Neural progenitor cells and developmental disorders.
Saved in:
| Title: | Neural progenitor cells and developmental disorders. |
|---|---|
| Authors: | Mehler, Mark F., Kessler, John A. |
| Source: | Mental Retardation & Developmental Disabilities Research Reviews. 1998, Vol. 4 Issue 3, p143-149. 7p. |
| Subjects: | Developmental neurobiology, Oligodendroglia, Neuroplasticity, Neural development, Neural stem cells, Astrocytes |
| Abstract: | Neural stem/multipotent progenitor cells are present within periventricular generative zones along the entire neuraxis throughout neural development and during adult life. These cells give rise to all of the major cellular elements of the brain, including neurons, oligodendroglia, and astrocytes. Recent studies suggest that cells with a similarly broad lineage potential are also present in postmigratory domains of the postnatal and the adult cerebral cortex. Neural stem cells are defined by a number of properties, including their ability to undergo constitutive proliferation, to maintain themselves (self-renew), to generate large numbers of progeny through transient amplification of intermediate progenitor pools, and to generate new cells in response to injury or disease. These primordial neural cells undergo progressive lineage restriction and commitment to specific neuronal and glial phenotypes in response to cascades of cytokines and the induction of positive and negative transcriptional regulators. These cytokines regulate a range of interrelated cellular processes, including activation, proliferation, viability, lineage commitment, and progressive stages of neuronal and glial lineage maturation. The detailed definition of developmental pathways responsible for neurogenesis and gliogenesis in the mammalian brain will further our understanding of the molecular and cellular basis of mental retardation and other pervasive neurologic disorders of childhood. Further, these cumulative studies suggest that a broad array of neural regenerative strategies, including gene and progenitor cell replacement and activation of endogenous cellular populations, may allow structural and functional reconstitution of neural circuits damaged as a consequence of a spectrum of neurodevelopmental disorders. MRDD Research Reviews 1998; 4:143–149. © 1998 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11781968 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Neural progenitor cells and developmental disorders. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mehler%2C+Mark+F%2E%22">Mehler, Mark F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kessler%2C+John+A%2E%22">Kessler, John A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Mental+Retardation+%26+Developmental+Disabilities+Research+Reviews%22">Mental Retardation & Developmental Disabilities Research Reviews</searchLink>. 1998, Vol. 4 Issue 3, p143-149. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Developmental+neurobiology%22">Developmental neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Oligodendroglia%22">Oligodendroglia</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+stem+cells%22">Neural stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Astrocytes%22">Astrocytes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Neural stem/multipotent progenitor cells are present within periventricular generative zones along the entire neuraxis throughout neural development and during adult life. These cells give rise to all of the major cellular elements of the brain, including neurons, oligodendroglia, and astrocytes. Recent studies suggest that cells with a similarly broad lineage potential are also present in postmigratory domains of the postnatal and the adult cerebral cortex. Neural stem cells are defined by a number of properties, including their ability to undergo constitutive proliferation, to maintain themselves (self-renew), to generate large numbers of progeny through transient amplification of intermediate progenitor pools, and to generate new cells in response to injury or disease. These primordial neural cells undergo progressive lineage restriction and commitment to specific neuronal and glial phenotypes in response to cascades of cytokines and the induction of positive and negative transcriptional regulators. These cytokines regulate a range of interrelated cellular processes, including activation, proliferation, viability, lineage commitment, and progressive stages of neuronal and glial lineage maturation. The detailed definition of developmental pathways responsible for neurogenesis and gliogenesis in the mammalian brain will further our understanding of the molecular and cellular basis of mental retardation and other pervasive neurologic disorders of childhood. Further, these cumulative studies suggest that a broad array of neural regenerative strategies, including gene and progenitor cell replacement and activation of endogenous cellular populations, may allow structural and functional reconstitution of neural circuits damaged as a consequence of a spectrum of neurodevelopmental disorders. MRDD Research Reviews 1998; 4:143–149. © 1998 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11781968 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/(SICI)1098-2779(1998)4:3<143::AID-MRDD1>3.0.CO;2-P Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 143 Subjects: – SubjectFull: Developmental neurobiology Type: general – SubjectFull: Oligodendroglia Type: general – SubjectFull: Neuroplasticity Type: general – SubjectFull: Neural development Type: general – SubjectFull: Neural stem cells Type: general – SubjectFull: Astrocytes Type: general Titles: – TitleFull: Neural progenitor cells and developmental disorders. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mehler, Mark F. – PersonEntity: Name: NameFull: Kessler, John A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 10804013 Numbering: – Type: volume Value: 4 – Type: issue Value: 3 Titles: – TitleFull: Mental Retardation & Developmental Disabilities Research Reviews Type: main |
| ResultId | 1 |
