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The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study.

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Title: The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study.
Authors: Yang, Rui‐rui, Lu, Bo‐cheng, Li, Tao, Du, Yi‐feng, Wang, Xiang, Jia, Yan‐xia
Source: International Journal of Geriatric Psychiatry. Mar2016, Vol. 31 Issue 3, p231-239. 9p.
Subjects: C-reactive protein, Mental depression, Stroke patients, Inflammation, Brain imaging, Analysis of variance, Longitudinal method, Stroke, Time, NIH Stroke Scale, Psychology
Abstract: Objective: A large body of evidence suggests that stroke and depression are accompanied by activation of inflammatory pathways. Thus, the primary purpose of this study was to assess the high-sensitivity C-reactive protein (Hs-CRP) to the presence of post stroke depression (PSD).Methods: Two hundred and twenty-six ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum Hs-CRP levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke.Results: At 6-month, ninety-five patients (42.0%) showed depression at 6 months after admission and in 69 patients (30.5%) this depression was classified as major. In the 69 patients with major depression, our results showed significantly higher Hs-CRP levels (1.54[IQR, 0.79-2.27]mg/dL vs. 0.43[IQR, 0.31-1.27]mg/dL, P<0.0001) at admission than patients without major depression. After adjusting for NIHSS on admission and all other recorded confounders, Hs-CRP still was an independent predicator of PSD with an adjusted OR of 1.339 (95% CI, 1.231-1.456; P<0.001). Further, in our study, we found that an increased risk of PSD was associated with serum Hs-CRP levels ≥0.85mg/dL (adjusted OR 7.830, 95% CI: 4.193-14.620) after adjusting for above recorded confounders.Conclusion: Elevated Hs-CRP serum levels at admission was found to be associated with depression 6-month after stroke, suggesting that these alterations might participate in the pathophysiology of depression symptoms in stroke patients. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Rui‐rui%22&quot;&gt;Yang, Rui‐rui&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lu%2C+Bo‐cheng%22&quot;&gt;Lu, Bo‐cheng&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Tao%22&quot;&gt;Li, Tao&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Du%2C+Yi‐feng%22&quot;&gt;Du, Yi‐feng&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Xiang%22&quot;&gt;Wang, Xiang&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jia%2C+Yan‐xia%22&quot;&gt;Jia, Yan‐xia&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Geriatric+Psychiatry%22&quot;&gt;International Journal of Geriatric Psychiatry&lt;/searchLink&gt;. Mar2016, Vol. 31 Issue 3, p231-239. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22C-reactive+protein%22&quot;&gt;C-reactive protein&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stroke+patients%22&quot;&gt;Stroke patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Inflammation%22&quot;&gt;Inflammation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain+imaging%22&quot;&gt;Brain imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Analysis+of+variance%22&quot;&gt;Analysis of variance&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Longitudinal+method%22&quot;&gt;Longitudinal method&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Stroke%22&quot;&gt;Stroke&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Time%22&quot;&gt;Time&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22NIH+Stroke+Scale%22&quot;&gt;NIH Stroke Scale&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychology%22&quot;&gt;Psychology&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Objective: &lt;/bold&gt;A large body of evidence suggests that stroke and depression are accompanied by activation of inflammatory pathways. Thus, the primary purpose of this study was to assess the high-sensitivity C-reactive protein (Hs-CRP) to the presence of post stroke depression (PSD).&lt;bold&gt;Methods: &lt;/bold&gt;Two hundred and twenty-six ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 6 months. Clinical information was collected. Serum Hs-CRP levels were measured at baseline. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for depression at 6-month after stroke.&lt;bold&gt;Results: &lt;/bold&gt;At 6-month, ninety-five patients (42.0%) showed depression at 6 months after admission and in 69 patients (30.5%) this depression was classified as major. In the 69 patients with major depression, our results showed significantly higher Hs-CRP levels (1.54[IQR, 0.79-2.27]mg/dL vs. 0.43[IQR, 0.31-1.27]mg/dL, P&lt;0.0001) at admission than patients without major depression. After adjusting for NIHSS on admission and all other recorded confounders, Hs-CRP still was an independent predicator of PSD with an adjusted OR of 1.339 (95% CI, 1.231-1.456; P&lt;0.001). Further, in our study, we found that an increased risk of PSD was associated with serum Hs-CRP levels ≥0.85mg/dL (adjusted OR 7.830, 95% CI: 4.193-14.620) after adjusting for above recorded confounders.&lt;bold&gt;Conclusion: &lt;/bold&gt;Elevated Hs-CRP serum levels at admission was found to be associated with depression 6-month after stroke, suggesting that these alterations might participate in the pathophysiology of depression symptoms in stroke patients. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/gps.4315
    Languages:
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        Text: English
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        PageCount: 9
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      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Stroke patients
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Brain imaging
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      – SubjectFull: Analysis of variance
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Stroke
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      – SubjectFull: NIH Stroke Scale
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      – SubjectFull: Psychology
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      – TitleFull: The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study.
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              Text: Mar2016
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