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Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory.

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Title: Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory.
Authors: Miranda, M. I. (AUTHOR), LaLumiere, R. T. (AUTHOR), Buen, T. V. (AUTHOR), Bermudez‐Rattoni, F. (AUTHOR), McGaugh, J. L. (AUTHOR)
Source: European Journal of Neuroscience. Nov2003, Vol. 18 Issue 9, p2605-2610. 6p.
Subjects: Aversion, Taste, Response inhibition, Noradrenaline
Abstract: In conditioned taste aversion (CTA), a subject learns to associate a novel taste (conditioned stimulus, CS) with visceral malaise (unconditioned stimulus, US). Considerable evidence indicates that the noradrenergic system in the amygdala plays an important role in memory consolidation for emotionally arousing experiences. The specific aim of the present set of experiments was to determine the involvement of noradrenergic activity in the basolateral amygdala (BLA) during the US presentation and consolidation of CTA as well as during the consolidation of a nonaversive/incidental gustatory memory. Selective bilateral microinfusions of the β-adrenergic antagonist propranolol administered into the BLA immediately before intraperitoneal (i.p.) lithium chloride (LiCl) injections disrupted CTA memory. Additionally, propranolol infused into the BLA immediately after a pre-exposure to the saccharin (CS) significantly attenuated latent inhibition. The present findings indicating that alterations in noradrenergic function in the BLA affect taste memory formation, provide additional evidence that the BLA plays a critical role in modulating the consolidation of memory and that the influence is mediated by interactions with other brain regions that support memory for different kinds of experiences. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Blockade of noradrenergic receptors in the basolateral amygdala impairs taste memory.
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  Data: <searchLink fieldCode="AR" term="%22Miranda%2C+M%2E+I%2E%22">Miranda, M. I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22LaLumiere%2C+R%2E+T%2E%22">LaLumiere, R. T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Buen%2C+T%2E+V%2E%22">Buen, T. V.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bermudez‐Rattoni%2C+F%2E%22">Bermudez‐Rattoni, F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McGaugh%2C+J%2E+L%2E%22">McGaugh, J. L.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Nov2003, Vol. 18 Issue 9, p2605-2610. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Aversion%22">Aversion</searchLink><br /><searchLink fieldCode="DE" term="%22Taste%22">Taste</searchLink><br /><searchLink fieldCode="DE" term="%22Response+inhibition%22">Response inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Noradrenaline%22">Noradrenaline</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In conditioned taste aversion (CTA), a subject learns to associate a novel taste (conditioned stimulus, CS) with visceral malaise (unconditioned stimulus, US). Considerable evidence indicates that the noradrenergic system in the amygdala plays an important role in memory consolidation for emotionally arousing experiences. The specific aim of the present set of experiments was to determine the involvement of noradrenergic activity in the basolateral amygdala (BLA) during the US presentation and consolidation of CTA as well as during the consolidation of a nonaversive/incidental gustatory memory. Selective bilateral microinfusions of the β-adrenergic antagonist propranolol administered into the BLA immediately before intraperitoneal (i.p.) lithium chloride (LiCl) injections disrupted CTA memory. Additionally, propranolol infused into the BLA immediately after a pre-exposure to the saccharin (CS) significantly attenuated latent inhibition. The present findings indicating that alterations in noradrenergic function in the BLA affect taste memory formation, provide additional evidence that the BLA plays a critical role in modulating the consolidation of memory and that the influence is mediated by interactions with other brain regions that support memory for different kinds of experiences. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1046/j.1460-9568.2003.03008.x
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      – Code: eng
        Text: English
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      – SubjectFull: Response inhibition
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              Text: Nov2003
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              Y: 2003
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