The Immunological Synapse Balances T Cell ReceptorSignaling and Degradation.
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| Title: | The Immunological Synapse Balances T Cell ReceptorSignaling and Degradation. |
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| Authors: | Lee, Kyeong-Hee, Dinner, Aaron R., Tu, Chun, Campi, Gabriele, Raychaudhuri, Subhadip, Varma, Rajat, Sims, Tasha N., Burack, W. Richard, Wu, Hui, Wang, Julia, Kanagawa, Osami, Markiewicz, Mary, Allen, Paul M., Dustin, Michael L., Chakraborty, Arup K., Shaw, Andrey S. |
| Source: | Science (pre-March 2025). 11/14/2003, Vol. 302 Issue 5648, p1218-1222. 5p. 1 Diagram, 4 Graphs. |
| Subjects: | T cell receptors, Antigen presenting cells, Synapses, Cell adhesion molecules |
| Abstract: | The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. [ABSTRACT FROM AUTHOR] |
| Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.1086507 |
