In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA.
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| Title: | In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA. |
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| Authors: | Suridjan, I, Pollock, B G, Verhoeff, N P L G, Voineskos, A N, Chow, T, Rusjan, P M, Lobaugh, N J, Houle, S, Mulsant, B H, Mizrahi, R |
| Source: | Molecular Psychiatry. Dec2015, Vol. 20 Issue 12, p1579-1587. 9p. |
| Subjects: | Encephalitis, Alzheimer's disease, Positron emission tomography, Radioligand assay, Genetic polymorphisms |
| Abstract: | Our primary aim was to compare neuroinflammation in cognitively intact control subjects and patients with Alzheimer's disease (AD) by using positron emission tomography (PET) with translocator protein 18kDa (TSPO)-specific radioligand [18F]-FEPPA. [18F]-FEPPA PET scans were acquired on a high-resolution research tomograph in 21 patients with AD (47- 81 years) and 21 control subjects (49-82 years). They were analyzed by using a 2-tissue compartment model with arterial plasma input function. Differences in neuroinflammation, indexed as [18F]-FEPPA binding were compared, adjusting for differences in binding affinity class as determined by a single polymorphism in the TSPO gene (rs6971). In grey matter areas, [18F]-FEPPA was significantly higher in AD compared with healthy control subjects. Large increases were seen in the hippocampus, prefrontal, temporal, parietal and occipital cortex (average Cohen's d= 0.89). Voxel-based analyses confirmed significant clusters of neuroinflammation in the frontal, temporal and parietal cortex in patients with AD. In white matter, [18F]-FEPPA binding was elevated in the posterior limb of the internal capsule, and the cingulum bundle. Higher neuroinflammation in the parietal cortex (r= −0.7, P= 0.005), and posterior limb of the internal capsule (r= −0.8, P=0.001) was associated with poorer visuospatial function. In addition, a higher [18F]-FEPPA binding in the posterior limb of the internal capsule was associated with a greater impairment in language ability (r= −0.7, P=0.004). Elevated neuroinflammation can be detected in AD patients throughout the brain grey and white matter by using [18F]-FEPPA PET. Our results also suggest that neuroinflammation is associated with some cognitive deficits. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 110965935 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [<superscript>18</superscript>F]-FEPPA. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Suridjan%2C+I%22">Suridjan, I</searchLink><br /><searchLink fieldCode="AR" term="%22Pollock%2C+B+G%22">Pollock, B G</searchLink><br /><searchLink fieldCode="AR" term="%22Verhoeff%2C+N+P+L+G%22">Verhoeff, N P L G</searchLink><br /><searchLink fieldCode="AR" term="%22Voineskos%2C+A+N%22">Voineskos, A N</searchLink><br /><searchLink fieldCode="AR" term="%22Chow%2C+T%22">Chow, T</searchLink><br /><searchLink fieldCode="AR" term="%22Rusjan%2C+P+M%22">Rusjan, P M</searchLink><br /><searchLink fieldCode="AR" term="%22Lobaugh%2C+N+J%22">Lobaugh, N J</searchLink><br /><searchLink fieldCode="AR" term="%22Houle%2C+S%22">Houle, S</searchLink><br /><searchLink fieldCode="AR" term="%22Mulsant%2C+B+H%22">Mulsant, B H</searchLink><br /><searchLink fieldCode="AR" term="%22Mizrahi%2C+R%22">Mizrahi, R</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Dec2015, Vol. 20 Issue 12, p1579-1587. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Encephalitis%22">Encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Radioligand+assay%22">Radioligand assay</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Our primary aim was to compare neuroinflammation in cognitively intact control subjects and patients with Alzheimer's disease (AD) by using positron emission tomography (PET) with translocator protein 18kDa (TSPO)-specific radioligand [18F]-FEPPA. [18F]-FEPPA PET scans were acquired on a high-resolution research tomograph in 21 patients with AD (47- 81 years) and 21 control subjects (49-82 years). They were analyzed by using a 2-tissue compartment model with arterial plasma input function. Differences in neuroinflammation, indexed as [18F]-FEPPA binding were compared, adjusting for differences in binding affinity class as determined by a single polymorphism in the TSPO gene (rs6971). In grey matter areas, [18F]-FEPPA was significantly higher in AD compared with healthy control subjects. Large increases were seen in the hippocampus, prefrontal, temporal, parietal and occipital cortex (average Cohen's d= 0.89). Voxel-based analyses confirmed significant clusters of neuroinflammation in the frontal, temporal and parietal cortex in patients with AD. In white matter, [18F]-FEPPA binding was elevated in the posterior limb of the internal capsule, and the cingulum bundle. Higher neuroinflammation in the parietal cortex (r= −0.7, P= 0.005), and posterior limb of the internal capsule (r= −0.8, P=0.001) was associated with poorer visuospatial function. In addition, a higher [18F]-FEPPA binding in the posterior limb of the internal capsule was associated with a greater impairment in language ability (r= −0.7, P=0.004). Elevated neuroinflammation can be detected in AD patients throughout the brain grey and white matter by using [18F]-FEPPA PET. Our results also suggest that neuroinflammation is associated with some cognitive deficits. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2015.1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1579 Subjects: – SubjectFull: Encephalitis Type: general – SubjectFull: Alzheimer's disease Type: general – SubjectFull: Positron emission tomography Type: general – SubjectFull: Radioligand assay Type: general – SubjectFull: Genetic polymorphisms Type: general Titles: – TitleFull: In-vivo imaging of grey and white matter neuroinflammation in Alzheimer's disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Suridjan, I – PersonEntity: Name: NameFull: Pollock, B G – PersonEntity: Name: NameFull: Verhoeff, N P L G – PersonEntity: Name: NameFull: Voineskos, A N – PersonEntity: Name: NameFull: Chow, T – PersonEntity: Name: NameFull: Rusjan, P M – PersonEntity: Name: NameFull: Lobaugh, N J – PersonEntity: Name: NameFull: Houle, S – PersonEntity: Name: NameFull: Mulsant, B H – PersonEntity: Name: NameFull: Mizrahi, R IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 20 – Type: issue Value: 12 Titles: – TitleFull: Molecular Psychiatry Type: main |
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