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The association between combination antiretroviral adherence and AIDS-defining conditions at HIV diagnosis.

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Title: The association between combination antiretroviral adherence and AIDS-defining conditions at HIV diagnosis.
Authors: Abara, Winston E. (AUTHOR), Xu, Junjun (AUTHOR), Adekeye, Oluwatoyosi A. (AUTHOR), Rust, George (AUTHOR)
Source: AIDS Care. Aug2016, Vol. 28 Issue 8, p1013-1017. 5p. 2 Charts.
Subjects: Diagnosis of HIV infections, Antiretroviral agents, Comparative studies, Confidence intervals, Drugs, HIV infections, Longitudinal method, Multivariate analysis, Patient compliance, Poisson distribution, Probability theory, Regression analysis, Statistical hypothesis testing, Mathematical variables, Retrospective studies, Severity of illness index, Descriptive statistics
Geographic Terms: Georgia
Abstract: Combination antiretroviral therapy (cART) has changed the clinical course of HIV. AIDS-defining conditions (ADC) are suggestive of severe or advanced disease and are a leading cause of HIV-related hospitalizations and death among people living with HIV/AIDS (PLWHA) in the USA. Optimal adherence to cART can mitigate the impact of ADC and disease severity on the health and survivability of PLWHA. The objective of this study was to evaluate the association between ADC at HIV diagnosis and optimal adherence among PLWHA. Using data from the 2008 and 2009 Medicaid data from 29 states, we identified individuals, between 18 and 49 years, recently infected with HIV and with a cART prescription. Frequencies and descriptive statistics were conducted to characterize sample. Univariate and multivariable Poisson regression analyses were employed to evaluate the association optimal cART adherence (defined as ≥ 95% study days covered by cART) and ADC at HIV diagnosis (≥1 ADC) were assessed. Approximately 17% of respondents with ADC at HIV diagnosis reported optimal cART adherence. After adjusting for covariates, respondents with an ADC at HIV diagnosis were less likely to report optimal cART adherence (adjusted prevalence ratio (APR) = 0.64, 95% confidence intervals (CI), 0.54–0.75). Among the covariates, males (APR=1.10, 95% CI, 1.02–1.19) compared to females were significantly more likely to report optimal adherence while younger respondents, 18–29 years (APR=0.67, 95% CI, 0.57–0.77), 30–39 years (APR=0.86, 95% CI, 0.79–0.95) compared to older respondents were significantly less likely to report optimal adherence. PLWHA with ADC at HIV diagnosis are at risk of suboptimal cART adherence. Multiple adherence strategies that include healthcare providers, case managers, and peer navigators should be utilized to improve cART adherence and optimize health outcomes among PLWHA with ADC at HIV diagnosis. Targeted adherence programs and services are required to address suboptimal adherence in this population. [ABSTRACT FROM PUBLISHER]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The association between combination antiretroviral adherence and AIDS-defining conditions at HIV diagnosis.
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  Data: <searchLink fieldCode="AR" term="%22Abara%2C+Winston+E%2E%22">Abara, Winston E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Junjun%22">Xu, Junjun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Adekeye%2C+Oluwatoyosi+A%2E%22">Adekeye, Oluwatoyosi A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rust%2C+George%22">Rust, George</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Aug2016, Vol. 28 Issue 8, p1013-1017. 5p. 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+HIV+infections%22">Diagnosis of HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Antiretroviral+agents%22">Antiretroviral agents</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Poisson+distribution%22">Poisson distribution</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+hypothesis+testing%22">Statistical hypothesis testing</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+variables%22">Mathematical variables</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Georgia%22">Georgia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Combination antiretroviral therapy (cART) has changed the clinical course of HIV. AIDS-defining conditions (ADC) are suggestive of severe or advanced disease and are a leading cause of HIV-related hospitalizations and death among people living with HIV/AIDS (PLWHA) in the USA. Optimal adherence to cART can mitigate the impact of ADC and disease severity on the health and survivability of PLWHA. The objective of this study was to evaluate the association between ADC at HIV diagnosis and optimal adherence among PLWHA. Using data from the 2008 and 2009 Medicaid data from 29 states, we identified individuals, between 18 and 49 years, recently infected with HIV and with a cART prescription. Frequencies and descriptive statistics were conducted to characterize sample. Univariate and multivariable Poisson regression analyses were employed to evaluate the association optimal cART adherence (defined as ≥ 95% study days covered by cART) and ADC at HIV diagnosis (≥1 ADC) were assessed. Approximately 17% of respondents with ADC at HIV diagnosis reported optimal cART adherence. After adjusting for covariates, respondents with an ADC at HIV diagnosis were less likely to report optimal cART adherence (adjusted prevalence ratio (APR) = 0.64, 95% confidence intervals (CI), 0.54–0.75). Among the covariates, males (APR=1.10, 95% CI, 1.02–1.19) compared to females were significantly more likely to report optimal adherence while younger respondents, 18–29 years (APR=0.67, 95% CI, 0.57–0.77), 30–39 years (APR=0.86, 95% CI, 0.79–0.95) compared to older respondents were significantly less likely to report optimal adherence. PLWHA with ADC at HIV diagnosis are at risk of suboptimal cART adherence. Multiple adherence strategies that include healthcare providers, case managers, and peer navigators should be utilized to improve cART adherence and optimize health outcomes among PLWHA with ADC at HIV diagnosis. Targeted adherence programs and services are required to address suboptimal adherence in this population. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=116323435
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09540121.2016.1139044
    Languages:
      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 1013
    Subjects:
      – SubjectFull: Diagnosis of HIV infections
        Type: general
      – SubjectFull: Antiretroviral agents
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: HIV infections
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      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Poisson distribution
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      – SubjectFull: Probability theory
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      – SubjectFull: Regression analysis
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      – SubjectFull: Statistical hypothesis testing
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      – SubjectFull: Mathematical variables
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      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Georgia
        Type: general
    Titles:
      – TitleFull: The association between combination antiretroviral adherence and AIDS-defining conditions at HIV diagnosis.
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            NameFull: Xu, Junjun
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              Text: Aug2016
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