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Striatonigral control of movement velocity in mice.

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Title: Striatonigral control of movement velocity in mice.
Authors: Bartholomew, Ryan A., Li, Haofang, Gaidis, Erin J., Stackmann, Michelle, Shoemaker, Charles T., Rossi, Mark A., Yin, Henry H., Bolam, Paul
Source: European Journal of Neuroscience. Apr2016, Vol. 43 Issue 8, p1097-1110. 14p. 1 Diagram, 12 Graphs.
Subjects: Basal ganglia, Optogenetics, Rhodopsin, Dopamine receptors, Laboratory mice, Physiology
Abstract: The basal ganglia have long been implicated in action initiation. Using three-dimensional motion capture, we quantified the effects of optogenetic stimulation of the striatonigral (direct) pathway on movement kinematics. We generated transgenic mice with channelrhodopsin-2 expression in striatal neurons that express the D1-like dopamine receptor. With optic fibres placed in the sensorimotor striatum, an area known to contain movement velocity-related single units, photo-stimulation reliably produced movements that could be precisely quantified with our motion capture programme. A single light pulse was sufficient to elicit movements with short latencies (<30 ms). Increasing stimulation frequency increased movement speed, with a highly linear relationship. These findings support the hypothesis that the sensorimotor striatum is part of a velocity controller that controls rate of change in body configurations. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Striatonigral control of movement velocity in mice.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neuroscience%22&quot;&gt;European Journal of Neuroscience&lt;/searchLink&gt;. Apr2016, Vol. 43 Issue 8, p1097-1110. 14p. 1 Diagram, 12 Graphs.
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  Data: The basal ganglia have long been implicated in action initiation. Using three-dimensional motion capture, we quantified the effects of optogenetic stimulation of the striatonigral (direct) pathway on movement kinematics. We generated transgenic mice with channelrhodopsin-2 expression in striatal neurons that express the D1-like dopamine receptor. With optic fibres placed in the sensorimotor striatum, an area known to contain movement velocity-related single units, photo-stimulation reliably produced movements that could be precisely quantified with our motion capture programme. A single light pulse was sufficient to elicit movements with short latencies (&lt;30 ms). Increasing stimulation frequency increased movement speed, with a highly linear relationship. These findings support the hypothesis that the sensorimotor striatum is part of a velocity controller that controls rate of change in body configurations. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.13187
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        Text: English
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        PageCount: 14
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        Type: general
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        Type: general
      – SubjectFull: Rhodopsin
        Type: general
      – SubjectFull: Dopamine receptors
        Type: general
      – SubjectFull: Laboratory mice
        Type: general
      – SubjectFull: Physiology
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      – TitleFull: Striatonigral control of movement velocity in mice.
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              M: 04
              Text: Apr2016
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