View in EDS

Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.

Saved in:
Bibliographic Details
Title: Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.
Authors: Hinson, Andrew M., Wilkerson, Bekka M., Rothman‐Fitts, Ivy, Riggs, Ann T., Stack, Brendan C., Bodenner, Donald L.
Source: Journal of the American Geriatrics Society. Oct2015, Vol. 63 Issue 10, p2070-2073. 4p. 2 Graphs.
Subjects: Calcium, Creatinine, Diphosphonates, Hyperparathyroidism, Parathyroid hormone, T-test (Statistics), Vitamin D, Proton pump inhibitors, Retrospective studies, Descriptive statistics
Abstract: Objectives To measure the effect of proton pump inhibitors ( PPIs), with and without concurrent bisphosphonates, on parathyroid hormone ( PTH), vitamin D, and calcium. Design Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg/ dL) and low vitamin D (<30 ng/ mL) were excluded. Setting Academic geriatric outpatient center in southern midwest. Participants Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements ( N = 80) meeting labeled criteria. Measurements Serum calcium, PTH, vitamin D, and creatinine. Results Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/ mL, P < .001; normal range 10-55 pg/ mL) and lower calcium (9.1 vs 9.4 mg/ dL, P = .02; normal range 8.5-10.5 mg/ dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/ mL, P = .05) and lower calcium (9.2 vs 9.6 mg/ dL, P = .04) than BP therapy only. Conclusion Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 110425640
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hinson%2C+Andrew+M%2E%22&quot;&gt;Hinson, Andrew M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wilkerson%2C+Bekka+M%2E%22&quot;&gt;Wilkerson, Bekka M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rothman‐Fitts%2C+Ivy%22&quot;&gt;Rothman‐Fitts, Ivy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Riggs%2C+Ann+T%2E%22&quot;&gt;Riggs, Ann T.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stack%2C+Brendan+C%2E%22&quot;&gt;Stack, Brendan C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bodenner%2C+Donald+L%2E%22&quot;&gt;Bodenner, Donald L.&lt;/searchLink&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+the+American+Geriatrics+Society%22&quot;&gt;Journal of the American Geriatrics Society&lt;/searchLink&gt;. Oct2015, Vol. 63 Issue 10, p2070-2073. 4p. 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Calcium%22&quot;&gt;Calcium&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Creatinine%22&quot;&gt;Creatinine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diphosphonates%22&quot;&gt;Diphosphonates&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hyperparathyroidism%22&quot;&gt;Hyperparathyroidism&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Parathyroid+hormone%22&quot;&gt;Parathyroid hormone&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22T-test+%28Statistics%29%22&quot;&gt;T-test (Statistics)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vitamin+D%22&quot;&gt;Vitamin D&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Proton+pump+inhibitors%22&quot;&gt;Proton pump inhibitors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retrospective+studies%22&quot;&gt;Retrospective studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Descriptive+statistics%22&quot;&gt;Descriptive statistics&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives To measure the effect of proton pump inhibitors ( PPIs), with and without concurrent bisphosphonates, on parathyroid hormone ( PTH), vitamin D, and calcium. Design Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine &gt;1.3 mg/ dL) and low vitamin D (&lt;30 ng/ mL) were excluded. Setting Academic geriatric outpatient center in southern midwest. Participants Individuals aged 60 and older with concurrent calcium, PTH, vitamin D, and creatinine laboratory measurements ( N = 80) meeting labeled criteria. Measurements Serum calcium, PTH, vitamin D, and creatinine. Results Chronic PPI exposure was associated with statistically significantly higher PTH (65.5 vs 30.3 pg/ mL, P &lt; .001; normal range 10-55 pg/ mL) and lower calcium (9.1 vs 9.4 mg/ dL, P = .02; normal range 8.5-10.5 mg/ dL) than no PPI exposure. Chronic PPI exposure with concurrent BP therapy was associated with statistically significantly higher PTH (65.2 vs 43.4 pg/ mL, P = .05) and lower calcium (9.2 vs 9.6 mg/ dL, P = .04) than BP therapy only. Conclusion Based on the present study, chronic PPI exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral BP administration. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=110425640
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/jgs.13661
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 2070
    Subjects:
      – SubjectFull: Calcium
        Type: general
      – SubjectFull: Creatinine
        Type: general
      – SubjectFull: Diphosphonates
        Type: general
      – SubjectFull: Hyperparathyroidism
        Type: general
      – SubjectFull: Parathyroid hormone
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Vitamin D
        Type: general
      – SubjectFull: Proton pump inhibitors
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
    Titles:
      – TitleFull: Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Hinson, Andrew M.
      – PersonEntity:
          Name:
            NameFull: Wilkerson, Bekka M.
      – PersonEntity:
          Name:
            NameFull: Rothman‐Fitts, Ivy
      – PersonEntity:
          Name:
            NameFull: Riggs, Ann T.
      – PersonEntity:
          Name:
            NameFull: Stack, Brendan C.
      – PersonEntity:
          Name:
            NameFull: Bodenner, Donald L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 10
              Text: Oct2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 00028614
          Numbering:
            – Type: volume
              Value: 63
            – Type: issue
              Value: 10
          Titles:
            – TitleFull: Journal of the American Geriatrics Society
              Type: main
ResultId 1