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Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system.

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Title: Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system.
Authors: Marques, Sueli, Zeisel, Amit, Codeluppi, Simone, van Bruggen, David, Falcão, Ana Mendanha, Lin Xiao, Huiliang Li, Häring, Martin, Hochgerner, Hannah, Romanov, Roman A., Gyllborg, Daniel, Muñoz-Manchado, Ana B., La Manno, Gioele, Lönnerberg, Peter, Floriddia, Elisa M., Rezayee, Fatemah, Ernfors, Patrik, Arenas, Ernest, Hjerling-Leffler, Jens, Harkany, Tibor
Source: Science (pre-March 2025). 6/10/2016, Vol. 352 Issue 6291, p1326-1329. 4p.
Subjects: Oligodendroglia, RNA sequencing, Central nervous system, Neurobiology, Astrocytes
Abstract: Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS).We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra+ oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra+ population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system.
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  Data: <searchLink fieldCode="AR" term="%22Marques%2C+Sueli%22">Marques, Sueli</searchLink><br /><searchLink fieldCode="AR" term="%22Zeisel%2C+Amit%22">Zeisel, Amit</searchLink><br /><searchLink fieldCode="AR" term="%22Codeluppi%2C+Simone%22">Codeluppi, Simone</searchLink><br /><searchLink fieldCode="AR" term="%22van+Bruggen%2C+David%22">van Bruggen, David</searchLink><br /><searchLink fieldCode="AR" term="%22Falcão%2C+Ana+Mendanha%22">Falcão, Ana Mendanha</searchLink><br /><searchLink fieldCode="AR" term="%22Lin+Xiao%22">Lin Xiao</searchLink><br /><searchLink fieldCode="AR" term="%22Huiliang+Li%22">Huiliang Li</searchLink><br /><searchLink fieldCode="AR" term="%22Häring%2C+Martin%22">Häring, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22Hochgerner%2C+Hannah%22">Hochgerner, Hannah</searchLink><br /><searchLink fieldCode="AR" term="%22Romanov%2C+Roman+A%2E%22">Romanov, Roman A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gyllborg%2C+Daniel%22">Gyllborg, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Muñoz-Manchado%2C+Ana+B%2E%22">Muñoz-Manchado, Ana B.</searchLink><br /><searchLink fieldCode="AR" term="%22La+Manno%2C+Gioele%22">La Manno, Gioele</searchLink><br /><searchLink fieldCode="AR" term="%22Lönnerberg%2C+Peter%22">Lönnerberg, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Floriddia%2C+Elisa+M%2E%22">Floriddia, Elisa M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rezayee%2C+Fatemah%22">Rezayee, Fatemah</searchLink><br /><searchLink fieldCode="AR" term="%22Ernfors%2C+Patrik%22">Ernfors, Patrik</searchLink><br /><searchLink fieldCode="AR" term="%22Arenas%2C+Ernest%22">Arenas, Ernest</searchLink><br /><searchLink fieldCode="AR" term="%22Hjerling-Leffler%2C+Jens%22">Hjerling-Leffler, Jens</searchLink><br /><searchLink fieldCode="AR" term="%22Harkany%2C+Tibor%22">Harkany, Tibor</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/10/2016, Vol. 352 Issue 6291, p1326-1329. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Oligodendroglia%22">Oligodendroglia</searchLink><br /><searchLink fieldCode="DE" term="%22RNA+sequencing%22">RNA sequencing</searchLink><br /><searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Neurobiology%22">Neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Astrocytes%22">Astrocytes</searchLink>
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  Data: Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS).We performed single-cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra+ oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra+ population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=116118230
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