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Adjustment disorder and risk of Parkinson's disease.

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Title: Adjustment disorder and risk of Parkinson's disease.
Authors: Svensson, E., Farkas, D. K., Gradus, J. L., Lash, T. L., Sørensen, H. T.
Source: European Journal of Neurology. Apr2016, Vol. 23 Issue 4, p751-756. 6p.
Subjects: Parkinson's disease, Disease risk factors, Psychological stress, Adjustment disorders, Patients, Pathological psychology
Abstract: Background and purpose It has been postulated that stress is part of the etiological process of Parkinson's disease ( PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event. Methods Using Danish medical registries, PD occurrence was examined in a nationwide population-based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety. Results Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow-up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety. Conclusion Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Adjustment disorder and risk of Parkinson's disease.
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  Data: <searchLink fieldCode="AR" term="%22Svensson%2C+E%2E%22">Svensson, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Farkas%2C+D%2E+K%2E%22">Farkas, D. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Gradus%2C+J%2E+L%2E%22">Gradus, J. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Lash%2C+T%2E+L%2E%22">Lash, T. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Sørensen%2C+H%2E+T%2E%22">Sørensen, H. T.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Apr2016, Vol. 23 Issue 4, p751-756. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Adjustment+disorders%22">Adjustment disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background and purpose It has been postulated that stress is part of the etiological process of Parkinson's disease ( PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event. Methods Using Danish medical registries, PD occurrence was examined in a nationwide population-based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety. Results Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow-up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety. Conclusion Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=113900671
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