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Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.

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Title: Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Authors: Sewald, Xaver, Ladinsky, Mark S., Uchil, Pradeep D., Beloor, Jagadish, Ruoxi Pi, Herrmann, Christin, Motamedi, Nasim, Murooka, Thomas T., Brehm, Michael A., Greiner, Dale L., Shultz, Leonard D., Mempel, Thorsten R., Bjorkman, Pamela J., Kumar, Priti, Mothes, Walther
Source: Science (pre-March 2025). 10/30/2015, Vol. 350 Issue 6260, p563-567. 5p.
Subjects: Retroviruses, Infection, Mouse leukemia viruses, HIV, Macrophages, Lymphocytes, Virology, B cells, Charts, diagrams, etc.
Abstract: Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown. Here, we visualize how retroviruses disseminate in secondary lymphoid tissues of living mice. We demonstrate that murine leukemia virus (MLV) and human immunodeficiency virus (HIV) are first captured by sinus-lining macrophages. CD169/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus. MLV-laden macrophages then form long-lived synaptic contacts to trans-infect B-1 cells. Infected B-1 cells subsequently migrate into the lymph node to spread the infection through virological synapses. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
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  Data: <searchLink fieldCode="AR" term="%22Sewald%2C+Xaver%22">Sewald, Xaver</searchLink><br /><searchLink fieldCode="AR" term="%22Ladinsky%2C+Mark+S%2E%22">Ladinsky, Mark S.</searchLink><br /><searchLink fieldCode="AR" term="%22Uchil%2C+Pradeep+D%2E%22">Uchil, Pradeep D.</searchLink><br /><searchLink fieldCode="AR" term="%22Beloor%2C+Jagadish%22">Beloor, Jagadish</searchLink><br /><searchLink fieldCode="AR" term="%22Ruoxi+Pi%22">Ruoxi Pi</searchLink><br /><searchLink fieldCode="AR" term="%22Herrmann%2C+Christin%22">Herrmann, Christin</searchLink><br /><searchLink fieldCode="AR" term="%22Motamedi%2C+Nasim%22">Motamedi, Nasim</searchLink><br /><searchLink fieldCode="AR" term="%22Murooka%2C+Thomas+T%2E%22">Murooka, Thomas T.</searchLink><br /><searchLink fieldCode="AR" term="%22Brehm%2C+Michael+A%2E%22">Brehm, Michael A.</searchLink><br /><searchLink fieldCode="AR" term="%22Greiner%2C+Dale+L%2E%22">Greiner, Dale L.</searchLink><br /><searchLink fieldCode="AR" term="%22Shultz%2C+Leonard+D%2E%22">Shultz, Leonard D.</searchLink><br /><searchLink fieldCode="AR" term="%22Mempel%2C+Thorsten+R%2E%22">Mempel, Thorsten R.</searchLink><br /><searchLink fieldCode="AR" term="%22Bjorkman%2C+Pamela+J%2E%22">Bjorkman, Pamela J.</searchLink><br /><searchLink fieldCode="AR" term="%22Kumar%2C+Priti%22">Kumar, Priti</searchLink><br /><searchLink fieldCode="AR" term="%22Mothes%2C+Walther%22">Mothes, Walther</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 10/30/2015, Vol. 350 Issue 6260, p563-567. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Retroviruses%22">Retroviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Infection%22">Infection</searchLink><br /><searchLink fieldCode="DE" term="%22Mouse+leukemia+viruses%22">Mouse leukemia viruses</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22Macrophages%22">Macrophages</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocytes%22">Lymphocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Virology%22">Virology</searchLink><br /><searchLink fieldCode="DE" term="%22B+cells%22">B cells</searchLink><br /><searchLink fieldCode="DE" term="%22Charts%2C+diagrams%2C+etc%2E%22">Charts, diagrams, etc.</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Dendritic cells can capture and transfer retroviruses in vitro across synaptic cell-cell contacts to uninfected cells, a process called trans-infection. Whether trans-infection contributes to retroviral spread in vivo remains unknown. Here, we visualize how retroviruses disseminate in secondary lymphoid tissues of living mice. We demonstrate that murine leukemia virus (MLV) and human immunodeficiency virus (HIV) are first captured by sinus-lining macrophages. CD169/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus. MLV-laden macrophages then form long-lived synaptic contacts to trans-infect B-1 cells. Infected B-1 cells subsequently migrate into the lymph node to spread the infection through virological synapses. Robust infection in lymph nodes and spleen requires CD169, suggesting that a combination of fluid-based movement followed by CD169-dependent trans-infection can contribute to viral spread. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=110629791
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        Text: English
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        PageCount: 5
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      – SubjectFull: Retroviruses
        Type: general
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      – SubjectFull: Mouse leukemia viruses
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              Text: 10/30/2015
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