COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL.
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| Title: | COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL. |
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| Authors: | Miller, Shefali, McTeague, Lisa M., Gyurak, Anett, Patenaude, Brian, Williams, Leanne M., Grieve, Stuart M., Korgaonkar, Mayuresh S., Etkin, Amit |
| Source: | Depression & Anxiety (1091-4269). Aug2015, Vol. 32 Issue 8, p594-604. 11p. 2 Charts, 4 Graphs. |
| Subjects: | Cognition in children, Child abuse, Antidepressants, Prediction models, Health outcome assessment, Mental depression |
| Abstract: | Background Childhood maltreatment (CM) history has been associated with poor treatment response in major depressive disorder (MDD), but the mechanisms underlying this relationship remain opaque. Dysfunction in the neural circuits for executive cognition is a putative neurobiological consequence of CM that may contribute importantly to adverse clinical outcomes. We used behavioral and neuroimaging measures of executive functioning to assess their contribution to the relationship between CM and antidepressant response in MDD patients. Methods Ninety eight medication-free MDD outpatients participating in the International Study to Predict Optimized Treatment in Depression were assessed at baseline on behavioral neurocognitive measures and functional magnetic resonance imaging during tasks probing working memory (continuous performance task, CPT) and inhibition (Go/No-go). Seventy seven patients completed 8 weeks of antidepressant treatment. Baseline behavioral and neuroimaging measures were assessed in relation to CM (history of childhood physical, sexual, and/or emotional abuse) and posttreatment depression outcomes. Results Patients with maltreatment exhibited decreased modulation of right dorsolateral prefrontal cortex (DLPFC) activity during working memory updating on the CPT, and a corresponding impairment in CPT behavioral performance outside the scanner. No between-group differences were found for imaging or behavior on the Go/No-go test of inhibition. Greater DLPFC activity during CPT significantly predicted posttreatment symptom improvement in patients without maltreatment, whereas the relationship between DLPFC activity and symptom change was nonsignificant, and in the opposite direction, in patients with maltreatment. Conclusions The effect of CM on prefrontal circuitry involved in executive function is a potential predictor of antidepressant outcomes. [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 108563797 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Miller%2C+Shefali%22">Miller, Shefali</searchLink><br /><searchLink fieldCode="AR" term="%22McTeague%2C+Lisa+M%2E%22">McTeague, Lisa M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gyurak%2C+Anett%22">Gyurak, Anett</searchLink><br /><searchLink fieldCode="AR" term="%22Patenaude%2C+Brian%22">Patenaude, Brian</searchLink><br /><searchLink fieldCode="AR" term="%22Williams%2C+Leanne+M%2E%22">Williams, Leanne M.</searchLink><br /><searchLink fieldCode="AR" term="%22Grieve%2C+Stuart+M%2E%22">Grieve, Stuart M.</searchLink><br /><searchLink fieldCode="AR" term="%22Korgaonkar%2C+Mayuresh+S%2E%22">Korgaonkar, Mayuresh S.</searchLink><br /><searchLink fieldCode="AR" term="%22Etkin%2C+Amit%22">Etkin, Amit</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Aug2015, Vol. 32 Issue 8, p594-604. 11p. 2 Charts, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cognition+in+children%22">Cognition in children</searchLink><br /><searchLink fieldCode="DE" term="%22Child+abuse%22">Child abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Prediction+models%22">Prediction models</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background Childhood maltreatment (CM) history has been associated with poor treatment response in major depressive disorder (MDD), but the mechanisms underlying this relationship remain opaque. Dysfunction in the neural circuits for executive cognition is a putative neurobiological consequence of CM that may contribute importantly to adverse clinical outcomes. We used behavioral and neuroimaging measures of executive functioning to assess their contribution to the relationship between CM and antidepressant response in MDD patients. Methods Ninety eight medication-free MDD outpatients participating in the International Study to Predict Optimized Treatment in Depression were assessed at baseline on behavioral neurocognitive measures and functional magnetic resonance imaging during tasks probing working memory (continuous performance task, CPT) and inhibition (Go/No-go). Seventy seven patients completed 8 weeks of antidepressant treatment. Baseline behavioral and neuroimaging measures were assessed in relation to CM (history of childhood physical, sexual, and/or emotional abuse) and posttreatment depression outcomes. Results Patients with maltreatment exhibited decreased modulation of right dorsolateral prefrontal cortex (DLPFC) activity during working memory updating on the CPT, and a corresponding impairment in CPT behavioral performance outside the scanner. No between-group differences were found for imaging or behavior on the Go/No-go test of inhibition. Greater DLPFC activity during CPT significantly predicted posttreatment symptom improvement in patients without maltreatment, whereas the relationship between DLPFC activity and symptom change was nonsignificant, and in the opposite direction, in patients with maltreatment. Conclusions The effect of CM on prefrontal circuitry involved in executive function is a potential predictor of antidepressant outcomes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/da.22368 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 594 Subjects: – SubjectFull: Cognition in children Type: general – SubjectFull: Child abuse Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Prediction models Type: general – SubjectFull: Health outcome assessment Type: general – SubjectFull: Mental depression Type: general Titles: – TitleFull: COGNITION-CHILDHOOD MALTREATMENT INTERACTIONS IN THE PREDICTION OF ANTIDEPRESSANT OUTCOMES IN MAJOR DEPRESSIVE DISORDER PATIENTS: RESULTS FROM THE iSPOT-D TRIAL. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Miller, Shefali – PersonEntity: Name: NameFull: McTeague, Lisa M. – PersonEntity: Name: NameFull: Gyurak, Anett – PersonEntity: Name: NameFull: Patenaude, Brian – PersonEntity: Name: NameFull: Williams, Leanne M. – PersonEntity: Name: NameFull: Grieve, Stuart M. – PersonEntity: Name: NameFull: Korgaonkar, Mayuresh S. – PersonEntity: Name: NameFull: Etkin, Amit IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 10914269 Numbering: – Type: volume Value: 32 – Type: issue Value: 8 Titles: – TitleFull: Depression & Anxiety (1091-4269) Type: main |
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