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Neuronal central nervous system syndromes probably mediated by autoantibodies.

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Title: Neuronal central nervous system syndromes probably mediated by autoantibodies.
Authors: Chefdeville, Aude, Honnorat, Jérôme, Hampe, Christiane S., Desestret, Virginie, Maccaferri, Gianmaria
Source: European Journal of Neuroscience. Jun2016, Vol. 43 Issue 12, p1535-1552. 18p. 2 Diagrams, 1 Chart.
Subjects: Central nervous system abnormalities, Autoantibodies, Cell surface antigens, Immunotherapy, Propionic acid, Animal models in research, Encephalitis, Glutamate receptors
Abstract: In the last few years, a rapidly growing number of autoantibodies targeting neuronal cell-surface antigens have been identified in patients presenting with neurological symptoms. Targeted antigens include ionotropic receptors such as N-methyl- d-aspartate receptor or the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, metabotropic receptors such as mGluR1 and mGluR5, and other synaptic proteins, some of them belonging to the voltage-gated potassium channel complex. Importantly, the cell-surface location of these antigens makes them vulnerable to direct antibody-mediated modulation. Some of these autoantibodies, generally targeting ionotropic channels or their partner proteins, define clinical syndromes resembling models of pharmacological or genetic disruption of the corresponding antigen, suggesting a direct pathogenic role of the associated autoantibodies. Moreover, the associated neurological symptoms are usually immunotherapy-responsive, further arguing for a pathogenic effect of the antibodies. Some studies have shown that some patients' antibodies may have structural and functional in vitro effects on the targeted antigens. Definite proof of the pathogenicity of these autoantibodies has been obtained for just a few through passive transfer experiments in animal models. In this review we present existing and converging evidence suggesting a pathogenic role of some autoantibodies directed against neuronal cell-surface antigens observed in patients with central nervous system disorders. We describe the main clinical symptoms characterizing the patients and discuss conflicting arguments regarding the pathogenicity of these antibodies. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Neuronal central nervous system syndromes probably mediated by autoantibodies.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Chefdeville%2C+Aude%22">Chefdeville, Aude</searchLink><br /><searchLink fieldCode="AR" term="%22Honnorat%2C+Jérôme%22">Honnorat, Jérôme</searchLink><br /><searchLink fieldCode="AR" term="%22Hampe%2C+Christiane+S%2E%22">Hampe, Christiane S.</searchLink><br /><searchLink fieldCode="AR" term="%22Desestret%2C+Virginie%22">Desestret, Virginie</searchLink><br /><searchLink fieldCode="AR" term="%22Maccaferri%2C+Gianmaria%22">Maccaferri, Gianmaria</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jun2016, Vol. 43 Issue 12, p1535-1552. 18p. 2 Diagrams, 1 Chart.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Central+nervous+system+abnormalities%22">Central nervous system abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Autoantibodies%22">Autoantibodies</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+surface+antigens%22">Cell surface antigens</searchLink><br /><searchLink fieldCode="DE" term="%22Immunotherapy%22">Immunotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Propionic+acid%22">Propionic acid</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink><br /><searchLink fieldCode="DE" term="%22Encephalitis%22">Encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamate+receptors%22">Glutamate receptors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In the last few years, a rapidly growing number of autoantibodies targeting neuronal cell-surface antigens have been identified in patients presenting with neurological symptoms. Targeted antigens include ionotropic receptors such as N-methyl- d-aspartate receptor or the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, metabotropic receptors such as mGluR1 and mGluR5, and other synaptic proteins, some of them belonging to the voltage-gated potassium channel complex. Importantly, the cell-surface location of these antigens makes them vulnerable to direct antibody-mediated modulation. Some of these autoantibodies, generally targeting ionotropic channels or their partner proteins, define clinical syndromes resembling models of pharmacological or genetic disruption of the corresponding antigen, suggesting a direct pathogenic role of the associated autoantibodies. Moreover, the associated neurological symptoms are usually immunotherapy-responsive, further arguing for a pathogenic effect of the antibodies. Some studies have shown that some patients' antibodies may have structural and functional in vitro effects on the targeted antigens. Definite proof of the pathogenicity of these autoantibodies has been obtained for just a few through passive transfer experiments in animal models. In this review we present existing and converging evidence suggesting a pathogenic role of some autoantibodies directed against neuronal cell-surface antigens observed in patients with central nervous system disorders. We describe the main clinical symptoms characterizing the patients and discuss conflicting arguments regarding the pathogenicity of these antibodies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=116236393
RecordInfo BibRecord:
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        Value: 10.1111/ejn.13212
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      – Code: eng
        Text: English
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        PageCount: 18
        StartPage: 1535
    Subjects:
      – SubjectFull: Central nervous system abnormalities
        Type: general
      – SubjectFull: Autoantibodies
        Type: general
      – SubjectFull: Cell surface antigens
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      – SubjectFull: Immunotherapy
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      – SubjectFull: Propionic acid
        Type: general
      – SubjectFull: Animal models in research
        Type: general
      – SubjectFull: Encephalitis
        Type: general
      – SubjectFull: Glutamate receptors
        Type: general
    Titles:
      – TitleFull: Neuronal central nervous system syndromes probably mediated by autoantibodies.
        Type: main
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            NameFull: Chefdeville, Aude
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            NameFull: Honnorat, Jérôme
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            NameFull: Hampe, Christiane S.
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            NameFull: Desestret, Virginie
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            NameFull: Maccaferri, Gianmaria
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              Text: Jun2016
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