Six deaths linked to concomitant use of buprenorphine and benzodiazepines.
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| Title: | Six deaths linked to concomitant use of buprenorphine and benzodiazepines. |
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| Authors: | Reynaud, Michel, Petit, Georges, Potard, Denis, Courty, Pascal |
| Source: | Addiction. Sep1998, Vol. 93 Issue 9, p1385-1392. 8p. 1 Chart. |
| Subjects: | Buprenorphine, Benzodiazepine abuse |
| Geographic Terms: | France |
| Abstract: | Aims. Buprenorphine at high dosage became available in 1996 for substitution treatment in France. This drug is considered particulary safe and has become widely available in general medical practice. We investigated the possible implication of a buprenorphine-benzodiazepine association in six deaths of known abusers. Design. Full investigation of cause of death was conducted for six drug abusers. Setting. The deaths occurred in two regions of France (Auvergne and Lorraine). Assays were carried out by the Institut de Medecine Legale at Strasbourg, France, one of the few French laboratories equipped to assay buprenorphine. Measurement. First, the blood and urine underwent triple exhaustive screening. Secondly, buprenorphine and norbuprenorphine were analysed in all the autopsy samples by HPLC/MS. Findings. Benzodiazepine-buprenorphine associations were found in every case; no other substances that could account for the death were found. The tissue concentrations were markedly higher than the blood levels. Conclusion. If the number of deaths linked to such drug misuse proves high, it may be necessary to review how buprenorphine is dispensed. [ABSTRACT FROM AUTHOR] |
| Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 1102163 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Six deaths linked to concomitant use of buprenorphine and benzodiazepines. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Reynaud%2C+Michel%22">Reynaud, Michel</searchLink><br /><searchLink fieldCode="AR" term="%22Petit%2C+Georges%22">Petit, Georges</searchLink><br /><searchLink fieldCode="AR" term="%22Potard%2C+Denis%22">Potard, Denis</searchLink><br /><searchLink fieldCode="AR" term="%22Courty%2C+Pascal%22">Courty, Pascal</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Sep1998, Vol. 93 Issue 9, p1385-1392. 8p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Buprenorphine%22">Buprenorphine</searchLink><br /><searchLink fieldCode="DE" term="%22Benzodiazepine+abuse%22">Benzodiazepine abuse</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22France%22">France</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aims. Buprenorphine at high dosage became available in 1996 for substitution treatment in France. This drug is considered particulary safe and has become widely available in general medical practice. We investigated the possible implication of a buprenorphine-benzodiazepine association in six deaths of known abusers. Design. Full investigation of cause of death was conducted for six drug abusers. Setting. The deaths occurred in two regions of France (Auvergne and Lorraine). Assays were carried out by the Institut de Medecine Legale at Strasbourg, France, one of the few French laboratories equipped to assay buprenorphine. Measurement. First, the blood and urine underwent triple exhaustive screening. Secondly, buprenorphine and norbuprenorphine were analysed in all the autopsy samples by HPLC/MS. Findings. Benzodiazepine-buprenorphine associations were found in every case; no other substances that could account for the death were found. The tissue concentrations were markedly higher than the blood levels. Conclusion. If the number of deaths linked to such drug misuse proves high, it may be necessary to review how buprenorphine is dispensed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=1102163 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1360-0443.1998.93913859.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1385 Subjects: – SubjectFull: Buprenorphine Type: general – SubjectFull: Benzodiazepine abuse Type: general – SubjectFull: France Type: general Titles: – TitleFull: Six deaths linked to concomitant use of buprenorphine and benzodiazepines. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Reynaud, Michel – PersonEntity: Name: NameFull: Petit, Georges – PersonEntity: Name: NameFull: Potard, Denis – PersonEntity: Name: NameFull: Courty, Pascal IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 09652140 Numbering: – Type: volume Value: 93 – Type: issue Value: 9 Titles: – TitleFull: Addiction Type: main |
| ResultId | 1 |
