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Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters.

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Title: Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters.
Authors: Kohlert, Jess G., Meisel, Robert L.
Source: Aggressive Behavior. 2001, Vol. 27 Issue 5, p372-381. 10p. 4 Graphs.
Subjects: Animal social behavior, Progesterone, Golden hamster, Animal psychology, GABA receptors, Progestational hormones
Abstract: The sequence of estradiol and progesterone is known to inhibit the expression of aggression in female hamsters. Despite the key importance of progesterone in the inhibition of aggression, little is known of the mechanisms through which progesterone may exert this effect. Three experiments were performed to assess the degree to which metabolites of progesterone can affect aggression in female Syrian hamsters. Systemic estradiol treatment followed by injections of either progesterone (300 μg IP) or 4-pregnen-21-ol-3,20-dione (DOC, 300 μg IP) reliably inhibited aggression. Systemic injection (75, 150, or 300 μg IP) of either 5α-pregnan-3α,21-diol-20-one (THDOC) or 5α-pregnan-3α-ol-20-one (3α,5α-THP) did not affect aggression. Intracerebroventricular infusion of 3α,5α-THP following systemic estradiol treatment also did not affect aggression. In a third experiment, female hamsters were given systemic treatments with estradiol and progesterone that were subthreshold with respect to inhibition of aggression. In these females, intracerebroventricular infusion of THDOC inhibited aggression. These results indicate that metabolites of progesterone can inhibit aggression, most notably in synergy with progesterone itself. Aggr. Behav. 27:372–381, 2001. © 2001 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
Copyright of Aggressive Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters.
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  Data: <searchLink fieldCode="AR" term="%22Kohlert%2C+Jess+G%2E%22">Kohlert, Jess G.</searchLink><br /><searchLink fieldCode="AR" term="%22Meisel%2C+Robert+L%2E%22">Meisel, Robert L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Aggressive+Behavior%22">Aggressive Behavior</searchLink>. 2001, Vol. 27 Issue 5, p372-381. 10p. 4 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Animal+social+behavior%22">Animal social behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Progesterone%22">Progesterone</searchLink><br /><searchLink fieldCode="DE" term="%22Golden+hamster%22">Golden hamster</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+psychology%22">Animal psychology</searchLink><br /><searchLink fieldCode="DE" term="%22GABA+receptors%22">GABA receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Progestational+hormones%22">Progestational hormones</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: The sequence of estradiol and progesterone is known to inhibit the expression of aggression in female hamsters. Despite the key importance of progesterone in the inhibition of aggression, little is known of the mechanisms through which progesterone may exert this effect. Three experiments were performed to assess the degree to which metabolites of progesterone can affect aggression in female Syrian hamsters. Systemic estradiol treatment followed by injections of either progesterone (300 μg IP) or 4-pregnen-21-ol-3,20-dione (DOC, 300 μg IP) reliably inhibited aggression. Systemic injection (75, 150, or 300 μg IP) of either 5α-pregnan-3α,21-diol-20-one (THDOC) or 5α-pregnan-3α-ol-20-one (3α,5α-THP) did not affect aggression. Intracerebroventricular infusion of 3α,5α-THP following systemic estradiol treatment also did not affect aggression. In a third experiment, female hamsters were given systemic treatments with estradiol and progesterone that were subthreshold with respect to inhibition of aggression. In these females, intracerebroventricular infusion of THDOC inhibited aggression. These results indicate that metabolites of progesterone can inhibit aggression, most notably in synergy with progesterone itself. Aggr. Behav. 27:372–381, 2001. © 2001 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Aggressive Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/ab.1022
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      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 372
    Subjects:
      – SubjectFull: Animal social behavior
        Type: general
      – SubjectFull: Progesterone
        Type: general
      – SubjectFull: Golden hamster
        Type: general
      – SubjectFull: Animal psychology
        Type: general
      – SubjectFull: GABA receptors
        Type: general
      – SubjectFull: Progestational hormones
        Type: general
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      – TitleFull: Inhibition of aggression by progesterone and its metabolites in female Syrian hamsters.
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            NameFull: Meisel, Robert L.
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              M: 09
              Text: 2001
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              Y: 2001
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              Value: 27
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              Value: 5
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            – TitleFull: Aggressive Behavior
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