Safety and Tolerability of Methacholine Challenge in Infants with Recurrent Wheeze.
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| Title: | Safety and Tolerability of Methacholine Challenge in Infants with Recurrent Wheeze. |
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| Authors: | Bez, C. (AUTHOR), Sach, G. (AUTHOR), Jarisch, A. (AUTHOR), Rosewich, M. (AUTHOR), Reichenbach, J. (AUTHOR), Zielen, S. (AUTHOR) |
| Source: | Journal of Asthma. Oct2003, Vol. 40 Issue 7, p795-802. 8p. |
| Subjects: | Wheeze, Pediatric respiratory diseases, Therapeutics |
| Abstract: | Bronchial hyperreactivity (BHR) is a key feature of asthma, but measurement can usually not be achieved in infants with standard lung function tests. We investigated the safety and tolerability of methacholine challenge in infants with recurrent wheezing episodes. 78 methacholine challenges in 51 sedated infants aged 12–36 months with recurrent wheezing episodes were performed. Methacholine challenge was stopped when clinical signs (coughing, wheezing, or cyanosis) or a drop of oxygen saturation (SPO2) of at least 5% or a drop of transcutaneous oxygen tension (PtcO2) of at least 0.8 kPa or an increase of resistance (RrsSO), of 50% by single occlusion technique were observed. Prior to methacholine challenge, all children were symptom-free with a mean SPO2 of 97.4% (SD 1.80%). In 48 cases (61.5%), no clinical sign was observed, 17 (21.8%) coughed, and 13 (16.7%) wheezed. A mean reduction of SPO2 of 5.0% (SD 3.89%) for the entire population was observed. In 15 of 78 cases, a decrease of SPO2 <90% occurred. This SPO2 drop was short-lasting and resolved spontaneously or after bronchodilator inhalation. Infants whose SPO2 dropped <90% showed a greater increase of RrsSO compared to infants who did not drop <90% (133% vs. 65% RrsSO increase, p<0.001). Methacholine challenge, using a combination of clinical observation, monitoring of SPO2 and PtcO2, and airway resistance using the single-occlusion technique, is a safe and tolerable tool to measure the BHR in infants with recurrent wheezing episodes. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11157364 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Safety and Tolerability of Methacholine Challenge in Infants with Recurrent Wheeze. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bez%2C+C%2E%22">Bez, C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sach%2C+G%2E%22">Sach, G.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jarisch%2C+A%2E%22">Jarisch, A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rosewich%2C+M%2E%22">Rosewich, M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reichenbach%2C+J%2E%22">Reichenbach, J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zielen%2C+S%2E%22">Zielen, S.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Oct2003, Vol. 40 Issue 7, p795-802. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Wheeze%22">Wheeze</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatric+respiratory+diseases%22">Pediatric respiratory diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Bronchial hyperreactivity (BHR) is a key feature of asthma, but measurement can usually not be achieved in infants with standard lung function tests. We investigated the safety and tolerability of methacholine challenge in infants with recurrent wheezing episodes. 78 methacholine challenges in 51 sedated infants aged 12–36 months with recurrent wheezing episodes were performed. Methacholine challenge was stopped when clinical signs (coughing, wheezing, or cyanosis) or a drop of oxygen saturation (SPO2) of at least 5% or a drop of transcutaneous oxygen tension (PtcO2) of at least 0.8 kPa or an increase of resistance (RrsSO), of 50% by single occlusion technique were observed. Prior to methacholine challenge, all children were symptom-free with a mean SPO2 of 97.4% (SD 1.80%). In 48 cases (61.5%), no clinical sign was observed, 17 (21.8%) coughed, and 13 (16.7%) wheezed. A mean reduction of SPO2 of 5.0% (SD 3.89%) for the entire population was observed. In 15 of 78 cases, a decrease of SPO2 <90% occurred. This SPO2 drop was short-lasting and resolved spontaneously or after bronchodilator inhalation. Infants whose SPO2 dropped <90% showed a greater increase of RrsSO compared to infants who did not drop <90% (133% vs. 65% RrsSO increase, p<0.001). Methacholine challenge, using a combination of clinical observation, monitoring of SPO2 and PtcO2, and airway resistance using the single-occlusion technique, is a safe and tolerable tool to measure the BHR in infants with recurrent wheezing episodes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11157364 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1081/JAS-120023571 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 795 Subjects: – SubjectFull: Wheeze Type: general – SubjectFull: Pediatric respiratory diseases Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Safety and Tolerability of Methacholine Challenge in Infants with Recurrent Wheeze. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bez, C. – PersonEntity: Name: NameFull: Sach, G. – PersonEntity: Name: NameFull: Jarisch, A. – PersonEntity: Name: NameFull: Rosewich, M. – PersonEntity: Name: NameFull: Reichenbach, J. – PersonEntity: Name: NameFull: Zielen, S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 02770903 Numbering: – Type: volume Value: 40 – Type: issue Value: 7 Titles: – TitleFull: Journal of Asthma Type: main |
| ResultId | 1 |
