Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.
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| Title: | Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review. |
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| Authors: | Azari P (AUTHOR), Lindsay DR (AUTHOR), Briones D (AUTHOR), Clarke C (AUTHOR), Buchheit T (AUTHOR), Pyati S (AUTHOR), Azari, Pari (AUTHOR), Lindsay, David R (AUTHOR), Briones, Dean (AUTHOR), Clarke, Collin (AUTHOR), Buchheit, Thomas (AUTHOR), Pyati, Srinivas (AUTHOR) |
| Source: | CNS Drugs. 2012, Vol. 26 Issue 3, p215-228. 14p. |
| Abstract: | Despite being a recognized clinical entity for over 140 years, complex regional pain syndrome (CRPS) remains a difficult-to-treat condition. While there have been multiple therapies explored in the treatment of CRPS, NMDA antagonists such as ketamine continue to hold significant interest because of their potential ability to alter the central sensitization noted in chronic pain states. The objective of this review is to identify published literature for evidence of the efficacy and safety of ketamine in the treatment of CRPS. PubMed and the Cochrane Controlled Trials Register were searched (final search 26 May 2011) using the MeSH terms 'ketamine', 'complex regional pain syndrome', 'analgesia' and 'pain' in the English literature. The manuscript bibliographies were then reviewed to identify additional relevant papers. Observational trials were evaluated using the Agency for Healthcare Research and Quality criteria; randomized trials were evaluated using the methodological assessment of randomized clinical trials. The search methodology yielded three randomized, placebo-controlled trials, seven observational studies and nine case studies/reports. In aggregate, the data available reveal ketamine as a promising treatment for CRPS. The optimum dose, route and timing of administration remain to be determined. Randomized controlled trials are needed to establish the efficacy and safety of ketamine and to determine its long-term benefit in CRPS. [ABSTRACT FROM AUTHOR] |
| Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 108159437 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Azari+P%22">Azari P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindsay+DR%22">Lindsay DR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Briones+D%22">Briones D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clarke+C%22">Clarke C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buchheit+T%22">Buchheit T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pyati+S%22">Pyati S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Azari%2C+Pari%22">Azari, Pari</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lindsay%2C+David+R%22">Lindsay, David R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Briones%2C+Dean%22">Briones, Dean</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clarke%2C+Collin%22">Clarke, Collin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buchheit%2C+Thomas%22">Buchheit, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pyati%2C+Srinivas%22">Pyati, Srinivas</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22CNS+Drugs%22">CNS Drugs</searchLink>. 2012, Vol. 26 Issue 3, p215-228. 14p. – Name: Abstract Label: Abstract Group: Ab Data: Despite being a recognized clinical entity for over 140 years, complex regional pain syndrome (CRPS) remains a difficult-to-treat condition. While there have been multiple therapies explored in the treatment of CRPS, NMDA antagonists such as ketamine continue to hold significant interest because of their potential ability to alter the central sensitization noted in chronic pain states. The objective of this review is to identify published literature for evidence of the efficacy and safety of ketamine in the treatment of CRPS. PubMed and the Cochrane Controlled Trials Register were searched (final search 26 May 2011) using the MeSH terms 'ketamine', 'complex regional pain syndrome', 'analgesia' and 'pain' in the English literature. The manuscript bibliographies were then reviewed to identify additional relevant papers. Observational trials were evaluated using the Agency for Healthcare Research and Quality criteria; randomized trials were evaluated using the methodological assessment of randomized clinical trials. The search methodology yielded three randomized, placebo-controlled trials, seven observational studies and nine case studies/reports. In aggregate, the data available reveal ketamine as a promising treatment for CRPS. The optimum dose, route and timing of administration remain to be determined. Randomized controlled trials are needed to establish the efficacy and safety of ketamine and to determine its long-term benefit in CRPS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of CNS Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.2165/11595200-000000000-00000 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 215 Titles: – TitleFull: Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Azari P – PersonEntity: Name: NameFull: Lindsay DR – PersonEntity: Name: NameFull: Briones D – PersonEntity: Name: NameFull: Clarke C – PersonEntity: Name: NameFull: Buchheit T – PersonEntity: Name: NameFull: Pyati S – PersonEntity: Name: NameFull: Azari, Pari – PersonEntity: Name: NameFull: Lindsay, David R – PersonEntity: Name: NameFull: Briones, Dean – PersonEntity: Name: NameFull: Clarke, Collin – PersonEntity: Name: NameFull: Buchheit, Thomas – PersonEntity: Name: NameFull: Pyati, Srinivas IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 11727047 Numbering: – Type: volume Value: 26 – Type: issue Value: 3 Titles: – TitleFull: CNS Drugs Type: main |
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