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Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly.

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Title: Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly.
Authors: Bump, Gregory M., Mulsant, Benoit H., Pollock, Bruce G., Mazumdar, Sati, Begley, Amy E., Dew, Mary Amanda, Reynolds III, Charles F., Bump, G M (AUTHOR), Mulsant, B H (AUTHOR), Pollock, B G (AUTHOR), Mazumdar, S (AUTHOR), Begley, A E (AUTHOR), Dew, M A (AUTHOR), Reynolds, C F 3rd (AUTHOR)
Source: Depression & Anxiety (1091-4269). 2001, Vol. 13 Issue 1, p38-44. 7p. 1 Chart, 4 Graphs.
Subjects: Depression in old age, Geriatric psychiatry, Mental depression, Antidepressants, Serotonin uptake inhibitors, Diagnosis of mental depression, Geriatric psychology, Clinical trials, Comparative studies, Longitudinal method, Research methodology, Medical cooperation, Psychological tests, Research, Time, Disease relapse, Evaluation research, Randomized controlled trials, Paroxetine, Blind experiment, Severity of illness index, Adrenergic uptake inhibitors, Nortriptyline (Drug)
Abstract: Elderly depressed patients are vulnerable to recurrence of depression and benefit from long-term antidepressant therapy. Physicians increasingly use selective serotonin re-uptake inhibitors (SSRIs) as maintenance therapy, although in the absence of data showing that SSRIs are as efficacious as tricyclic antidepressants (TCAs) in the prevention of depression relapse and recurrence. Our objective was to evaluate, in an open trial, the efficacy of paroxetine versus nortriptyline for preventing recurrence of depression in the elderly. Elderly patients with major depression were randomly assigned in a double-blinded fashion to receive either paroxetine or nortriptyline for the acute treatment of depression. Patients who did not respond or tolerate their assigned medications were crossed over openly to the comparator agent. Patients whose depression remitted continued antidepressant medication (paroxetine n = 38; nortriptyline n = 21) during an open 18-month follow-up study. We examined the rates of and times to relapse and to termination of treatment for any reason. Paroxetine (PX) and nortriptyline (NT) patients had similar rates of relapse (16% vs. 10%, respectively) and time to relapse (60.3 weeks vs. 58.8 weeks, respectively) over 18 months. A lower burden of residual depressive symptoms and side effects during continuation and maintenance treatment was evident in nortriptyline-treated patients. Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly.
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  Data: <searchLink fieldCode="AR" term="%22Bump%2C+Gregory+M%2E%22">Bump, Gregory M.</searchLink><br /><searchLink fieldCode="AR" term="%22Mulsant%2C+Benoit+H%2E%22">Mulsant, Benoit H.</searchLink><br /><searchLink fieldCode="AR" term="%22Pollock%2C+Bruce+G%2E%22">Pollock, Bruce G.</searchLink><br /><searchLink fieldCode="AR" term="%22Mazumdar%2C+Sati%22">Mazumdar, Sati</searchLink><br /><searchLink fieldCode="AR" term="%22Begley%2C+Amy+E%2E%22">Begley, Amy E.</searchLink><br /><searchLink fieldCode="AR" term="%22Dew%2C+Mary+Amanda%22">Dew, Mary Amanda</searchLink><br /><searchLink fieldCode="AR" term="%22Reynolds+III%2C+Charles+F%2E%22">Reynolds III, Charles F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bump%2C+G+M%22">Bump, G M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mulsant%2C+B+H%22">Mulsant, B H</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pollock%2C+B+G%22">Pollock, B G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mazumdar%2C+S%22">Mazumdar, S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Begley%2C+A+E%22">Begley, A E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dew%2C+M+A%22">Dew, M A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reynolds%2C+C+F+3rd%22">Reynolds, C F 3rd</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 2001, Vol. 13 Issue 1, p38-44. 7p. 1 Chart, 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Depression+in+old+age%22">Depression in old age</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatric+psychiatry%22">Geriatric psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis+of+mental+depression%22">Diagnosis of mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatric+psychology%22">Geriatric psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+tests%22">Psychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Time%22">Time</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse%22">Disease relapse</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Paroxetine%22">Paroxetine</searchLink><br /><searchLink fieldCode="DE" term="%22Blind+experiment%22">Blind experiment</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink><br /><searchLink fieldCode="DE" term="%22Adrenergic+uptake+inhibitors%22">Adrenergic uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Nortriptyline+%28Drug%29%22">Nortriptyline (Drug)</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Elderly depressed patients are vulnerable to recurrence of depression and benefit from long-term antidepressant therapy. Physicians increasingly use selective serotonin re-uptake inhibitors (SSRIs) as maintenance therapy, although in the absence of data showing that SSRIs are as efficacious as tricyclic antidepressants (TCAs) in the prevention of depression relapse and recurrence. Our objective was to evaluate, in an open trial, the efficacy of paroxetine versus nortriptyline for preventing recurrence of depression in the elderly. Elderly patients with major depression were randomly assigned in a double-blinded fashion to receive either paroxetine or nortriptyline for the acute treatment of depression. Patients who did not respond or tolerate their assigned medications were crossed over openly to the comparator agent. Patients whose depression remitted continued antidepressant medication (paroxetine n = 38; nortriptyline n = 21) during an open 18-month follow-up study. We examined the rates of and times to relapse and to termination of treatment for any reason. Paroxetine (PX) and nortriptyline (NT) patients had similar rates of relapse (16% vs. 10%, respectively) and time to relapse (60.3 weeks vs. 58.8 weeks, respectively) over 18 months. A lower burden of residual depressive symptoms and side effects during continuation and maintenance treatment was evident in nortriptyline-treated patients. Paroxetine and nortriptyline demonstrated similar efficacy in relapse and recurrence prevention in elderly depressed patients over an 18-month period. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11773016
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      – Type: doi
        Value: 10.1002/1520-6394(2001)13:1<38::AID-DA6>3.0.CO;2-7
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      – Code: eng
        Text: English
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        StartPage: 38
    Subjects:
      – SubjectFull: Depression in old age
        Type: general
      – SubjectFull: Geriatric psychiatry
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Serotonin uptake inhibitors
        Type: general
      – SubjectFull: Diagnosis of mental depression
        Type: general
      – SubjectFull: Geriatric psychology
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Psychological tests
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Time
        Type: general
      – SubjectFull: Disease relapse
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Paroxetine
        Type: general
      – SubjectFull: Blind experiment
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Adrenergic uptake inhibitors
        Type: general
      – SubjectFull: Nortriptyline (Drug)
        Type: general
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      – TitleFull: Paroxetine versus nortriptyline in the continuation and maintenance treatment of depression in the elderly.
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