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Measures of respiratory function correlate with fatigue in ambulatory persons with multiple sclerosis.

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Title: Measures of respiratory function correlate with fatigue in ambulatory persons with multiple sclerosis.
Authors: Ray, Andrew D. (AUTHOR), Mahoney, Martin C. (AUTHOR), Fisher, Nadine M. (AUTHOR)
Source: Disability & Rehabilitation. Dec2015, Vol. 37 Issue 26, p2407-2412. 6p. 3 Charts.
Subjects: Statistical correlation, Fatigue (Physiology), Multiple sclerosis, Muscle strength, Physical fitness, Research funding, Respiration, Pulmonary function tests, Respiratory muscles, Cross-sectional method, Data analysis software, Descriptive statistics, Disease complications
Abstract: Purpose: This article examines the association between measures of respiratory muscle function and fatigue in individuals with mild-to-moderate disability multiple sclerosis (MS).Methods: This was a cross-sectional study of 37 ambulatory volunteers with MS (28 F/9 M, 52.7 ± 10.2 years, Expanded Disability Status Scale [EDSS] = 3.5 ± 1.9). No patients withdrew from the study. Primary outcome variables included measures of respiratory function: maximal inspiratory (MIP) and expiratory pressures (MEP), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), maximal voluntary ventilation (MVV12); and a self-reported measure of fatigue: the Modified Fatigue Impact Scale (MFIS). Secondary measures included 6-min walking test (6MWT), a timed stair climb, the Short Form (SF)-36, the Epworth Sleepiness Scale and the Physical Activity and Disability Scale (PADS).Results: Significant correlations were shown between expiratory muscle strength (MEP) and the MFIS total (p < 0.03,r = –0.362) and between MEP and physical fatigue scores (p < 0.03,r = –0.360), as well as between MVV12percent predicted (respiratory muscle endurance) and both the 6MWT (p = 0.045,r = 0.346) and the Epworth Sleepiness Scale (p = 0.006,r = 0.447).Conclusions: Respiratory muscle performance is correlated with perceived fatigue (MFIS), whereas respiratory endurance correlated to reductions in physical function and sleep quality among individuals with mild-to-moderate severity MS.Implications for RehabilitationMultiple sclerosis (MS) results in peripheral and respiratory muscle weakness and affected individuals report fatigue as one of their most disabling symptoms.Expiratory muscle strength was correlated with self-reported physical fatigue, while respiratory muscle endurance was correlated with functional performance and sleepiness.Respiratory muscle strength was not correlated with lung spirometry testing.These findings highlight the importance of considering the effects of respiratory muscle weakness when evaluating causes of fatigue among individuals with mild-to-moderate MS. [ABSTRACT FROM AUTHOR]
Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Measures of respiratory function correlate with fatigue in ambulatory persons with multiple sclerosis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ray%2C+Andrew+D%2E%22&quot;&gt;Ray, Andrew D.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mahoney%2C+Martin+C%2E%22&quot;&gt;Mahoney, Martin C.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fisher%2C+Nadine+M%2E%22&quot;&gt;Fisher, Nadine M.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Disability+%26+Rehabilitation%22&quot;&gt;Disability &amp; Rehabilitation&lt;/searchLink&gt;. Dec2015, Vol. 37 Issue 26, p2407-2412. 6p. 3 Charts.
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  Data: Purpose: This article examines the association between measures of respiratory muscle function and fatigue in individuals with mild-to-moderate disability multiple sclerosis (MS).Methods: This was a cross-sectional study of 37 ambulatory volunteers with MS (28 F/9 M, 52.7 &#177; 10.2 years, Expanded Disability Status Scale [EDSS] = 3.5 &#177; 1.9). No patients withdrew from the study. Primary outcome variables included measures of respiratory function: maximal inspiratory (MIP) and expiratory pressures (MEP), forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), maximal voluntary ventilation (MVV12); and a self-reported measure of fatigue: the Modified Fatigue Impact Scale (MFIS). Secondary measures included 6-min walking test (6MWT), a timed stair climb, the Short Form (SF)-36, the Epworth Sleepiness Scale and the Physical Activity and Disability Scale (PADS).Results: Significant correlations were shown between expiratory muscle strength (MEP) and the MFIS total (p &lt; 0.03,r = –0.362) and between MEP and physical fatigue scores (p &lt; 0.03,r = –0.360), as well as between MVV12percent predicted (respiratory muscle endurance) and both the 6MWT (p = 0.045,r = 0.346) and the Epworth Sleepiness Scale (p = 0.006,r = 0.447).Conclusions: Respiratory muscle performance is correlated with perceived fatigue (MFIS), whereas respiratory endurance correlated to reductions in physical function and sleep quality among individuals with mild-to-moderate severity MS.Implications for RehabilitationMultiple sclerosis (MS) results in peripheral and respiratory muscle weakness and affected individuals report fatigue as one of their most disabling symptoms.Expiratory muscle strength was correlated with self-reported physical fatigue, while respiratory muscle endurance was correlated with functional performance and sleepiness.Respiratory muscle strength was not correlated with lung spirometry testing.These findings highlight the importance of considering the effects of respiratory muscle weakness when evaluating causes of fatigue among individuals with mild-to-moderate MS. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Disability &amp; Rehabilitation is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.3109/09638288.2015.1031286
    Languages:
      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 2407
    Subjects:
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Fatigue (Physiology)
        Type: general
      – SubjectFull: Multiple sclerosis
        Type: general
      – SubjectFull: Muscle strength
        Type: general
      – SubjectFull: Physical fitness
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Respiration
        Type: general
      – SubjectFull: Pulmonary function tests
        Type: general
      – SubjectFull: Respiratory muscles
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Disease complications
        Type: general
    Titles:
      – TitleFull: Measures of respiratory function correlate with fatigue in ambulatory persons with multiple sclerosis.
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            NameFull: Ray, Andrew D.
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            NameFull: Mahoney, Martin C.
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              Text: Dec2015
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              Y: 2015
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              Value: 37
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