Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications.
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| Title: | Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications. |
|---|---|
| Authors: | Pollak, T., Beck, K., Irani, S., Howes, O., David, A., McGuire, P. |
| Source: | Psychopharmacology. May2016, Vol. 233 Issue 9, p1605-1621. 17p. |
| Subjects: | Autoantibodies, Central nervous system, Cell surface antigens, Neuron analysis, Mental illness |
| Abstract: | Rationale: Autoantibodies to central nervous system (CNS) neuronal surface antigens have been described in association with autoimmune encephalopathies which prominently feature psychiatric symptoms in addition to neurological symptoms. The potential role of these autoantibodies in primary psychiatric diseases such as schizophrenia or bipolar affective disorder is of increasing interest. Objectives: We aimed to review the nature of psychiatric symptoms associated with neuronal surface autoantibodies, in the context of autoimmune encephalopathies as well as primary psychiatric disorders, and to review the mechanisms of action of these autoantibodies from a psychopharmacological perspective. Results: The functional effects of the autoantibodies on their target antigens are described; their clinical expression is at least in part mediated by their effects on neuronal receptor function, primarily at the synapse, usually resulting in receptor hypofunction. The psychiatric effects of the antibodies are related to known functions of the receptor target or its complexed proteins, with reference to supportive genetic and pharmacological evidence where relevant. Evidence for a causal role of these autoantibodies in primary psychiatric disease is increasing but remains controversial; relevant methodological controversies are outlined. Non-receptor-based mechanisms of autoantibody action, including neuroinflammatory mechanisms, and therapeutic implications are discussed. Conclusions: An analysis of the autoantibodies from a psychopharmacological perspective, as endogenous, bioactive, highly specific, receptor-targeting molecules, provides a valuable opportunity to understand the neurobiological basis of associated psychiatric symptoms. Potentially, new treatment strategies will emerge from the improving understanding of antibody-antigen interaction within the CNS. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 114513710 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pollak%2C+T%2E%22">Pollak, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Beck%2C+K%2E%22">Beck, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Irani%2C+S%2E%22">Irani, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Howes%2C+O%2E%22">Howes, O.</searchLink><br /><searchLink fieldCode="AR" term="%22David%2C+A%2E%22">David, A.</searchLink><br /><searchLink fieldCode="AR" term="%22McGuire%2C+P%2E%22">McGuire, P.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. May2016, Vol. 233 Issue 9, p1605-1621. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Autoantibodies%22">Autoantibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+surface+antigens%22">Cell surface antigens</searchLink><br /><searchLink fieldCode="DE" term="%22Neuron+analysis%22">Neuron analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: Autoantibodies to central nervous system (CNS) neuronal surface antigens have been described in association with autoimmune encephalopathies which prominently feature psychiatric symptoms in addition to neurological symptoms. The potential role of these autoantibodies in primary psychiatric diseases such as schizophrenia or bipolar affective disorder is of increasing interest. Objectives: We aimed to review the nature of psychiatric symptoms associated with neuronal surface autoantibodies, in the context of autoimmune encephalopathies as well as primary psychiatric disorders, and to review the mechanisms of action of these autoantibodies from a psychopharmacological perspective. Results: The functional effects of the autoantibodies on their target antigens are described; their clinical expression is at least in part mediated by their effects on neuronal receptor function, primarily at the synapse, usually resulting in receptor hypofunction. The psychiatric effects of the antibodies are related to known functions of the receptor target or its complexed proteins, with reference to supportive genetic and pharmacological evidence where relevant. Evidence for a causal role of these autoantibodies in primary psychiatric disease is increasing but remains controversial; relevant methodological controversies are outlined. Non-receptor-based mechanisms of autoantibody action, including neuroinflammatory mechanisms, and therapeutic implications are discussed. Conclusions: An analysis of the autoantibodies from a psychopharmacological perspective, as endogenous, bioactive, highly specific, receptor-targeting molecules, provides a valuable opportunity to understand the neurobiological basis of associated psychiatric symptoms. Potentially, new treatment strategies will emerge from the improving understanding of antibody-antigen interaction within the CNS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-015-4156-y Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1605 Subjects: – SubjectFull: Autoantibodies Type: general – SubjectFull: Central nervous system Type: general – SubjectFull: Cell surface antigens Type: general – SubjectFull: Neuron analysis Type: general – SubjectFull: Mental illness Type: general Titles: – TitleFull: Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pollak, T. – PersonEntity: Name: NameFull: Beck, K. – PersonEntity: Name: NameFull: Irani, S. – PersonEntity: Name: NameFull: Howes, O. – PersonEntity: Name: NameFull: David, A. – PersonEntity: Name: NameFull: McGuire, P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 233 – Type: issue Value: 9 Titles: – TitleFull: Psychopharmacology Type: main |
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