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Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E.

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Title: Broadly targeted CD8+ T cell responses restricted by major histocompatibility complex E.
Authors: Hansen, Scott G., Wu, Helen L., Burwitz, Benjamin J., Hughes, Colette M., Hammond, Katherine B., Ventura, Abigail B., Reed, Jason S., Gilbride, Roxanne M., Ainslie, Emily, Morrow, David W., Ford, Julia C., Selseth, Andrea N., Pathak, Reesab, Malouli, Daniel, Legasse, Alfred W., Axthelm, Michael K., Nelson, Jay A., Gillespie, Geraldine M., Walters, Lucy C., Brackenridge, Simon
Source: Science (pre-March 2025). 2/12/2016, Vol. 351 Issue 6274, p714-720. 7p.
Subjects: T cells, Histocompatibility antigens, CD81 antigen, Killer cells, Amino acids
Abstract: Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E-restricted presentation of highly varied peptide epitopes to CD8ab+ Tcells, at ~4 distinct epitopes per 100 amino acids in all tested antigens. Computational structural analysis revealed that MHC-E provides heterogeneous chemical environments for diverse side-chain interactions within a stable, open binding groove. Because MHC-E is up-regulated to evade NK cell activity in cells infected with HIV, simian immunodeficiency virus, and other persistent viruses, MHC-E-restricted CD8+ Tcell responses have the potential to exploit pathogen immune-evasion adaptations, a capability that might endow these unconventional responses with superior efficacy. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Broadly targeted CD8<superscript>+</superscript> T cell responses restricted by major histocompatibility complex E.
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  Data: <searchLink fieldCode="AR" term="%22Hansen%2C+Scott+G%2E%22">Hansen, Scott G.</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Helen+L%2E%22">Wu, Helen L.</searchLink><br /><searchLink fieldCode="AR" term="%22Burwitz%2C+Benjamin+J%2E%22">Burwitz, Benjamin J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hughes%2C+Colette+M%2E%22">Hughes, Colette M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hammond%2C+Katherine+B%2E%22">Hammond, Katherine B.</searchLink><br /><searchLink fieldCode="AR" term="%22Ventura%2C+Abigail+B%2E%22">Ventura, Abigail B.</searchLink><br /><searchLink fieldCode="AR" term="%22Reed%2C+Jason+S%2E%22">Reed, Jason S.</searchLink><br /><searchLink fieldCode="AR" term="%22Gilbride%2C+Roxanne+M%2E%22">Gilbride, Roxanne M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ainslie%2C+Emily%22">Ainslie, Emily</searchLink><br /><searchLink fieldCode="AR" term="%22Morrow%2C+David+W%2E%22">Morrow, David W.</searchLink><br /><searchLink fieldCode="AR" term="%22Ford%2C+Julia+C%2E%22">Ford, Julia C.</searchLink><br /><searchLink fieldCode="AR" term="%22Selseth%2C+Andrea+N%2E%22">Selseth, Andrea N.</searchLink><br /><searchLink fieldCode="AR" term="%22Pathak%2C+Reesab%22">Pathak, Reesab</searchLink><br /><searchLink fieldCode="AR" term="%22Malouli%2C+Daniel%22">Malouli, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Legasse%2C+Alfred+W%2E%22">Legasse, Alfred W.</searchLink><br /><searchLink fieldCode="AR" term="%22Axthelm%2C+Michael+K%2E%22">Axthelm, Michael K.</searchLink><br /><searchLink fieldCode="AR" term="%22Nelson%2C+Jay+A%2E%22">Nelson, Jay A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gillespie%2C+Geraldine+M%2E%22">Gillespie, Geraldine M.</searchLink><br /><searchLink fieldCode="AR" term="%22Walters%2C+Lucy+C%2E%22">Walters, Lucy C.</searchLink><br /><searchLink fieldCode="AR" term="%22Brackenridge%2C+Simon%22">Brackenridge, Simon</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/12/2016, Vol. 351 Issue 6274, p714-720. 7p.
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  Data: <searchLink fieldCode="DE" term="%22T+cells%22">T cells</searchLink><br /><searchLink fieldCode="DE" term="%22Histocompatibility+antigens%22">Histocompatibility antigens</searchLink><br /><searchLink fieldCode="DE" term="%22CD81+antigen%22">CD81 antigen</searchLink><br /><searchLink fieldCode="DE" term="%22Killer+cells%22">Killer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Major histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical MHC class Ib molecule with limited polymorphism that is primarily involved in the regulation of natural killer (NK) cells. We found that vaccinating rhesus macaques with rhesus cytomegalovirus vectors in which genes Rh157.5 and Rh157.4 are deleted results in MHC-E-restricted presentation of highly varied peptide epitopes to CD8ab+ Tcells, at ~4 distinct epitopes per 100 amino acids in all tested antigens. Computational structural analysis revealed that MHC-E provides heterogeneous chemical environments for diverse side-chain interactions within a stable, open binding groove. Because MHC-E is up-regulated to evade NK cell activity in cells infected with HIV, simian immunodeficiency virus, and other persistent viruses, MHC-E-restricted CD8+ Tcell responses have the potential to exploit pathogen immune-evasion adaptations, a capability that might endow these unconventional responses with superior efficacy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=113225209
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        Value: 10.1126/science.aac9475
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        Text: English
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      – SubjectFull: CD81 antigen
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