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Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression.

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Title: Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression.
Authors: Yang, Xiao‐Ru, Langevin, Lisa Marie, Jaworska, Natalia, Kirton, Adam, Lebel, R. Marc, Harris, Ashley D., Jasaui, Yamile, Wilkes, T. Christopher, Sembo, Mariko, Swansburg, Rose, MacMaster, Frank P.
Source: Psychiatry & Clinical Neurosciences. Jul2016, Vol. 70 Issue 7, p269-277. 9p. 1 Chart, 3 Graphs.
Subjects: Prefrontal cortex, Mental depression, Proton magnetic resonance spectroscopy, Choline, Phospholipids
Abstract: Aim Structural, functional, and metabolic changes in the dorsolateral prefrontal cortex ( DLPFC) are implicated in the pathogenesis of major depressive disorder ( MDD). We used proton magnetic resonance spectroscopy (1 H-MRS) to examine the metabolite choline (glycerophosphocholine plus phosphocholine), which is used as an index of membrane integrity in the left DLPFC, in adolescents and young adults with MDD who were treatment-resistant and had a positive family history compared to healthy controls. Differences in the choline resonance indicate an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids. Methods Seventeen adolescents with MDD and 11 healthy controls underwent 1 H-MRS. A short echo point-resolved spectroscopy ( echo time = 30 ms, repetition time = 2000 ms) protocol was used with a voxel (4.5cm3, 128 averages) placed within the left DLPFC. Results There were significantly increased choline ( P = 0.04) and creatine concentrations ( P = 0.005) in the left DLPFC of the MDD group compared to controls. In MDD participants, choline concentration correlated with scores on the Beck Depression Inventory ( r = 0.41, P = 0.03). Conclusion Increased left DLPFC choline and creatine levels in depressed adolescents may be biomarkers for the disorder. The increased choline levels may indicate abnormalities in neuronal membrane integrity, and the increased creatine could be reflective of altered energy demands and metabolism. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Xiao‐Ru%22">Yang, Xiao‐Ru</searchLink><br /><searchLink fieldCode="AR" term="%22Langevin%2C+Lisa+Marie%22">Langevin, Lisa Marie</searchLink><br /><searchLink fieldCode="AR" term="%22Jaworska%2C+Natalia%22">Jaworska, Natalia</searchLink><br /><searchLink fieldCode="AR" term="%22Kirton%2C+Adam%22">Kirton, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Lebel%2C+R%2E+Marc%22">Lebel, R. Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Harris%2C+Ashley+D%2E%22">Harris, Ashley D.</searchLink><br /><searchLink fieldCode="AR" term="%22Jasaui%2C+Yamile%22">Jasaui, Yamile</searchLink><br /><searchLink fieldCode="AR" term="%22Wilkes%2C+T%2E+Christopher%22">Wilkes, T. Christopher</searchLink><br /><searchLink fieldCode="AR" term="%22Sembo%2C+Mariko%22">Sembo, Mariko</searchLink><br /><searchLink fieldCode="AR" term="%22Swansburg%2C+Rose%22">Swansburg, Rose</searchLink><br /><searchLink fieldCode="AR" term="%22MacMaster%2C+Frank+P%2E%22">MacMaster, Frank P.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jul2016, Vol. 70 Issue 7, p269-277. 9p. 1 Chart, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+magnetic+resonance+spectroscopy%22">Proton magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Choline%22">Choline</searchLink><br /><searchLink fieldCode="DE" term="%22Phospholipids%22">Phospholipids</searchLink>
– Name: Abstract
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  Data: Aim Structural, functional, and metabolic changes in the dorsolateral prefrontal cortex ( DLPFC) are implicated in the pathogenesis of major depressive disorder ( MDD). We used proton magnetic resonance spectroscopy (1 H-MRS) to examine the metabolite choline (glycerophosphocholine plus phosphocholine), which is used as an index of membrane integrity in the left DLPFC, in adolescents and young adults with MDD who were treatment-resistant and had a positive family history compared to healthy controls. Differences in the choline resonance indicate an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids. Methods Seventeen adolescents with MDD and 11 healthy controls underwent 1 H-MRS. A short echo point-resolved spectroscopy ( echo time = 30 ms, repetition time = 2000 ms) protocol was used with a voxel (4.5cm3, 128 averages) placed within the left DLPFC. Results There were significantly increased choline ( P = 0.04) and creatine concentrations ( P = 0.005) in the left DLPFC of the MDD group compared to controls. In MDD participants, choline concentration correlated with scores on the Beck Depression Inventory ( r = 0.41, P = 0.03). Conclusion Increased left DLPFC choline and creatine levels in depressed adolescents may be biomarkers for the disorder. The increased choline levels may indicate abnormalities in neuronal membrane integrity, and the increased creatine could be reflective of altered energy demands and metabolism. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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