Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis.
Saved in:
| Title: | Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. |
|---|---|
| Authors: | Hardingham, Giles E., Do, Kim Q. |
| Source: | Nature Reviews Neuroscience. Feb2016, Vol. 17 Issue 2, p125-134. 10p. 2 Color Photographs, 3 Diagrams. |
| Abstract: | Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through alterations in the brain's excitation-inhibition balance that result in impaired behaviour and cognition. Although the factors that trigger these deficits are diverse, there is increasing evidence that they converge on a common pathological hub that involves NMDA receptor hypofunction and oxidative stress. These factors have been separately linked to schizophrenia pathogenesis, but evidence now suggests that they are mechanistically interdependent and contribute to a common schizophrenia-associated pathology. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 112441954 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hardingham%2C+Giles+E%2E%22">Hardingham, Giles E.</searchLink><br /><searchLink fieldCode="AR" term="%22Do%2C+Kim+Q%2E%22">Do, Kim Q.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Reviews+Neuroscience%22">Nature Reviews Neuroscience</searchLink>. Feb2016, Vol. 17 Issue 2, p125-134. 10p. 2 Color Photographs, 3 Diagrams. – Name: Abstract Label: Abstract Group: Ab Data: Molecular, genetic and pathological evidence suggests that deficits in GABAergic parvalbumin-positive interneurons contribute to schizophrenia pathophysiology through alterations in the brain's excitation-inhibition balance that result in impaired behaviour and cognition. Although the factors that trigger these deficits are diverse, there is increasing evidence that they converge on a common pathological hub that involves NMDA receptor hypofunction and oxidative stress. These factors have been separately linked to schizophrenia pathogenesis, but evidence now suggests that they are mechanistically interdependent and contribute to a common schizophrenia-associated pathology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Reviews Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=112441954 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nrn.2015.19 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 125 Titles: – TitleFull: Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hardingham, Giles E. – PersonEntity: Name: NameFull: Do, Kim Q. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 1471003X Numbering: – Type: volume Value: 17 – Type: issue Value: 2 Titles: – TitleFull: Nature Reviews Neuroscience Type: main |
| ResultId | 1 |
