Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group.
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| Title: | Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group. |
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| Authors: | Ortqvist A (AUTHOR), Hedlund J (AUTHOR), Burman L (AUTHOR), Elbel E (AUTHOR), Hofer M (AUTHOR), Leinonen M (AUTHOR), Lindblad I (AUTHOR), Sundelof B (AUTHOR), Kalin M (AUTHOR), Swedish Pneumococcal Vaccination Study Group (CORPORATE AUTHOR), Ortqvist, A (AUTHOR), Hedlund, J (AUTHOR), Burman, L A (AUTHOR), Elbel, E (AUTHOR), Höfer, M (AUTHOR), Leinonen, M (AUTHOR), Lindblad, I (AUTHOR), Sundelöf, B (AUTHOR), Kalin, M (AUTHOR) |
| Source: | Lancet. 2/7/1998, Vol. 351 Issue 9100, p399-403. 5p. |
| Abstract: | |
| Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 107266554 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ortqvist+A%22">Ortqvist A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hedlund+J%22">Hedlund J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burman+L%22">Burman L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elbel+E%22">Elbel E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hofer+M%22">Hofer M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leinonen+M%22">Leinonen M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindblad+I%22">Lindblad I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sundelof+B%22">Sundelof B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalin+M%22">Kalin M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Swedish+Pneumococcal+Vaccination+Study+Group%22">Swedish Pneumococcal Vaccination Study Group</searchLink> (CORPORATE AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ortqvist%2C+A%22">Ortqvist, A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hedlund%2C+J%22">Hedlund, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burman%2C+L+A%22">Burman, L A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Elbel%2C+E%22">Elbel, E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Höfer%2C+M%22">Höfer, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leinonen%2C+M%22">Leinonen, M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindblad%2C+I%22">Lindblad, I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sundelöf%2C+B%22">Sundelöf, B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalin%2C+M%22">Kalin, M</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 2/7/1998, Vol. 351 Issue 9100, p399-403. 5p. – Name: Abstract Label: Abstract Group: Ab Data: <bold>Background: </bold>We assessed the effectiveness of a 23-valent pneumococcal vaccine in the prevention of pneumococcal pneumonia and of pneumonia overall in non-immunocompromised middle-aged and elderly people.<bold>Methods: </bold>The prospective, multicentre, double-blind, randomised, placebo-controlled trial was carried out across departments of infectious diseases at six tertiary-care or university hospitals in Sweden. 691 non-immunocompromised patients aged 50-85 years who had been treated as inpatients for community-acquired pneumonia (CAP) were randomly assigned either 23-valent pneumococcal capsular polysaccharide vaccine or placebo (sodium chloride). We used Cox regression models to estimate the relative risks of pneumonia overall and pneumococcal pneumonia for the placebo group compared with the vaccine group.<bold>Findings: </bold>63 (19%) of 339 patients in the vaccine group and 57 (16%) of 352 patients in the placebo group developed a new pneumonia, corresponding to a relative risk over time for the placebo group compared with the vaccine group of 0.83 (95% CI 0.58-1.12, p=0.31). Pneumococcal pneumonia was diagnosed in 16 (4.5%) patients in the placebo group and in 19 (5.6%) in the vaccine group, corresponding to a relative risk for the placebo group of 0.78 (95% CI 0.40-1.51, p=0.45). We found no difference in the death rate between the two study groups.<bold>Interpretation: </bold>The 23-valent pneumococcal polysaccharide vaccine did not prevent pneumonia overall or pneumococcal pneumonia in middle-aged and elderly individuals. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=107266554 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(97)07358-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 399 Titles: – TitleFull: Randomised trial of 23-valent pneumococcal capsular polysaccharide vaccine in prevention of pneumonia in middle-aged and elderly people. Swedish Pneumococcal Vaccination Study Group. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ortqvist A – PersonEntity: Name: NameFull: Hedlund J – PersonEntity: Name: NameFull: Burman L – PersonEntity: Name: NameFull: Elbel E – PersonEntity: Name: NameFull: Hofer M – PersonEntity: Name: NameFull: Leinonen M – PersonEntity: Name: NameFull: Lindblad I – PersonEntity: Name: NameFull: Sundelof B – PersonEntity: Name: NameFull: Kalin M – PersonEntity: Name: NameFull: Swedish Pneumococcal Vaccination Study Group – PersonEntity: Name: NameFull: Ortqvist, A – PersonEntity: Name: NameFull: Hedlund, J – PersonEntity: Name: NameFull: Burman, L A – PersonEntity: Name: NameFull: Elbel, E – PersonEntity: Name: NameFull: Höfer, M – PersonEntity: Name: NameFull: Leinonen, M – PersonEntity: Name: NameFull: Lindblad, I – PersonEntity: Name: NameFull: Sundelöf, B – PersonEntity: Name: NameFull: Kalin, M IsPartOfRelationships: – BibEntity: Dates: – D: 07 M: 02 Text: 2/7/1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 351 – Type: issue Value: 9100 Titles: – TitleFull: Lancet Type: main |
| ResultId | 1 |
