View in EDS PDF Full Text

Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers.

Saved in:
Bibliographic Details
Title: Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers.
Authors: Alexander, Kimberly, Cooper, Bruce, Paul, Steven, Yates, Patsy, Aouizerat, Bradley, Miaskowski, Christine, Alexander, Kimberly E (AUTHOR), Cooper, Bruce A (AUTHOR), Paul, Steven M (AUTHOR), Aouizerat, Bradley E (AUTHOR)
Source: Quality of Life Research. Nov2016, Vol. 25 Issue 11, p2853-2868. 16p.
Subjects: Phenotypic plasticity, Quality of life, Cancer patients, NF-kappa B, Cytokines, Mental health, Tumors & psychology, Psychology of caregivers, Genetic polymorphisms, Longitudinal method, Patient psychology, Research funding, Phenotypes
Abstract: Purpose: Not all oncology patients and their family caregivers (FCs) experience the same quality of life (QOL). The purposes of this study were to identify latent classes of oncology patients (n = 168) and their FCs (n = 85) with distinct physical, psychological, social, and spiritual well-being trajectories from prior to through 4 months after the completion of radiation therapy and to evaluate for demographic, clinical, and genetic characteristics that distinguished between these latent classes.Methods: Using growth mixture modeling, two latent classes were found for three (i.e., physical, psychological, and social well-being) of the four QOL domains evaluated.Results: Across these three domains, the largest percentage of participants reported relatively high well-being scores across the 6 months of the study. Across these three QOL domains, patients and FCs who were younger, female, belonged to an ethnic minority group, had children at home, had multiple comorbid conditions, or had a lower functional status, were more likely to be classified in the lower QOL class. The social well-being domain was the only domain that had a polymorphism in nuclear factor kappa beta 2 (NFKB2) associated with latent class membership. Carrying one or two doses of the rare allele for rs7897947 was associated with a 54 % decrease in the odds of belonging to the lower social well-being class [OR (95 % CI) = .46 (.21, .99), p = .049].Conclusions: These findings suggest that a number of phenotypic and molecular characteristics contribute to differences in QOL in oncology patients and their FCs. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 118833262
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Alexander%2C+Kimberly%22">Alexander, Kimberly</searchLink><br /><searchLink fieldCode="AR" term="%22Cooper%2C+Bruce%22">Cooper, Bruce</searchLink><br /><searchLink fieldCode="AR" term="%22Paul%2C+Steven%22">Paul, Steven</searchLink><br /><searchLink fieldCode="AR" term="%22Yates%2C+Patsy%22">Yates, Patsy</searchLink><br /><searchLink fieldCode="AR" term="%22Aouizerat%2C+Bradley%22">Aouizerat, Bradley</searchLink><br /><searchLink fieldCode="AR" term="%22Miaskowski%2C+Christine%22">Miaskowski, Christine</searchLink><br /><searchLink fieldCode="AR" term="%22Alexander%2C+Kimberly+E%22">Alexander, Kimberly E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cooper%2C+Bruce+A%22">Cooper, Bruce A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paul%2C+Steven+M%22">Paul, Steven M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aouizerat%2C+Bradley+E%22">Aouizerat, Bradley E</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Nov2016, Vol. 25 Issue 11, p2853-2868. 16p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Phenotypic+plasticity%22">Phenotypic plasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+patients%22">Cancer patients</searchLink><br /><searchLink fieldCode="DE" term="%22NF-kappa+B%22">NF-kappa B</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors+%26+psychology%22">Tumors & psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology+of+caregivers%22">Psychology of caregivers</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+psychology%22">Patient psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Purpose: </bold>Not all oncology patients and their family caregivers (FCs) experience the same quality of life (QOL). The purposes of this study were to identify latent classes of oncology patients (n = 168) and their FCs (n = 85) with distinct physical, psychological, social, and spiritual well-being trajectories from prior to through 4 months after the completion of radiation therapy and to evaluate for demographic, clinical, and genetic characteristics that distinguished between these latent classes.<bold>Methods: </bold>Using growth mixture modeling, two latent classes were found for three (i.e., physical, psychological, and social well-being) of the four QOL domains evaluated.<bold>Results: </bold>Across these three domains, the largest percentage of participants reported relatively high well-being scores across the 6 months of the study. Across these three QOL domains, patients and FCs who were younger, female, belonged to an ethnic minority group, had children at home, had multiple comorbid conditions, or had a lower functional status, were more likely to be classified in the lower QOL class. The social well-being domain was the only domain that had a polymorphism in nuclear factor kappa beta 2 (NFKB2) associated with latent class membership. Carrying one or two doses of the rare allele for rs7897947 was associated with a 54 % decrease in the odds of belonging to the lower social well-being class [OR (95 % CI) = .46 (.21, .99), p = .049].<bold>Conclusions: </bold>These findings suggest that a number of phenotypic and molecular characteristics contribute to differences in QOL in oncology patients and their FCs. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=118833262
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s11136-016-1310-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 16
        StartPage: 2853
    Subjects:
      – SubjectFull: Phenotypic plasticity
        Type: general
      – SubjectFull: Quality of life
        Type: general
      – SubjectFull: Cancer patients
        Type: general
      – SubjectFull: NF-kappa B
        Type: general
      – SubjectFull: Cytokines
        Type: general
      – SubjectFull: Mental health
        Type: general
      – SubjectFull: Tumors & psychology
        Type: general
      – SubjectFull: Psychology of caregivers
        Type: general
      – SubjectFull: Genetic polymorphisms
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Patient psychology
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Phenotypes
        Type: general
    Titles:
      – TitleFull: Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Alexander, Kimberly
      – PersonEntity:
          Name:
            NameFull: Cooper, Bruce
      – PersonEntity:
          Name:
            NameFull: Paul, Steven
      – PersonEntity:
          Name:
            NameFull: Yates, Patsy
      – PersonEntity:
          Name:
            NameFull: Aouizerat, Bradley
      – PersonEntity:
          Name:
            NameFull: Miaskowski, Christine
      – PersonEntity:
          Name:
            NameFull: Alexander, Kimberly E
      – PersonEntity:
          Name:
            NameFull: Cooper, Bruce A
      – PersonEntity:
          Name:
            NameFull: Paul, Steven M
      – PersonEntity:
          Name:
            NameFull: Aouizerat, Bradley E
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2016
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-print
              Value: 09629343
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Quality of Life Research
              Type: main
ResultId 1