View in EDS HTML Full Text PDF Full Text

Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial.

Saved in:
Bibliographic Details
Title: Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial.
Authors: Køber, L (AUTHOR), Bloch Thomsen, P E (AUTHOR), Møller, M (AUTHOR), Torp-Pedersen, C (AUTHOR), Carlsen, J (AUTHOR), Sandøe, E (AUTHOR), Egstrup, K (AUTHOR), Agner, E (AUTHOR), Videbaek, J (AUTHOR), Marchant, B (AUTHOR), Camm, A J (AUTHOR), Danish Investigations of Arrhythmia and Mortality on Dofetilide (DIAMOND) Study Group (CORPORATE AUTHOR)
Source: Lancet. 12/16/2000, Vol. 356 Issue 9247, p2052-2058. 7p.
Subjects: Myocardial infarction complications, Myocardial infarction-related mortality, Sulfonamide drugs, Myocardial depressants, Phenethylamines, Heart ventricle diseases, Atrial fibrillation, Clinical trials, Comparative studies, Left heart ventricle, Research methodology, Medical cooperation, Myocardial infarction, Research, Atrial flutter, Evaluation research, Randomized controlled trials, Blind experiment, Disease complications, Therapeutics
Abstract: Background: Arrhythmias cause much morbidity and mortality after myocardial infarction, but in previous trials, antiarrhythmic drug therapy has not been convincingly effective. Dofetilide, a new class III agent, was investigated for effects on all-cause mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction.Methods: In 37 Danish coronary-care units, 1510 patients with severe left-ventricular dysfunction (wall motion index < or = 1.2, corresponding to ejection fraction < or = 0.35) were enrolled in a randomised, double-blind study comparing dofetilide (n=749) with placebo (n=761). The primary endpoint was all-cause mortality. Secondary endpoints included cardiac and arrhythmic mortality and total arrhythmic deaths. Analyses were by intention to treat.Findings: No significant differences were found between the dofetilide and placebo groups in all-cause mortality (230 [31%] vs 243 [32%]), cardiac mortality (191 [26%] vs 212 [28%]), or total arrhythmic deaths (129 [17%] vs 140 [18%]). Atrial fibrillation or flutter was present in 8% of the patients at study entry. In these patients, dofetilide was significantly better than placebo at restoring sinus rhythm (25 of 59 vs seven of 56; p=0.002). There were seven cases of torsade de pointes ventricular tachycardia, all in the dofetilide group.Interpretation: In patients with severe left-ventricular dysfunction and recent myocardial infarction, treatment with dofetilide did not affect all-cause mortality, cardiac mortality, or total arrhythmic deaths. Dofetilide was effective in treating atrial fibrillation or flutter in this population. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 119724366
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22K&#248;ber%2C+L%22&quot;&gt;K&#248;ber, L&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bloch+Thomsen%2C+P+E%22&quot;&gt;Bloch Thomsen, P E&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22M&#248;ller%2C+M%22&quot;&gt;M&#248;ller, M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Torp-Pedersen%2C+C%22&quot;&gt;Torp-Pedersen, C&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carlsen%2C+J%22&quot;&gt;Carlsen, J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sand&#248;e%2C+E%22&quot;&gt;Sand&#248;e, E&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Egstrup%2C+K%22&quot;&gt;Egstrup, K&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Agner%2C+E%22&quot;&gt;Agner, E&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Videbaek%2C+J%22&quot;&gt;Videbaek, J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marchant%2C+B%22&quot;&gt;Marchant, B&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Camm%2C+A+J%22&quot;&gt;Camm, A J&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Danish+Investigations+of+Arrhythmia+and+Mortality+on+Dofetilide+%28DIAMOND%29+Study+Group%22&quot;&gt;Danish Investigations of Arrhythmia and Mortality on Dofetilide (DIAMOND) Study Group&lt;/searchLink&gt; (CORPORATE AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Lancet%22&quot;&gt;Lancet&lt;/searchLink&gt;. 12/16/2000, Vol. 356 Issue 9247, p2052-2058. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+infarction+complications%22&quot;&gt;Myocardial infarction complications&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+infarction-related+mortality%22&quot;&gt;Myocardial infarction-related mortality&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sulfonamide+drugs%22&quot;&gt;Sulfonamide drugs&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+depressants%22&quot;&gt;Myocardial depressants&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Phenethylamines%22&quot;&gt;Phenethylamines&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Heart+ventricle+diseases%22&quot;&gt;Heart ventricle diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atrial+fibrillation%22&quot;&gt;Atrial fibrillation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Clinical+trials%22&quot;&gt;Clinical trials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Comparative+studies%22&quot;&gt;Comparative