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Atherosclerosis in intracranial, extracranial, and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology.

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Title: Atherosclerosis in intracranial, extracranial, and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology.
Authors: Chatzikonstantinou, Anastasios (AUTHOR), Ebert, Anne D. (AUTHOR), Schoenberg, Stefan O. (AUTHOR), Hennerici, Michael G. (AUTHOR), Henzler, Thomas (AUTHOR)
Source: International Journal of Neuroscience. Sep2015, Vol. 125 Issue 9, p663-670. 8p.
Subjects: Atherosclerosis, Atherosclerotic plaque, Ischemia, Stroke patients, Coronary artery stenosis, Etiology of diseases, Patients
Abstract: Objective:We investigated the association of cerebral and coronary artery atherosclerosis with the presence, burden and type of atherosclerotic plaques of the aorta (AP) in patients with ischemic stroke of undetermined etiology.Methods:48 consecutive patients (32 males, mean age 68±11 years) with acute ischemic stroke of unknown etiology after thorough stroke workup were investigated using ECG-gated CT-Angiography (CTA) for the detection of embolic AP. Intima media thickness (IMT), presence of carotid plaques and stenosis ≥50% and intracranial stenosis were assessed as parameters of cerebral atherosclerosis, the Agatston score (AS) and coronary artery stenosis ≥50% (CAS) in CTA as parameters of coronary atherosclerosis. Plaque burden was classified as mild or severe and plaque types were classified according to their morphology in calcified, non-calcified or mixed.Results:APs were found in 36 patients (75%). AP presence was associated with higher IMT values (p= 0.029), intracranial stenosis (p= 0.047), CAS (p= 0.033) and AS (p= 0.026). Twenty-three of 31 (74.2%) patients with both carotid atherosclerosis and AP revealed plaque calcification (p= 0.041). Ten of 14 (71.4%) patients with AP and intracranial stenosis had calcified plaques (p= 0.030). AP in more than one aortic segment was found in patients with bilateral carotid stenosis ≥50% (p= 0.038), intracranial stenosis (p= 0.042), high IMT (p= 0.040) and higher AS (p= 0.019).Conclusions:Aortic atherosclerotic plaques are common in patients with ischemic stroke of undetermined etiology and in particular those with carotid, intracranial and coronary atherosclerosis or high IMT values. In these patients, CTA of aorta should be seriously considered. [ABSTRACT FROM PUBLISHER]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Atherosclerosis in intracranial, extracranial, and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology.
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  Data: <searchLink fieldCode="AR" term="%22Chatzikonstantinou%2C+Anastasios%22">Chatzikonstantinou, Anastasios</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ebert%2C+Anne+D%2E%22">Ebert, Anne D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schoenberg%2C+Stefan+O%2E%22">Schoenberg, Stefan O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hennerici%2C+Michael+G%2E%22">Hennerici, Michael G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Henzler%2C+Thomas%22">Henzler, Thomas</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Sep2015, Vol. 125 Issue 9, p663-670. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Atherosclerosis%22">Atherosclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Atherosclerotic+plaque%22">Atherosclerotic plaque</searchLink><br /><searchLink fieldCode="DE" term="%22Ischemia%22">Ischemia</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+patients%22">Stroke patients</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+artery+stenosis%22">Coronary artery stenosis</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective:We investigated the association of cerebral and coronary artery atherosclerosis with the presence, burden and type of atherosclerotic plaques of the aorta (AP) in patients with ischemic stroke of undetermined etiology.Methods:48 consecutive patients (32 males, mean age 68±11 years) with acute ischemic stroke of unknown etiology after thorough stroke workup were investigated using ECG-gated CT-Angiography (CTA) for the detection of embolic AP. Intima media thickness (IMT), presence of carotid plaques and stenosis ≥50% and intracranial stenosis were assessed as parameters of cerebral atherosclerosis, the Agatston score (AS) and coronary artery stenosis ≥50% (CAS) in CTA as parameters of coronary atherosclerosis. Plaque burden was classified as mild or severe and plaque types were classified according to their morphology in calcified, non-calcified or mixed.Results:APs were found in 36 patients (75%). AP presence was associated with higher IMT values (p= 0.029), intracranial stenosis (p= 0.047), CAS (p= 0.033) and AS (p= 0.026). Twenty-three of 31 (74.2%) patients with both carotid atherosclerosis and AP revealed plaque calcification (p= 0.041). Ten of 14 (71.4%) patients with AP and intracranial stenosis had calcified plaques (p= 0.030). AP in more than one aortic segment was found in patients with bilateral carotid stenosis ≥50% (p= 0.038), intracranial stenosis (p= 0.042), high IMT (p= 0.040) and higher AS (p= 0.019).Conclusions:Aortic atherosclerotic plaques are common in patients with ischemic stroke of undetermined etiology and in particular those with carotid, intracranial and coronary atherosclerosis or high IMT values. In these patients, CTA of aorta should be seriously considered. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3109/00207454.2014.961188
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        Text: English
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        Type: general
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      – SubjectFull: Ischemia
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      – SubjectFull: Stroke patients
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      – SubjectFull: Coronary artery stenosis
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      – SubjectFull: Patients
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    Titles:
      – TitleFull: Atherosclerosis in intracranial, extracranial, and coronary arteries with aortic plaques in patients with ischemic stroke of undetermined etiology.
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              Text: Sep2015
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