Adjuvant portal-vein infusion of fluorouracil and heparin in colorectal cancer: a randomised trial. European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group, the Gruppo Interdisciplinare Valutazione Interventi in Oncologia, and the Japanese Foundation for Cancer Research.

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Title:	Adjuvant portal-vein infusion of fluorouracil and heparin in colorectal cancer: a randomised trial. European Organisation for Research and Treatment of Cancer Gastrointestinal Tract Cancer Cooperative Group, the Gruppo Interdisciplinare Valutazione Interventi in Oncologia, and the Japanese Foundation for Cancer Research.
Authors:	Rougier P (AUTHOR), Sahmoud T (AUTHOR), Nitti D (AUTHOR), Curran D (AUTHOR), Doci R (AUTHOR), De Waele B (AUTHOR), Nakajima T (AUTHOR), Rauschecker H (AUTHOR), Labianca R (AUTHOR), Pector J (AUTHOR), Marsoni S (AUTHOR), Apolone G (AUTHOR), Lasser P (AUTHOR), Couvreur ML (AUTHOR), Wils J (AUTHOR), Rougier, P (AUTHOR), Sahmoud, T (AUTHOR), Nitti, D (AUTHOR), Curran, D (AUTHOR), Doci, R (AUTHOR)
Source:	Lancet. 6/6/1998, Vol. 351 Issue 9117, p1677-1681. 5p.
Abstract:	Background: There is conflicting evidence on the efficacy of regional adjuvant chemotherapy, via portal-vein infusion (PVI), after resection of colorectal cancer. We undertook a randomised controlled multicentre trial to investigate the efficacy of PVI (500 mg/m2 fluorouracil plus 5000 IU heparin daily for 7 days).Methods: 1235 of about 1500 potentially eligible patients were randomly assigned surgery plus PVI or surgery alone (control). The patients were followed up for a median of 63 months, with yearly screening for recurrent disease. The primary endpoint was survival; analyses were by intention to treat.Findings: 619 patients in the control group and 616 in the PVI group met eligibility criteria. 164 (26%) control-group patients and 173 (28%) PVI-group patients died. 5-year survival did not differ significantly between the groups (73 vs 72%; 95% Cl for difference -6 to 4). The control and PVI groups were also similar in terms of disease-free survival at 5 years (67 vs 65%) and the number of patients with liver metastases (79 vs 77%).Interpretation: PVI of fluorouracil, at a dose of 500 mg/m2 for 7 days, cannot be recommended as the sole adjuvant treatment for high-risk colorectal cancer after complete surgical excision. However, these results cannot eliminate a small benefit when PVI is used at a higher dosage or in combination with mitomycin. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection
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