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Decreasing Hepatitis C Incidence Among a Population With Repeated Tests: British Columbia, Canada, 1993-2011.

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Title: Decreasing Hepatitis C Incidence Among a Population With Repeated Tests: British Columbia, Canada, 1993-2011.
Authors: Kuo, Margot (AUTHOR), Janjua, Naveed Z. (AUTHOR), Burchell, Ann N. (AUTHOR), Buxton, Jane A. (AUTHOR), Krajden, Mel (AUTHOR), Gilbert, Mark (AUTHOR)
Source: American Journal of Public Health. Aug2015, Vol. 105 Issue 8, p1604-1610. 7p.
Subjects: Confidence intervals, Hepatitis C, Medical needs assessment, Research funding, Substance abuse treatment, Treatment programs, Harm reduction, Data analysis software, Descriptive statistics, Odds ratio
Geographic Terms: British Columbia
Abstract: Objectives. We estimated HCV incidence among individuals who repeatedly underwent anti-HCV testing. Methods. We studied HCV-negative individuals who had at least 2 tests between April 1992 and September 2012 in British Columbia, Canada. We calculated incidence as the number of new infections per 100 person-years at risk. Results. From 1992 to 2012, 323 598 individuals who persistently tested negative and 7490 HCV seroconverters contributed 1774 262 person-years of observation time. Incidence rates ranged from 2.66 infections per 100 person-years (95% confidence interval [CI] = 2.07, 3.35) in 1993 to 0.25 infections per 100 person-years (95% CI = 0.21, 0.29) in 2011. Rates declined sharply in the 1990s and declined more gradually in the 2000s. Incidence declined with age; highest incidence rates were among those aged 15 to 24 years. Incidence among male repeat testers exceeded that of female repeat testers across all years, although the gap narrowed overtime. Conclusions. Addictions treatment, harm reduction, prevention education, and novel initiatives to remove barriers in health infrastructure need to be intensified for those who inject drugs, particularly men and younger persons. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Decreasing Hepatitis C Incidence Among a Population With Repeated Tests: British Columbia, Canada, 1993-2011.
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  Data: <searchLink fieldCode="AR" term="%22Kuo%2C+Margot%22">Kuo, Margot</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Janjua%2C+Naveed+Z%2E%22">Janjua, Naveed Z.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burchell%2C+Ann+N%2E%22">Burchell, Ann N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buxton%2C+Jane+A%2E%22">Buxton, Jane A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krajden%2C+Mel%22">Krajden, Mel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gilbert%2C+Mark%22">Gilbert, Mark</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Public+Health%22">American Journal of Public Health</searchLink>. Aug2015, Vol. 105 Issue 8, p1604-1610. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Hepatitis+C%22">Hepatitis C</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+needs+assessment%22">Medical needs assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse+treatment%22">Substance abuse treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+programs%22">Treatment programs</searchLink><br /><searchLink fieldCode="DE" term="%22Harm+reduction%22">Harm reduction</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22British+Columbia%22">British Columbia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives. We estimated HCV incidence among individuals who repeatedly underwent anti-HCV testing. Methods. We studied HCV-negative individuals who had at least 2 tests between April 1992 and September 2012 in British Columbia, Canada. We calculated incidence as the number of new infections per 100 person-years at risk. Results. From 1992 to 2012, 323 598 individuals who persistently tested negative and 7490 HCV seroconverters contributed 1774 262 person-years of observation time. Incidence rates ranged from 2.66 infections per 100 person-years (95% confidence interval [CI] = 2.07, 3.35) in 1993 to 0.25 infections per 100 person-years (95% CI = 0.21, 0.29) in 2011. Rates declined sharply in the 1990s and declined more gradually in the 2000s. Incidence declined with age; highest incidence rates were among those aged 15 to 24 years. Incidence among male repeat testers exceeded that of female repeat testers across all years, although the gap narrowed overtime. Conclusions. Addictions treatment, harm reduction, prevention education, and novel initiatives to remove barriers in health infrastructure need to be intensified for those who inject drugs, particularly men and younger persons. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of American Journal of Public Health is the property of American Public Health Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.2105/AJPH.2015.302591
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        Text: English
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        PageCount: 7
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    Subjects:
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Hepatitis C
        Type: general
      – SubjectFull: Medical needs assessment
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      – SubjectFull: Research funding
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      – SubjectFull: Substance abuse treatment
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      – SubjectFull: Treatment programs
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      – SubjectFull: Harm reduction
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      – SubjectFull: Data analysis software
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Odds ratio
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      – SubjectFull: British Columbia
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      – TitleFull: Decreasing Hepatitis C Incidence Among a Population With Repeated Tests: British Columbia, Canada, 1993-2011.
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              Text: Aug2015
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