Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese.
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| Title: | Aldehyde dehydrogenase 2 polymorphism as a protective factor for intracranial vascular stenosis in ischemic stroke in Han Chinese. |
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| Authors: | Qu, Yun (AUTHOR), Zhang, Hui-long (AUTHOR), Yu, Li-mei (AUTHOR), Sun, Ying (AUTHOR), Wu, Hong-liang (AUTHOR), Chen, Yu-guo (AUTHOR) |
| Source: | International Journal of Neuroscience. Apr2016, Vol. 126 Issue 4, p342-347. 6p. |
| Subjects: | Aldehyde dehydrogenase, Acetaldehyde, Acetic acid, Coronary disease, Magnetic resonance angiography, Polymerase chain reaction |
| Abstract: | Aim: Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that metabolizes acetaldehyde to acetic acid.ALDH2gene polymorphism modifies its activity and the mutation ofALDH2gene has been reported to be associated with the protection against ischemic stroke. However, the potential association of allelic variation ofALDH2with intracranial vascular stenosis and the clinical characteristics of ischemic stroke without coronary artery disease remains unclear.Methods: In this study, ischemic stroke patients were recruited, National Institutes of Health Stroke Scale scores were analyzed, intracranial arterial stenosis were evaluated by magnetic resonance angiography and gene typing ofALDH2was determined by polymerase chain reaction and sequencing.Results: We found that the rate of heavy drinking was significantly lower in theALDH2mutation group (*1/*2and*2/*2) than in wild-type group (*1/*1) (18.6% vs. 38.0%,p= 0.01). Plasma homocysteine (Hcy) levels were significantly different in the two groups (15.45 ± 6.39 vs. 13.14 ± 4.45,p= 0.015). TheALDH2mutation genotype was negatively correlated with severe intracranial vascular stenosis (OR, 0.34;p= 0.002), even after adjustment for high-density lipoprotein cholesterol, Hcy, and heavy drinking (adjusted OR, 0.44;p= 0.03).Conclusion:ALDH2*2could be a protective factor and negative predictor for severe intracranial vascular stenosis in ischemic stroke in Han Chinese. [ABSTRACT FROM PUBLISHER] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Aim: Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that metabolizes acetaldehyde to acetic acid.ALDH2gene polymorphism modifies its activity and the mutation ofALDH2gene has been reported to be associated with the protection against ischemic stroke. However, the potential association of allelic variation ofALDH2with intracranial vascular stenosis and the clinical characteristics of ischemic stroke without coronary artery disease remains unclear.Methods: In this study, ischemic stroke patients were recruited, National Institutes of Health Stroke Scale scores were analyzed, intracranial arterial stenosis were evaluated by magnetic resonance angiography and gene typing ofALDH2was determined by polymerase chain reaction and sequencing.Results: We found that the rate of heavy drinking was significantly lower in theALDH2mutation group (*1/*2and*2/*2) than in wild-type group (*1/*1) (18.6% vs. 38.0%,p= 0.01). Plasma homocysteine (Hcy) levels were significantly different in the two groups (15.45 ± 6.39 vs. 13.14 ± 4.45,p= 0.015). TheALDH2mutation genotype was negatively correlated with severe intracranial vascular stenosis (OR, 0.34;p= 0.002), even after adjustment for high-density lipoprotein cholesterol, Hcy, and heavy drinking (adjusted OR, 0.44;p= 0.03).Conclusion:ALDH2*2could be a protective factor and negative predictor for severe intracranial vascular stenosis in ischemic stroke in Han Chinese. [ABSTRACT FROM PUBLISHER] |
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| ISSN: | 00207454 |
| DOI: | 10.3109/00207454.2015.1017760 |
