Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment.
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| Title: | Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment. |
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| Authors: | Heuser, I., Bissette, G., Dettling, M., Schweiger, U., Gotthardt, U., Schmider, J., Lammers, C. H., Nemeroff, C. B., Holsboer, F. |
| Source: | Depression & Anxiety (1091-4269). 1998, Vol. 8 Issue 2, p71-79. 9p. 4 Charts. |
| Subjects: | Hypothalamic-pituitary-adrenal axis, Corticotropin releasing hormone, Neuropeptides, Lumbar puncture, Depression in old age |
| Abstract: | The effect of amitriptyline upon hypothalamic-pituitary-adrenal [HPA]-system-regulating neuropeptides (corticotropin-releasing hormone [CRH], vasopressin, somatostatin) was studied in a group of depressed elderly patients and controls. A first lumbar puncture was performed in 37 depressed in-patients. This was followed by a 6-week medication phase with amitriptyline. Upon its completion a second cerebrospinal fluid (CSF) sample was obtained in 18 of these 37 patients. In 25 healthy controls a first lumbar puncture was done; eleven of these individuals agreed to take 75 mg/d amitriptyline for 6 weeks and to participate in the follow-up CSF study. Within the group of depressed patients amitriptyline led to a significant decrease of CSF CRH in treatment responders only (F[sub 1,16] = 5.2; P < 0.02). Also, in normal controls CSF CRH concentration tended to decrease with amitriptyline treatment (t -test; P < 0.09). No effects of amitriptyline upon vasopressin or somatostatin were observed. In normal controls (r = 0.4; P < 0.02) and in patients (r = 0.4; P < 0.03) age correlated positively with baseline CSF somatostatin. A trend for CSF CRH to increase with aging was found only in controls (r = 0.3; P < 0.09); patients did not show a significant association here. Finally, CSF neuropeptide concentration at baseline did not differ between the group of depressed patients and healthy controls. Our study corroborates the evolving concept that antidepressants effect various components of the HPA system with the net result of a reduction in its activity. In addition, we found CSF CRH and CSF somatostatin concentrations to be better reflections of age than of depression and, finally, that during aging and during depression the HPA system changes in similar directions. Depression and Anxiety 8:71–79, 1998. © 1998 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11772795 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Heuser%2C+I%2E%22">Heuser, I.</searchLink><br /><searchLink fieldCode="AR" term="%22Bissette%2C+G%2E%22">Bissette, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Dettling%2C+M%2E%22">Dettling, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Schweiger%2C+U%2E%22">Schweiger, U.</searchLink><br /><searchLink fieldCode="AR" term="%22Gotthardt%2C+U%2E%22">Gotthardt, U.</searchLink><br /><searchLink fieldCode="AR" term="%22Schmider%2C+J%2E%22">Schmider, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lammers%2C+C%2E+H%2E%22">Lammers, C. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Nemeroff%2C+C%2E+B%2E%22">Nemeroff, C. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Holsboer%2C+F%2E%22">Holsboer, F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 1998, Vol. 8 Issue 2, p71-79. 9p. 4 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hypothalamic-pituitary-adrenal+axis%22">Hypothalamic-pituitary-adrenal axis</searchLink><br /><searchLink fieldCode="DE" term="%22Corticotropin+releasing+hormone%22">Corticotropin releasing hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropeptides%22">Neuropeptides</searchLink><br /><searchLink fieldCode="DE" term="%22Lumbar+puncture%22">Lumbar puncture</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+in+old+age%22">Depression in old age</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The effect of amitriptyline upon hypothalamic-pituitary-adrenal [HPA]-system-regulating neuropeptides (corticotropin-releasing hormone [CRH], vasopressin, somatostatin) was studied in a group of depressed elderly patients and controls. A first lumbar puncture was performed in 37 depressed in-patients. This was followed by a 6-week medication phase with amitriptyline. Upon its completion a second cerebrospinal fluid (CSF) sample was obtained in 18 of these 37 patients. In 25 healthy controls a first lumbar puncture was done; eleven of these individuals agreed to take 75 mg/d amitriptyline for 6 weeks and to participate in the follow-up CSF study. Within the group of depressed patients amitriptyline led to a significant decrease of CSF CRH in treatment responders only (F[sub 1,16] = 5.2; P < 0.02). Also, in normal controls CSF CRH concentration tended to decrease with amitriptyline treatment (t -test; P < 0.09). No effects of amitriptyline upon vasopressin or somatostatin were observed. In normal controls (r = 0.4; P < 0.02) and in patients (r = 0.4; P < 0.03) age correlated positively with baseline CSF somatostatin. A trend for CSF CRH to increase with aging was found only in controls (r = 0.3; P < 0.09); patients did not show a significant association here. Finally, CSF neuropeptide concentration at baseline did not differ between the group of depressed patients and healthy controls. Our study corroborates the evolving concept that antidepressants effect various components of the HPA system with the net result of a reduction in its activity. In addition, we found CSF CRH and CSF somatostatin concentrations to be better reflections of age than of depression and, finally, that during aging and during depression the HPA system changes in similar directions. Depression and Anxiety 8:71–79, 1998. © 1998 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/(SICI)1520-6394(1998)8:2<71::AID-DA5>3.0.CO;2-N Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 71 Subjects: – SubjectFull: Hypothalamic-pituitary-adrenal axis Type: general – SubjectFull: Corticotropin releasing hormone Type: general – SubjectFull: Neuropeptides Type: general – SubjectFull: Lumbar puncture Type: general – SubjectFull: Depression in old age Type: general Titles: – TitleFull: Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Heuser, I. – PersonEntity: Name: NameFull: Bissette, G. – PersonEntity: Name: NameFull: Dettling, M. – PersonEntity: Name: NameFull: Schweiger, U. – PersonEntity: Name: NameFull: Gotthardt, U. – PersonEntity: Name: NameFull: Schmider, J. – PersonEntity: Name: NameFull: Lammers, C. H. – PersonEntity: Name: NameFull: Nemeroff, C. B. – PersonEntity: Name: NameFull: Holsboer, F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 10914269 Numbering: – Type: volume Value: 8 – Type: issue Value: 2 Titles: – TitleFull: Depression & Anxiety (1091-4269) Type: main |
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