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Correlation between Migraine Severity and Cholesterol Levels.

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Title: Correlation between Migraine Severity and Cholesterol Levels.
Authors: Tana, Claudio, Santilli, Francesca, Martelletti, Paolo, Vincenzo, Angelo, Cipollone, Francesco, Davì, Giovanni, Giamberardino, Maria Adele
Source: Pain Practice. Sep2015, Vol. 15 Issue 7, p662-670. 9p. 3 Charts, 4 Graphs.
Subjects: Cardiovascular diseases, Cholesterol, Headache, Migraine, Data analysis software, Descriptive statistics
Abstract: Introduction Several studies have documented increased cardiovascular risk factors, particularly hypercholesterolemia, in the migraine population with respect to controls. However, no studies have investigated the possible relationship between headache severity parameters and lipid serum levels. Methods This study evaluated the lipid asset in 52 migraine patients (17 with and 36 without aura) before and after treatment with drugs for migraine prophylaxis for 3 months. Results High frequency ( HF, ≥ 8/month) and intensity ( HI, ≥ 5 Numeric Rating Score) vs. low frequency ( LF, < 8/month) and intensity ( LI, < 5) of crises were associated with significantly higher cholesterol levels, both total ( TC, HF vs. LF, P < 0.0001; HI vs. LI, P < 0.0001) and LDL ( LDL-c, HF vs. LF, P < 0.0001, and HI vs. LI, P < 0.0001). In treated patients, a significant decrease in number and intensity of crises was associated with a significant reduction of TC and LDL-c ( P < 0.001). A direct linear correlation was also found between frequency and intensity of crises and lipid levels ( TC/frequency, P < 0.0001; TC/intensity, P < 0.0001; LDL-c/frequency, P < 0.0001; LDL-c/intensity, P < 0.0001). No significant difference was found in the evaluated parameters for the subgroups of patients with and without aura. Discussion This study shows a significant positive association between migraine frequency and intensity with total and LDL cholesterol, demonstrating for the first time a significant reduction of these lipid parameters after migraine prophylaxis. However, in view of the retrospective design of the study and the small population size, these results should be considered as preliminary, to be confirmed by future prospective controlled trials. [ABSTRACT FROM AUTHOR]
Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Introduction Several studies have documented increased cardiovascular risk factors, particularly hypercholesterolemia, in the migraine population with respect to controls. However, no studies have investigated the possible relationship between headache severity parameters and lipid serum levels. Methods This study evaluated the lipid asset in 52 migraine patients (17 with and 36 without aura) before and after treatment with drugs for migraine prophylaxis for 3 months. Results High frequency ( HF, ≥ 8/month) and intensity ( HI, ≥ 5 Numeric Rating Score) vs. low frequency ( LF, &lt; 8/month) and intensity ( LI, &lt; 5) of crises were associated with significantly higher cholesterol levels, both total ( TC, HF vs. LF, P &lt; 0.0001; HI vs. LI, P &lt; 0.0001) and LDL ( LDL-c, HF vs. LF, P &lt; 0.0001, and HI vs. LI, P &lt; 0.0001). In treated patients, a significant decrease in number and intensity of crises was associated with a significant reduction of TC and LDL-c ( P &lt; 0.001). A direct linear correlation was also found between frequency and intensity of crises and lipid levels ( TC/frequency, P &lt; 0.0001; TC/intensity, P &lt; 0.0001; LDL-c/frequency, P &lt; 0.0001; LDL-c/intensity, P &lt; 0.0001). No significant difference was found in the evaluated parameters for the subgroups of patients with and without aura. Discussion This study shows a significant positive association between migraine frequency and intensity with total and LDL cholesterol, demonstrating for the first time a significant reduction of these lipid parameters after migraine prophylaxis. However, in view of the retrospective design of the study and the small population size, these results should be considered as preliminary, to be confirmed by future prospective controlled trials. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/papr.12229
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        Text: English
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        Type: general
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      – SubjectFull: Headache
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              Text: Sep2015
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