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Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function.

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Title: Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function.
Authors: Singer, Bryan F., Guptaroy, Bipasha, Austin, Curtis J., Wohl, Isabella, Lovic, Vedran, Seiler, Jillian L., Vaughan, Roxanne A., Gnegy, Margaret E., Robinson, Terry E., Aragona, Brandon J., Dalley, Jeffrey
Source: European Journal of Neuroscience. Mar2016, Vol. 43 Issue 5, p662-670. 9p. 5 Graphs.
Subjects: Dopamine, Neural transmission, Nucleus accumbens, Cyclic voltammetry, Laboratory rats, Amphetamines
Abstract: Cues (conditioned stimuli; CSs) associated with rewards can come to motivate behavior, but there is considerable individual variation in their ability to do so. For example, a lever- CS that predicts food reward becomes attractive and wanted, and elicits reward-seeking behavior, to a greater extent in some rats ('sign-trackers'; STs) than others ('goal-trackers'; GTs). Variation in dopamine ( DA) neurotransmission in the nucleus accumbens ( NAc) core is thought to contribute to such individual variation. Given that the DA transporter ( DAT) exerts powerful regulation over DA signaling, we characterized the expression and function of the DAT in the accumbens of STs and GTs. STs showed greater DAT surface expression in ventral striatal synaptosomes than GTs, and ex vivo fast-scan cyclic voltammetry recordings of electrically evoked DA release confirmed enhanced DAT function in STs, as indicated by faster DA uptake, specifically in the NAc core. Consistent with this, systemic amphetamine ( AMPH) produced greater inhibition of DA uptake in STs than in GTs. Furthermore, injection of AMPH directly into the NAc core enhanced lever-directed approach in STs, presumably by amplifying the incentive value of the CS, but had no effect on goal-tracking behavior. On the other hand, there were no differences between STs and GTs in electrically-evoked DA release in slices, or in total ventral striatal DA content. We conclude that greater DAT surface expression may facilitate the attribution of incentive salience to discrete reward cues. Investigating this variability in animal sub-populations may help explain why some people abuse drugs while others do not. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Individual variation in incentive salience attribution and accumbens dopamine transporter expression and function.
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  Data: <searchLink fieldCode="AR" term="%22Singer%2C+Bryan+F%2E%22">Singer, Bryan F.</searchLink><br /><searchLink fieldCode="AR" term="%22Guptaroy%2C+Bipasha%22">Guptaroy, Bipasha</searchLink><br /><searchLink fieldCode="AR" term="%22Austin%2C+Curtis+J%2E%22">Austin, Curtis J.</searchLink><br /><searchLink fieldCode="AR" term="%22Wohl%2C+Isabella%22">Wohl, Isabella</searchLink><br /><searchLink fieldCode="AR" term="%22Lovic%2C+Vedran%22">Lovic, Vedran</searchLink><br /><searchLink fieldCode="AR" term="%22Seiler%2C+Jillian+L%2E%22">Seiler, Jillian L.</searchLink><br /><searchLink fieldCode="AR" term="%22Vaughan%2C+Roxanne+A%2E%22">Vaughan, Roxanne A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gnegy%2C+Margaret+E%2E%22">Gnegy, Margaret E.</searchLink><br /><searchLink fieldCode="AR" term="%22Robinson%2C+Terry+E%2E%22">Robinson, Terry E.</searchLink><br /><searchLink fieldCode="AR" term="%22Aragona%2C+Brandon+J%2E%22">Aragona, Brandon J.</searchLink><br /><searchLink fieldCode="AR" term="%22Dalley%2C+Jeffrey%22">Dalley, Jeffrey</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2016, Vol. 43 Issue 5, p662-670. 9p. 5 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+transmission%22">Neural transmission</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleus+accumbens%22">Nucleus accumbens</searchLink><br /><searchLink fieldCode="DE" term="%22Cyclic+voltammetry%22">Cyclic voltammetry</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink>
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  Data: Cues (conditioned stimuli; CSs) associated with rewards can come to motivate behavior, but there is considerable individual variation in their ability to do so. For example, a lever- CS that predicts food reward becomes attractive and wanted, and elicits reward-seeking behavior, to a greater extent in some rats ('sign-trackers'; STs) than others ('goal-trackers'; GTs). Variation in dopamine ( DA) neurotransmission in the nucleus accumbens ( NAc) core is thought to contribute to such individual variation. Given that the DA transporter ( DAT) exerts powerful regulation over DA signaling, we characterized the expression and function of the DAT in the accumbens of STs and GTs. STs showed greater DAT surface expression in ventral striatal synaptosomes than GTs, and ex vivo fast-scan cyclic voltammetry recordings of electrically evoked DA release confirmed enhanced DAT function in STs, as indicated by faster DA uptake, specifically in the NAc core. Consistent with this, systemic amphetamine ( AMPH) produced greater inhibition of DA uptake in STs than in GTs. Furthermore, injection of AMPH directly into the NAc core enhanced lever-directed approach in STs, presumably by amplifying the incentive value of the CS, but had no effect on goal-tracking behavior. On the other hand, there were no differences between STs and GTs in electrically-evoked DA release in slices, or in total ventral striatal DA content. We conclude that greater DAT surface expression may facilitate the attribution of incentive salience to discrete reward cues. Investigating this variability in animal sub-populations may help explain why some people abuse drugs while others do not. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=113527723
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        Value: 10.1111/ejn.13134
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        Text: English
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        Type: general
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      – SubjectFull: Nucleus accumbens
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      – SubjectFull: Laboratory rats
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      – SubjectFull: Amphetamines
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              Text: Mar2016
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