Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training.
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| Title: | Brain derived neurotrophic factor in multiple sclerosis: effect of 24 weeks endurance and resistance training. |
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| Authors: | Wens, I., Keytsman, C., Deckx, N., Cools, N., Dalgas, U., Eijnde, B. O. |
| Source: | European Journal of Neurology. Jun2016, Vol. 23 Issue 6, p1028-1035. 8p. |
| Subjects: | Multiple sclerosis, Neurotrophic functions, Neurophysiology, Resistance training, Physical fitness |
| Abstract: | Background and purpose Brain derived neurotrophic factor ( BDNF) is suggested to play a neuroprotective role in multiple sclerosis ( MS). However, the BDNF response to long-term exercise in MS remains unknown. Our objective was to compare resting BDNF profiles of healthy controls ( HCs) and persons with relapsing−remitting MS ( RRMS) and to investigate the impact of a 24-week exercise intervention on serum BDNF release in MS. Methods At baseline, blood BDNF levels were assessed in MS ( n = 22, mean Expanded Disability Status Scale 2.6 ± 0.2, mean age 43 ± 2 years) and HCs ( n = 19, mean age 47 ± 1 year). Next, persons with MS were randomized to an exercise intervention group ( EX, n = 15) or a sedentary control group ( SED, n = 7) completing a 24-week randomized controlled trial. In persons with MS, muscle strength, exercise tolerance and body composition were assessed, as compliance measures, at baseline and after 24 weeks. Results At baseline, the BDNF concentration of persons with RRMS was 21% lower than HCs. Following 24 weeks of intervention, changes in BDNF concentrations differed significantly between EX and SED. In particular, within EX BDNF concentrations increased 13.9% ± 8.8%, whereas it decreased 10.5% ± 4.1% within SED. Furthermore, 24 weeks of exercise induced changes in the compliance measures between EX and SED. In addition, within EX muscle strength, exercise tolerance and lean tissue mass improved, whereas these remained stable within SED. Conclusion In conclusion, BDNF concentration of persons with RRMS was lower compared to HCs and increased after 24 weeks of exercise in persons with MS, compared to the non-exercise MS control group. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background and purpose Brain derived neurotrophic factor ( BDNF) is suggested to play a neuroprotective role in multiple sclerosis ( MS). However, the BDNF response to long-term exercise in MS remains unknown. Our objective was to compare resting BDNF profiles of healthy controls ( HCs) and persons with relapsing−remitting MS ( RRMS) and to investigate the impact of a 24-week exercise intervention on serum BDNF release in MS. Methods At baseline, blood BDNF levels were assessed in MS ( n = 22, mean Expanded Disability Status Scale 2.6 ± 0.2, mean age 43 ± 2 years) and HCs ( n = 19, mean age 47 ± 1 year). Next, persons with MS were randomized to an exercise intervention group ( EX, n = 15) or a sedentary control group ( SED, n = 7) completing a 24-week randomized controlled trial. In persons with MS, muscle strength, exercise tolerance and body composition were assessed, as compliance measures, at baseline and after 24 weeks. Results At baseline, the BDNF concentration of persons with RRMS was 21% lower than HCs. Following 24 weeks of intervention, changes in BDNF concentrations differed significantly between EX and SED. In particular, within EX BDNF concentrations increased 13.9% ± 8.8%, whereas it decreased 10.5% ± 4.1% within SED. Furthermore, 24 weeks of exercise induced changes in the compliance measures between EX and SED. In addition, within EX muscle strength, exercise tolerance and lean tissue mass improved, whereas these remained stable within SED. Conclusion In conclusion, BDNF concentration of persons with RRMS was lower compared to HCs and increased after 24 weeks of exercise in persons with MS, compared to the non-exercise MS control group. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13515101 |
| DOI: | 10.1111/ene.12976 |
