Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models.
Saved in:
| Title: | Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models. |
|---|---|
| Authors: | Hornig, Mady, Lipkin, W. Ian |
| Source: | Mental Retardation & Developmental Disabilities Research Reviews. 2001, Vol. 7 Issue 3, p200-210. 11p. |
| Subjects: | Human abnormalities, Neurodevelopmental treatment, Heredity, Intellectual disabilities, Genetic disorders, Epidemiology |
| Abstract: | Both genetic and environmental factors contribute to the pathogenesis of a wide variety of neurodevelopmental disorders, including autism, mental retardation, and schizophrenia. Some heritable disorders approach 100% penetrance; nonetheless, even in these disorders, subtle aspects of clinical disease expression may be influenced by the environment. In other disorders with genetic influences, exogenous factors, and the timepoint(s) during nervous system development at which they are introduced, modulate expression of disease. Elucidation of the mechanisms guiding this intricate interplay between host response genes, environmental agents, and the neurodevelopmental context within which these interactions occur, is necessary to understand the continuum of clinical outcomes. This chapter will review the evidence that infectious and immune factors may contribute to the pathogenesis of neurodevelopmental disorders, describe an animal model of neurodevelopmental disorders based upon viral infection, identify processes by which neural circuitry may be compromised, and outline areas for future research. MRDD Research Reviews 2001;7:200–210. © 2001 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
| Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 11782089 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hornig%2C+Mady%22">Hornig, Mady</searchLink><br /><searchLink fieldCode="AR" term="%22Lipkin%2C+W%2E+Ian%22">Lipkin, W. Ian</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Mental+Retardation+%26+Developmental+Disabilities+Research+Reviews%22">Mental Retardation & Developmental Disabilities Research Reviews</searchLink>. 2001, Vol. 7 Issue 3, p200-210. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Human+abnormalities%22">Human abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Neurodevelopmental+treatment%22">Neurodevelopmental treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Heredity%22">Heredity</searchLink><br /><searchLink fieldCode="DE" term="%22Intellectual+disabilities%22">Intellectual disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Epidemiology%22">Epidemiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Both genetic and environmental factors contribute to the pathogenesis of a wide variety of neurodevelopmental disorders, including autism, mental retardation, and schizophrenia. Some heritable disorders approach 100% penetrance; nonetheless, even in these disorders, subtle aspects of clinical disease expression may be influenced by the environment. In other disorders with genetic influences, exogenous factors, and the timepoint(s) during nervous system development at which they are introduced, modulate expression of disease. Elucidation of the mechanisms guiding this intricate interplay between host response genes, environmental agents, and the neurodevelopmental context within which these interactions occur, is necessary to understand the continuum of clinical outcomes. This chapter will review the evidence that infectious and immune factors may contribute to the pathogenesis of neurodevelopmental disorders, describe an animal model of neurodevelopmental disorders based upon viral infection, identify processes by which neural circuitry may be compromised, and outline areas for future research. MRDD Research Reviews 2001;7:200–210. © 2001 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Mental Retardation & Developmental Disabilities Research Reviews is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11782089 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrdd.1028 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 200 Subjects: – SubjectFull: Human abnormalities Type: general – SubjectFull: Neurodevelopmental treatment Type: general – SubjectFull: Heredity Type: general – SubjectFull: Intellectual disabilities Type: general – SubjectFull: Genetic disorders Type: general – SubjectFull: Epidemiology Type: general Titles: – TitleFull: Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: Epidemiology, hypotheses, and animal models. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hornig, Mady – PersonEntity: Name: NameFull: Lipkin, W. Ian IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: 2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 10804013 Numbering: – Type: volume Value: 7 – Type: issue Value: 3 Titles: – TitleFull: Mental Retardation & Developmental Disabilities Research Reviews Type: main |
| ResultId | 1 |
