Growth hormone treatment in growth-retarded adolescents after renal transplant.
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| Title: | Growth hormone treatment in growth-retarded adolescents after renal transplant. |
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| Authors: | Hokken-Koelega ACS (AUTHOR), Stijnen T (AUTHOR), de Ridder MAJ (AUTHOR), de Muinck Keizer-Schrama SMP (AUTHOR), Wolff ED (AUTHOR), de Jong MCJ (AUTHOR), Donckerwolcke RA (AUTHOR), Groothoff JW (AUTHOR), Blum WF (AUTHOR), Drop SLS (AUTHOR), Hokken-Koelega, A C (AUTHOR), Stijnen, T (AUTHOR), de Ridder, M A (AUTHOR), de Muinck Keizer-Schrama, S M (AUTHOR), Wolff, E D (AUTHOR), de Jong, M C (AUTHOR), Donckerwolcke, R A (AUTHOR), Groothoff, J W (AUTHOR), Blum, W F (AUTHOR), Drop, S L (AUTHOR) |
| Source: | Lancet. 5/28/1994, Vol. 343 Issue 8909, p1313-1317. 5p. |
| Abstract: | Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15.7 (5.1) cm, significantly greater (p < 0.0001) than in matched controls, 5.8 (3.4) cm. Results were similar for the two GH dosage groups. Bone maturation was not accelerated. Glomerular filtration rate and effective renal plasma flow did not change significantly. The incidence of a > 25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p = 0.97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 107394990 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Growth hormone treatment in growth-retarded adolescents after renal transplant. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hokken-Koelega+ACS%22">Hokken-Koelega ACS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stijnen+T%22">Stijnen T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Ridder+MAJ%22">de Ridder MAJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Muinck+Keizer-Schrama+SMP%22">de Muinck Keizer-Schrama SMP</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wolff+ED%22">Wolff ED</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Jong+MCJ%22">de Jong MCJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donckerwolcke+RA%22">Donckerwolcke RA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Groothoff+JW%22">Groothoff JW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blum+WF%22">Blum WF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Drop+SLS%22">Drop SLS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hokken-Koelega%2C+A+C%22">Hokken-Koelega, A C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stijnen%2C+T%22">Stijnen, T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Ridder%2C+M+A%22">de Ridder, M A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Muinck+Keizer-Schrama%2C+S+M%22">de Muinck Keizer-Schrama, S M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wolff%2C+E+D%22">Wolff, E D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Jong%2C+M+C%22">de Jong, M C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Donckerwolcke%2C+R+A%22">Donckerwolcke, R A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Groothoff%2C+J+W%22">Groothoff, J W</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blum%2C+W+F%22">Blum, W F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Drop%2C+S+L%22">Drop, S L</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 5/28/1994, Vol. 343 Issue 8909, p1313-1317. 5p. – Name: Abstract Label: Abstract Group: Ab Data: Growth failure is a psychosocial problem for many patients who have undergone renal transplantation. 18 adolescents (mean age 15.6, range 11.3-19.5) with severe growth retardation after renal transplantation were treated with biosynthetic growth hormone (GH) for 2 years. All received prednisone, administered daily or on alternate days, with azathioprine and/or cyclosporin A. 16 were blindly assigned to one of two GH doses (4 vs 8 IU per m2 per day). Growth, bone maturation, renal graft function, plasma insulin-like growth factors, serum binding proteins, and other biochemical parameters were checked regularly. Glomerular filtration rate and effective renal plasma flow were tested with 125I-Thalamate and 131I-Hippuran. Data on growth and glomerular filtration rate during GH treatment were also compared with those of matched non-GH-treated controls. Mean (standard deviation) increment in height after 2 years of GH was 15.7 (5.1) cm, significantly greater (p < 0.0001) than in matched controls, 5.8 (3.4) cm. Results were similar for the two GH dosage groups. Bone maturation was not accelerated. Glomerular filtration rate and effective renal plasma flow did not change significantly. The incidence of a > 25% reduction in glomerular filtration rate over 2 years was not significantly higher in GH-treated patients than in non-GH-treated controls (39% vs 32%, p = 0.97). Although a few patients had deterioration of graft function, we could not find a relation with GH treatment. Our results show that sustained improvement of height can be achieved with GH in severely growth-retarded adolescents after renal transplantation. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/s0140-6736(94)92465-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1313 Titles: – TitleFull: Growth hormone treatment in growth-retarded adolescents after renal transplant. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hokken-Koelega ACS – PersonEntity: Name: NameFull: Stijnen T – PersonEntity: Name: NameFull: de Ridder MAJ – PersonEntity: Name: NameFull: de Muinck Keizer-Schrama SMP – PersonEntity: Name: NameFull: Wolff ED – PersonEntity: Name: NameFull: de Jong MCJ – PersonEntity: Name: NameFull: Donckerwolcke RA – PersonEntity: Name: NameFull: Groothoff JW – PersonEntity: Name: NameFull: Blum WF – PersonEntity: Name: NameFull: Drop SLS – PersonEntity: Name: NameFull: Hokken-Koelega, A C – PersonEntity: Name: NameFull: Stijnen, T – PersonEntity: Name: NameFull: de Ridder, M A – PersonEntity: Name: NameFull: de Muinck Keizer-Schrama, S M – PersonEntity: Name: NameFull: Wolff, E D – PersonEntity: Name: NameFull: de Jong, M C – PersonEntity: Name: NameFull: Donckerwolcke, R A – PersonEntity: Name: NameFull: Groothoff, J W – PersonEntity: Name: NameFull: Blum, W F – PersonEntity: Name: NameFull: Drop, S L IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 05 Text: 5/28/1994 Type: published Y: 1994 Identifiers: – Type: issn-print Value: 01406736 Numbering: – Type: volume Value: 343 – Type: issue Value: 8909 Titles: – TitleFull: Lancet Type: main |
| ResultId | 1 |
