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Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria.

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Title: Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria.
Authors: Gray, Todd A., Clark, Ryan R., Boucher, Nathalie, Lapierre, Pascal, Smith, Carol, Derbyshire, Keith M.
Source: Science (pre-March 2025). 10/21/2016, Vol. 354 Issue 6310, p347-350. 4p. 1 Diagram, 2 Graphs.
Subjects: Cell communication, Mycobacterium smegmatis, Genetic transcription in bacteria, Bacterial mutation, DNA
Abstract: Communal bacterial processes require intercellular communication mediated by secretion systems to coordinate appropriate molecular responses. Intercellular communication has not been described previously in mycobacteria. Here we show that the ESX secretion-system family member ESX-4 is essential for conjugal recipient activity in Mycobacterium smegmatis. Transcription of esx4 genes in the recipient requires coculture with a donor strain and a functional ESX-1 apparatus in the recipient. Conversely, mutation of the donor ESX-1 apparatus amplifies the esx4 transcriptional response in the recipient. The effect of ESX-1 on esx4 transcription correlates with conjugal DNA transfer efficiencies. Our data show that intercellular communication via ESX-1 controls the expression of its evolutionary progenitor, ESX-4, to promote conjugation between mycobacteria. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Intercellular communication and conjugation are mediated by ESX secretion systems in mycobacteria.
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  Data: <searchLink fieldCode="AR" term="%22Gray%2C+Todd+A%2E%22">Gray, Todd A.</searchLink><br /><searchLink fieldCode="AR" term="%22Clark%2C+Ryan+R%2E%22">Clark, Ryan R.</searchLink><br /><searchLink fieldCode="AR" term="%22Boucher%2C+Nathalie%22">Boucher, Nathalie</searchLink><br /><searchLink fieldCode="AR" term="%22Lapierre%2C+Pascal%22">Lapierre, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+Carol%22">Smith, Carol</searchLink><br /><searchLink fieldCode="AR" term="%22Derbyshire%2C+Keith+M%2E%22">Derbyshire, Keith M.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 10/21/2016, Vol. 354 Issue 6310, p347-350. 4p. 1 Diagram, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Cell+communication%22">Cell communication</searchLink><br /><searchLink fieldCode="DE" term="%22Mycobacterium+smegmatis%22">Mycobacterium smegmatis</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+transcription+in+bacteria%22">Genetic transcription in bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial+mutation%22">Bacterial mutation</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink>
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  Label: Abstract
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  Data: Communal bacterial processes require intercellular communication mediated by secretion systems to coordinate appropriate molecular responses. Intercellular communication has not been described previously in mycobacteria. Here we show that the ESX secretion-system family member ESX-4 is essential for conjugal recipient activity in Mycobacterium smegmatis. Transcription of esx4 genes in the recipient requires coculture with a donor strain and a functional ESX-1 apparatus in the recipient. Conversely, mutation of the donor ESX-1 apparatus amplifies the esx4 transcriptional response in the recipient. The effect of ESX-1 on esx4 transcription correlates with conjugal DNA transfer efficiencies. Our data show that intercellular communication via ESX-1 controls the expression of its evolutionary progenitor, ESX-4, to promote conjugation between mycobacteria. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1126/science.aag0828
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        Text: English
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        Type: general
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      – SubjectFull: Genetic transcription in bacteria
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              Text: 10/21/2016
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