR), Offenbacher S (AUTHOR), Azambuja MI (AUTHOR), Tracy RP (AUTHOR), Heiss G (AUTHOR), Schmidt, M I (AUTHOR), Duncan, B B (AUTHOR), Sharrett, A R (AUTHOR), Lindberg, G (AUTHOR), Savage, P J (AUTHOR), Offenbacher, S (AUTHOR), Azambuja, M I (AUTHOR), Tracy, R P (AUTHOR), Heiss, G (AUTHOR)
Source: Lancet. 5/15/1999, Vol. 353 Issue 9165, p1649-1652. 4p.
Abstract: Background: Type 2 diabetes mellitus and atherosclerotic cardiovascular disease have common antecedents. Since markers of inflammation predict coronary heart disease and are raised in patients with type 2 diabetes, we investigated whether they predict whether people will develop type 2 diabetes.Methods: 12,330 men and women, aged 45-64 years, were followed up for a mean of 7 years. We analysed the association between different markers of acute inflammation and subsequent diagnosis of diabetes. In a subgroup of 610 individuals selected originally for an unrelated atherosclerosis case-control study, we also investigated diabetes associations with total sialic acid and orosomucoid, haptoglobin, and alpha1-antitrypsin.Findings: 1335 individuals had a new diagnosis of diabetes. Adjusted odds ratios for developing diabetes for quartile extremes were 1.9 (95% CI 1.6-2.3) for raised white-cell count, 1.3 (1.0-1.5) for low serum albumin, and 1.2 (1.0-1.5) for raised fibrinogen. In the subgroup analysis, individuals with concentrations of orosomucoid and sialic acid of more than the median had odds ratios of 7.9 (2.6-23.7) and 3.7 (1.4-9.8), respectively. Adjustment for body-mass index and waist-to-hip ratio lessened the associations; those for white-cell count (1.5 [1.3-1.8]), orosomucoid (7.1 [2.1-23.7]), and sialic acid (2.8 [1.0-8.1]) remained significant.Interpretation: Markers of inflammation are associated with the development of diabetes in middle-aged adults. Although autoimmunity may partly explain these associations, they probably reflect the pathogenesis of type 2 diabetes. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study.
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  Data: <searchLink fieldCode="AR" term="%22Schmidt+MI%22">Schmidt MI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duncan+BB%22">Duncan BB</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharrett+AR%22">Sharrett AR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindberg+G%22">Lindberg G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savage+PJ%22">Savage PJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Offenbacher+S%22">Offenbacher S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azambuja+MI%22">Azambuja MI</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tracy+RP%22">Tracy RP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heiss+G%22">Heiss G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schmidt%2C+M+I%22">Schmidt, M I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Duncan%2C+B+B%22">Duncan, B B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharrett%2C+A+R%22">Sharrett, A R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindberg%2C+G%22">Lindberg, G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Savage%2C+P+J%22">Savage, P J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Offenbacher%2C+S%22">Offenbacher, S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azambuja%2C+M+I%22">Azambuja, M I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tracy%2C+R+P%22">Tracy, R P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Heiss%2C+G%22">Heiss, G</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/15/1999, Vol. 353 Issue 9165, p1649-1652. 4p.
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  Data: <bold>Background: </bold>Type 2 diabetes mellitus and atherosclerotic cardiovascular disease have common antecedents. Since markers of inflammation predict coronary heart disease and are raised in patients with type 2 diabetes, we investigated whether they predict whether people will develop type 2 diabetes.<bold>Methods: </bold>12,330 men and women, aged 45-64 years, were followed up for a mean of 7 years. We analysed the association between different markers of acute inflammation and subsequent diagnosis of diabetes. In a subgroup of 610 individuals selected originally for an unrelated atherosclerosis case-control study, we also investigated diabetes associations with total sialic acid and orosomucoid, haptoglobin, and alpha1-antitrypsin.<bold>Findings: </bold>1335 individuals had a new diagnosis of diabetes. Adjusted odds ratios for developing diabetes for quartile extremes were 1.9 (95% CI 1.6-2.3) for raised white-cell count, 1.3 (1.0-1.5) for low serum albumin, and 1.2 (1.0-1.5) for raised fibrinogen. In the subgroup analysis, individuals with concentrations of orosomucoid and sialic acid of more than the median had odds ratios of 7.9 (2.6-23.7) and 3.7 (1.4-9.8), respectively. Adjustment for body-mass index and waist-to-hip ratio lessened the associations; those for white-cell count (1.5 [1.3-1.8]), orosomucoid (7.1 [2.1-23.7]), and sialic acid (2.8 [1.0-8.1]) remained significant.<bold>Interpretation: </bold>Markers of inflammation are associated with the development of diabetes in middle-aged adults. Although autoimmunity may partly explain these associations, they probably reflect the pathogenesis of type 2 diabetes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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