Involvement of GABA receptors in 5-HT and σ receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency.
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| Title: | Involvement of GABA receptors in 5-HT and σ receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. |
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| Authors: | Ago, Yukio, Hasebe, Shigeru, Hiramatsu, Naoki, Mori, Kazuya, Watabe, Yuji, Onaka, Yusuke, Hashimoto, Hitoshi, Takuma, Kazuhiro, Matsuda, Toshio |
| Source: | Psychopharmacology. Sep2016, Vol. 233 Issue 17, p3125-3134. 10p. 3 Diagrams, 5 Graphs. |
| Subjects: | GABA receptors, Dopaminergic mechanisms, Fluvoxamine, Adrenalectomy, Serotonin, Psychology |
| Abstract: | Rationale: We previously reported that the fluvoxamine-induced increase in prefrontal dopamine levels is enhanced by adrenalectomy/castration (which results in circulating neurosteroid deficiency), via combined activation of serotonin (5-HT) and σ receptors. However, the mechanistic details of the interaction between 5-HT and σ receptors are unknown. Objectives: Because most neurosteroids have affinity for γ-aminobutyric acid (GABA) receptors, in the present study, we examined the involvement of GABA receptors in this process. Results: Adrenalectomy/castration decreased pentobarbital-induced sleeping time in mice, suggesting that it reduced GABA receptor function. The GABA receptor antagonist picrotoxin (1 mg/kg) enhanced the fluvoxamine-induced increase in prefrontal dopamine, but not noradrenaline or serotonin, levels in mice, suggesting that picrotoxin mimicked the effect of adrenalectomy/castration. Picrotoxin also potentiated the increase in prefrontal dopamine levels mediated by co-administration of the 5-HT receptor agonist osemozotan and the σ receptor agonist (+)-SKF-10,047, while it did not affect the co-administration-induced changes in noradrenaline and serotonin levels. Conversely, the GABA receptor agonist diazepam (1 mg/kg) blocked the effect of adrenalectomy/castration on the fluvoxamine-induced increase in prefrontal dopamine levels. Co-administration of osemozotan and (+)-SKF-10,047 did not affect the expression of the neuronal activity marker c-Fos in the prefrontal cortex, ventral tegmental area, and nucleus accumbens in control mice, while it increased the c-Fos expression only in the prefrontal cortex and ventral tegmental area in picrotoxin-treated mice. Conclusions: These results suggest that the GABA receptor plays a key role in mediating the synergistic effects of 5-HT and σ receptor activation on prefrontal dopamine neurotransmission. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 117355484 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Involvement of GABA receptors in 5-HT and σ receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Ago%2C+Yukio%22">Ago, Yukio</searchLink><br /><searchLink fieldCode="AR" term="%22Hasebe%2C+Shigeru%22">Hasebe, Shigeru</searchLink><br /><searchLink fieldCode="AR" term="%22Hiramatsu%2C+Naoki%22">Hiramatsu, Naoki</searchLink><br /><searchLink fieldCode="AR" term="%22Mori%2C+Kazuya%22">Mori, Kazuya</searchLink><br /><searchLink fieldCode="AR" term="%22Watabe%2C+Yuji%22">Watabe, Yuji</searchLink><br /><searchLink fieldCode="AR" term="%22Onaka%2C+Yusuke%22">Onaka, Yusuke</searchLink><br /><searchLink fieldCode="AR" term="%22Hashimoto%2C+Hitoshi%22">Hashimoto, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Takuma%2C+Kazuhiro%22">Takuma, Kazuhiro</searchLink><br /><searchLink fieldCode="AR" term="%22Matsuda%2C+Toshio%22">Matsuda, Toshio</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Sep2016, Vol. 233 Issue 17, p3125-3134. 10p. 3 Diagrams, 5 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22GABA+receptors%22">GABA receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Dopaminergic+mechanisms%22">Dopaminergic mechanisms</searchLink><br /><searchLink fieldCode="DE" term="%22Fluvoxamine%22">Fluvoxamine</searchLink><br /><searchLink fieldCode="DE" term="%22Adrenalectomy%22">Adrenalectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: We previously reported that the fluvoxamine-induced increase in prefrontal dopamine levels is enhanced by adrenalectomy/castration (which results in circulating neurosteroid deficiency), via combined activation of serotonin (5-HT) and σ receptors. However, the mechanistic details of the interaction between 5-HT and σ receptors are unknown. Objectives: Because most neurosteroids have affinity for γ-aminobutyric acid (GABA) receptors, in the present study, we examined the involvement of GABA receptors in this process. Results: Adrenalectomy/castration decreased pentobarbital-induced sleeping time in mice, suggesting that it reduced GABA receptor function. The GABA receptor antagonist picrotoxin (1 mg/kg) enhanced the fluvoxamine-induced increase in prefrontal dopamine, but not noradrenaline or serotonin, levels in mice, suggesting that picrotoxin mimicked the effect of adrenalectomy/castration. Picrotoxin also potentiated the increase in prefrontal dopamine levels mediated by co-administration of the 5-HT receptor agonist osemozotan and the σ receptor agonist (+)-SKF-10,047, while it did not affect the co-administration-induced changes in noradrenaline and serotonin levels. Conversely, the GABA receptor agonist diazepam (1 mg/kg) blocked the effect of adrenalectomy/castration on the fluvoxamine-induced increase in prefrontal dopamine levels. Co-administration of osemozotan and (+)-SKF-10,047 did not affect the expression of the neuronal activity marker c-Fos in the prefrontal cortex, ventral tegmental area, and nucleus accumbens in control mice, while it increased the c-Fos expression only in the prefrontal cortex and ventral tegmental area in picrotoxin-treated mice. Conclusions: These results suggest that the GABA receptor plays a key role in mediating the synergistic effects of 5-HT and σ receptor activation on prefrontal dopamine neurotransmission. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-016-4353-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 3125 Subjects: – SubjectFull: GABA receptors Type: general – SubjectFull: Dopaminergic mechanisms Type: general – SubjectFull: Fluvoxamine Type: general – SubjectFull: Adrenalectomy Type: general – SubjectFull: Serotonin Type: general – SubjectFull: Psychology Type: general Titles: – TitleFull: Involvement of GABA receptors in 5-HT and σ receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Ago, Yukio – PersonEntity: Name: NameFull: Hasebe, Shigeru – PersonEntity: Name: NameFull: Hiramatsu, Naoki – PersonEntity: Name: NameFull: Mori, Kazuya – PersonEntity: Name: NameFull: Watabe, Yuji – PersonEntity: Name: NameFull: Onaka, Yusuke – PersonEntity: Name: NameFull: Hashimoto, Hitoshi – PersonEntity: Name: NameFull: Takuma, Kazuhiro – PersonEntity: Name: NameFull: Matsuda, Toshio IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 233 – Type: issue Value: 17 Titles: – TitleFull: Psychopharmacology Type: main |
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