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Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory.

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Title: Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory.
Authors: Bonnin, C. M., Reinares, M., Martínez-Arán, A., Balanzá-Martínez, V., Sole, B., Torrent, C., Tabarés-Seisdedos, R., García-Portilla, M. P., Ibáñez, A., Amann, B. L., Arango, C., Ayuso-Mateos, J. L., Crespo, J. M., González-Pinto, A., Colom, F., Vieta, E.
Source: Psychological Medicine. Jan2016, Vol. 46 Issue 2, p291-301. 11p.
Subjects: Bipolar disorder, Therapeutics, Chi-squared test, Cognition, Intelligence tests, Longitudinal method, Neuropsychological tests, Memory, Classification of mental disorders, Research funding, Statistics, Data analysis, Effect sizes (Statistics), Randomized controlled trials, Repeated measures design, Data analysis software, Descriptive statistics, Psychoeducation, One-way analysis of variance
Abstract: Background. Functional remediation is a novel intervention with demonstrated efficacy at improving functional outcome in euthymic bipolar patients. However, in a previous trial no significant changes in neurocognitive measures were detected. The objective of the present analysis was to test the efficacy of this therapy in the enhancement of neuropsychological functions in a subgroup of neurocognitively impaired bipolar patients. Method. A total of 188 out of 239 DSM-IV euthymic bipolar patients performing below two standard deviations from the mean of normative data in any neurocognitive test were included in this subanalysis. Repeated-measures analyses of variance were conducted to assess the impact of the treatment arms [functional remediation, psychoeducation, or treatment as usual (TAU)] on participants' neurocognitive and functional outcomes in the subgroup of neurocognitively impaired patients. Results. Patients receiving functional remediation (n = 56) showed an improvement on delayed free recall when compared with the TAU (n = 63) and psychoeducation (n = 69) groups as shown by the group × time interaction at 6-month follow-up [F2,158 = 3.37, degrees of freedom (df) = 2, p = 0.037]. However, Tukey post-hoc analyses revealed that functional remediation was only superior when compared with TAU (p = 0.04), but not with psychoeducation (p = 0.10). Finally, the patients in the functional remediation group also benefited from the treatment in terms of functional outcome (F2,158 = 4.26, df = 2, p = 0.016). Conclusions. Functional remediation is effective at improving verbal memory and psychosocial functioning in a sample of neurocognitively impaired bipolar patients at 6-month follow-up. Neurocognitive enhancement may be one of the active ingredients of this novel intervention, and, specifically, verbal memory appears to be the most sensitive function that improves with functional remediation. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory.
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  Data: <searchLink fieldCode="AR" term="%22Bonnin%2C+C%2E+M%2E%22">Bonnin, C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Reinares%2C+M%2E%22">Reinares, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Martínez-Arán%2C+A%2E%22">Martínez-Arán, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Balanzá-Martínez%2C+V%2E%22">Balanzá-Martínez, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Sole%2C+B%2E%22">Sole, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Torrent%2C+C%2E%22">Torrent, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Tabarés-Seisdedos%2C+R%2E%22">Tabarés-Seisdedos, R.</searchLink><br /><searchLink fieldCode="AR" term="%22García-Portilla%2C+M%2E+P%2E%22">García-Portilla, M. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Ibáñez%2C+A%2E%22">Ibáñez, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Amann%2C+B%2E+L%2E%22">Amann, B. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Arango%2C+C%2E%22">Arango, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Ayuso-Mateos%2C+J%2E+L%2E%22">Ayuso-Mateos, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Crespo%2C+J%2E+M%2E%22">Crespo, J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22González-Pinto%2C+A%2E%22">González-Pinto, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Colom%2C+F%2E%22">Colom, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Vieta%2C+E%2E%22">Vieta, E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jan2016, Vol. 46 Issue 2, p291-301. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence+tests%22">Intelligence tests</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Classification+of+mental+disorders%22">Classification of mental disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Effect+sizes+%28Statistics%29%22">Effect sizes (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Repeated+measures+design%22">Repeated measures design</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoeducation%22">Psychoeducation</searchLink><br /><searchLink fieldCode="DE" term="%22One-way+analysis+of+variance%22">One-way analysis of variance</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background. Functional remediation is a novel intervention with demonstrated efficacy at improving functional outcome in euthymic bipolar patients. However, in a previous trial no significant changes in neurocognitive measures were detected. The objective of the present analysis was to test the efficacy of this therapy in the enhancement of neuropsychological functions in a subgroup of neurocognitively impaired bipolar patients. Method. A total of 188 out of 239 DSM-IV euthymic bipolar patients performing below two standard deviations from the mean of normative data in any neurocognitive test were included in this subanalysis. Repeated-measures analyses of variance were conducted to assess the impact of the treatment arms [functional remediation, psychoeducation, or treatment as usual (TAU)] on participants' neurocognitive and functional outcomes in the subgroup of neurocognitively impaired patients. Results. Patients receiving functional remediation (n = 56) showed an improvement on delayed free recall when compared with the TAU (n = 63) and psychoeducation (n = 69) groups as shown by the group × time interaction at 6-month follow-up [F2,158 = 3.37, degrees of freedom (df) = 2, p = 0.037]. However, Tukey post-hoc analyses revealed that functional remediation was only superior when compared with TAU (p = 0.04), but not with psychoeducation (p = 0.10). Finally, the patients in the functional remediation group also benefited from the treatment in terms of functional outcome (F2,158 = 4.26, df = 2, p = 0.016). Conclusions. Functional remediation is effective at improving verbal memory and psychosocial functioning in a sample of neurocognitively impaired bipolar patients at 6-month follow-up. Neurocognitive enhancement may be one of the active ingredients of this novel intervention, and, specifically, verbal memory appears to be the most sensitive function that improves with functional remediation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/S0033291715001713
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