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Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.

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Title: Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.
Authors: Hinson, Andrew M., Wilkerson, Bekka M., Rothman‐Fitts, Ivy, Riggs, Ann T., Stack, Brendan C., Bodenner, Donald L.
Source: Journal of the American Geriatrics Society. Oct2015, Vol. 63 Issue 10, p2070-2073. 4p. 2 Graphs.
Subjects: Calcium, Creatinine, Diphosphonates, Hyperparathyroidism, Parathyroid hormone, T-test (Statistics), Vitamin D, Proton pump inhibitors, Retrospective studies, Descriptive statistics
Abstract: Objectives To measure the effect of proton pump inhibitors ( PPIs), with and without concurrent bisphosphonates, on parathyroid hormone ( PTH), vitamin D, and calcium. Design Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg/ dL) and low vitamin D (<30 ng/ mL) were excluded. Setting Academic geriatric outpatient center in southern midwest. Participants Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements ( N = 80) meeting labeled criteria. Measurements Serum calcium, PTH, vitamin D, and creatinine. Results Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/ mL, P < .001; normal range 10-55 pg/ mL) and lower calcium (9.1 vs 9.4 mg/ dL, P = .02; normal range 8.5-10.5 mg/ dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/ mL, P = .05) and lower calcium (9.2 vs 9.6 mg/ dL, P = .04) than BP therapy only. Conclusion Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Objectives To measure the effect of proton pump inhibitors ( PPIs), with and without concurrent bisphosphonates, on parathyroid hormone ( PTH), vitamin D, and calcium. Design Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg/ dL) and low vitamin D (<30 ng/ mL) were excluded. Setting Academic geriatric outpatient center in southern midwest. Participants Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements ( N = 80) meeting labeled criteria. Measurements Serum calcium, PTH, vitamin D, and creatinine. Results Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/ mL, P < .001; normal range 10-55 pg/ mL) and lower calcium (9.1 vs 9.4 mg/ dL, P = .02; normal range 8.5-10.5 mg/ dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/ mL, P = .05) and lower calcium (9.2 vs 9.6 mg/ dL, P = .04) than BP therapy only. Conclusion Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration. [ABSTRACT FROM AUTHOR]
ISSN:00028614
DOI:10.1111/jgs.13661