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METHODOLOGICAL ISSUES IN CHARACTERIZING TREATMENT RESPONSE IN DEMENTED PATIENTS WITH BEHAVIORAL DISTURBANCES.

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Title: METHODOLOGICAL ISSUES IN CHARACTERIZING TREATMENT RESPONSE IN DEMENTED PATIENTS WITH BEHAVIORAL DISTURBANCES.
Authors: Mulsant, Benoit H., Mazumdar, Sati, Pollock, Bruce G., Sweet, Roberta A., Rosen, Jules, Kim Lo, Jules
Source: International Journal of Geriatric Psychiatry. May1997, Vol. 12 Issue 5, p537-547. 11p. 4 Charts, 2 Graphs.
Subjects: Dementia, Behavior Disorders Identification Scale, Psychiatric diagnosis, Older people, Antipsychotic agents
Abstract: Despite the proliferation of instruments developed to rate behavioral disturbances associated with dementia, systematic studies of how ratings on these instruments should be analyzed to measure change in disruptive behaviors or distressing symptoms (ie treatment response) are noticeably absent. Using one of these scales, we compared three methods to characterize treatment response in 52 elderly demented inpatients who participated in a standardized neuroleptic trial. While all three analyses identified a statistically significant improvement, they conveyed differently the clinical improvement experienced by the patients. Categorical outcomes communicated the clinical meaning of improvement better than changes in total score; changes in factor scores best revealed the differential impact of treatment on specific behavioral and symptomatic domains. Given the heterogeneity of the problematic behaviors and symptoms exhibited by demented patients included in treatment trials, regardless of the intervention being tested or of the instrument being used to rate behaviors, a focused approach to characterizing treatment response is needed. © 1997 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: METHODOLOGICAL ISSUES IN CHARACTERIZING TREATMENT RESPONSE IN DEMENTED PATIENTS WITH BEHAVIORAL DISTURBANCES.
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  Data: <searchLink fieldCode="AR" term="%22Mulsant%2C+Benoit+H%2E%22">Mulsant, Benoit H.</searchLink><br /><searchLink fieldCode="AR" term="%22Mazumdar%2C+Sati%22">Mazumdar, Sati</searchLink><br /><searchLink fieldCode="AR" term="%22Pollock%2C+Bruce+G%2E%22">Pollock, Bruce G.</searchLink><br /><searchLink fieldCode="AR" term="%22Sweet%2C+Roberta+A%2E%22">Sweet, Roberta A.</searchLink><br /><searchLink fieldCode="AR" term="%22Rosen%2C+Jules%22">Rosen, Jules</searchLink><br /><searchLink fieldCode="AR" term="%22Kim+Lo%2C+Jules%22">Kim Lo, Jules</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. May1997, Vol. 12 Issue 5, p537-547. 11p. 4 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Dementia%22">Dementia</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+Disorders+Identification+Scale%22">Behavior Disorders Identification Scale</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+diagnosis%22">Psychiatric diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Older+people%22">Older people</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Despite the proliferation of instruments developed to rate behavioral disturbances associated with dementia, systematic studies of how ratings on these instruments should be analyzed to measure change in disruptive behaviors or distressing symptoms (ie treatment response) are noticeably absent. Using one of these scales, we compared three methods to characterize treatment response in 52 elderly demented inpatients who participated in a standardized neuroleptic trial. While all three analyses identified a statistically significant improvement, they conveyed differently the clinical improvement experienced by the patients. Categorical outcomes communicated the clinical meaning of improvement better than changes in total score; changes in factor scores best revealed the differential impact of treatment on specific behavioral and symptomatic domains. Given the heterogeneity of the problematic behaviors and symptoms exhibited by demented patients included in treatment trials, regardless of the intervention being tested or of the instrument being used to rate behaviors, a focused approach to characterizing treatment response is needed. © 1997 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=11820831
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        Value: 10.1002/(SICI)1099-1166(199705)12:5<537::AID-GPS542>3.0.CO;2-Z
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Behavior Disorders Identification Scale
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      – SubjectFull: Psychiatric diagnosis
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      – SubjectFull: Older people
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            NameFull: Sweet, Roberta A.
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              Text: May1997
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              Y: 1997
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