View in EDS HTML Full Text PDF Full Text

Voxel-based morphometry study on monozygotic twins discordant for Alzheimer's disease.

Saved in:
Bibliographic Details
Title: Voxel-based morphometry study on monozygotic twins discordant for Alzheimer's disease.
Authors: Rossi, R., Pievani, M., Järvenpää, T., Testa, C., Koskenvuo, M., Räihä, I., Kaprio, J., Frisoni, G. B., Rinne, J. O., Laakso, M. P.
Source: Acta Neurologica Scandinavica. Jun2016, Vol. 133 Issue 6, p427-433. 7p.
Subjects: Alzheimer's disease, Voxel-based morphometry, Morphometrics, Embryology, Gray matter (Nerve tissue)
Abstract: Objectives We set to investigate the possible role of genes and environment in developing Alzheimer's disease ( AD) in monozygotic twin pairs discordant for AD. Methods Three pairs of twins discordant for AD, who were enrolled in the Finnish Twin Cohort, were used in the study and compared with 13 controls. Gray matter changes were assessed with magnetic resonance images using voxel-based morphometry with statistical parametric mapping. Results In the affected twins, the peaks of volume loss were located bilaterally in the temporal (including the hippocampus), the frontal, and the parietal lobes, while in the unaffected siblings, the peaks were located in the frontal gyri and in the parietal lobule. Thus, in the unaffected twins, the pattern of volume loss overlaps with the neocortical but not with the medial temporal areas. Discussion These findings suggest that genetic factors more largely control neocortical regions, whereas environmental factors more strongly affect medial temporal regions. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 114245004
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Voxel-based morphometry study on monozygotic twins discordant for Alzheimer's disease.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Rossi%2C+R%2E%22">Rossi, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Pievani%2C+M%2E%22">Pievani, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Järvenpää%2C+T%2E%22">Järvenpää, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Testa%2C+C%2E%22">Testa, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Koskenvuo%2C+M%2E%22">Koskenvuo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Räihä%2C+I%2E%22">Räihä, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaprio%2C+J%2E%22">Kaprio, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Frisoni%2C+G%2E+B%2E%22">Frisoni, G. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Rinne%2C+J%2E+O%2E%22">Rinne, J. O.</searchLink><br /><searchLink fieldCode="AR" term="%22Laakso%2C+M%2E+P%2E%22">Laakso, M. P.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jun2016, Vol. 133 Issue 6, p427-433. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Voxel-based+morphometry%22">Voxel-based morphometry</searchLink><br /><searchLink fieldCode="DE" term="%22Morphometrics%22">Morphometrics</searchLink><br /><searchLink fieldCode="DE" term="%22Embryology%22">Embryology</searchLink><br /><searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives We set to investigate the possible role of genes and environment in developing Alzheimer's disease ( AD) in monozygotic twin pairs discordant for AD. Methods Three pairs of twins discordant for AD, who were enrolled in the Finnish Twin Cohort, were used in the study and compared with 13 controls. Gray matter changes were assessed with magnetic resonance images using voxel-based morphometry with statistical parametric mapping. Results In the affected twins, the peaks of volume loss were located bilaterally in the temporal (including the hippocampus), the frontal, and the parietal lobes, while in the unaffected siblings, the peaks were located in the frontal gyri and in the parietal lobule. Thus, in the unaffected twins, the pattern of volume loss overlaps with the neocortical but not with the medial temporal areas. Discussion These findings suggest that genetic factors more largely control neocortical regions, whereas environmental factors more strongly affect medial temporal regions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=114245004
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ane.12480
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 427
    Subjects:
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Voxel-based morphometry
        Type: general
      – SubjectFull: Morphometrics
        Type: general
      – SubjectFull: Embryology
        Type: general
      – SubjectFull: Gray matter (Nerve tissue)
        Type: general
    Titles:
      – TitleFull: Voxel-based morphometry study on monozygotic twins discordant for Alzheimer's disease.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Rossi, R.
      – PersonEntity:
          Name:
            NameFull: Pievani, M.
      – PersonEntity:
          Name:
            NameFull: Järvenpää, T.
      – PersonEntity:
          Name:
            NameFull: Testa, C.
      – PersonEntity:
          Name:
            NameFull: Koskenvuo, M.
      – PersonEntity:
          Name:
            NameFull: Räihä, I.
      – PersonEntity:
          Name:
            NameFull: Kaprio, J.
      – PersonEntity:
          Name:
            NameFull: Frisoni, G. B.
      – PersonEntity:
          Name:
            NameFull: Rinne, J. O.
      – PersonEntity:
          Name:
            NameFull: Laakso, M. P.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 133
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1