studies&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Left+heart+ventricle%22&quot;&gt;Left heart ventricle&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+methodology%22&quot;&gt;Research methodology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+cooperation%22&quot;&gt;Medical cooperation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Myocardial+infarction%22&quot;&gt;Myocardial infarction&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research%22&quot;&gt;Research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Atrial+flutter%22&quot;&gt;Atrial flutter&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Evaluation+research%22&quot;&gt;Evaluation research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Randomized+controlled+trials%22&quot;&gt;Randomized controlled trials&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blind+experiment%22&quot;&gt;Blind experiment&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+complications%22&quot;&gt;Disease complications&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Therapeutics%22&quot;&gt;Therapeutics&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Background: &lt;/bold&gt;Arrhythmias cause much morbidity and mortality after myocardial infarction, but in previous trials, antiarrhythmic drug therapy has not been convincingly effective. Dofetilide, a new class III agent, was investigated for effects on all-cause mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction.&lt;bold&gt;Methods: &lt;/bold&gt;In 37 Danish coronary-care units, 1510 patients with severe left-ventricular dysfunction (wall motion index &lt; or = 1.2, corresponding to ejection fraction &lt; or = 0.35) were enrolled in a randomised, double-blind study comparing dofetilide (n=749) with placebo (n=761). The primary endpoint was all-cause mortality. Secondary endpoints included cardiac and arrhythmic mortality and total arrhythmic deaths. Analyses were by intention to treat.&lt;bold&gt;Findings: &lt;/bold&gt;No significant differences were found between the dofetilide and placebo groups in all-cause mortality (230 [31%] vs 243 [32%]), cardiac mortality (191 [26%] vs 212 [28%]), or total arrhythmic deaths (129 [17%] vs 140 [18%]). Atrial fibrillation or flutter was present in 8% of the patients at study entry. In these patients, dofetilide was significantly better than placebo at restoring sinus rhythm (25 of 59 vs seven of 56; p=0.002). There were seven cases of torsade de pointes ventricular tachycardia, all in the dofetilide group.&lt;bold&gt;Interpretation: &lt;/bold&gt;In patients with severe left-ventricular dysfunction and recent myocardial infarction, treatment with dofetilide did not affect all-cause mortality, cardiac mortality, or total arrhythmic deaths. Dofetilide was effective in treating atrial fibrillation or flutter in this population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=119724366
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/s0140-6736(00)03402-4
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 2052
    Subjects:
      – SubjectFull: Myocardial infarction complications
        Type: general
      – SubjectFull: Myocardial infarction-related mortality
        Type: general
      – SubjectFull: Sulfonamide drugs
        Type: general
      – SubjectFull: Myocardial depressants
        Type: general
      – SubjectFull: Phenethylamines
        Type: general
      – SubjectFull: Heart ventricle diseases
        Type: general
      – SubjectFull: Atrial fibrillation
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Left heart ventricle
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Myocardial infarction
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Atrial flutter
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Blind experiment
        Type: general
      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Therapeutics
        Type: general
    Titles:
      – TitleFull: Effect of dofetilide in patients with recent myocardial infarction and left-ventricular dysfunction: a randomised trial.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Køber, L
      – PersonEntity:
          Name:
            NameFull: Bloch Thomsen, P E
      – PersonEntity:
          Name:
            NameFull: Møller, M
      – PersonEntity:
          Name:
            NameFull: Torp-Pedersen, C
      – PersonEntity:
          Name:
            NameFull: Carlsen, J
      – PersonEntity:
          Name:
            NameFull: Sandøe, E
      – PersonEntity:
          Name:
            NameFull: Egstrup, K
      – PersonEntity:
          Name:
            NameFull: Agner, E
      – PersonEntity:
          Name:
            NameFull: Videbaek, J
      – PersonEntity:
          Name:
            NameFull: Marchant, B
      – PersonEntity:
          Name:
            NameFull: Camm, A J
      – PersonEntity:
          Name:
            NameFull: Danish Investigations of Arrhythmia and Mortality on Dofetilide (DIAMOND) Study Group
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 16
              M: 12
              Text: 12/16/2000
              Type: published
              Y: 2000
          Identifiers:
            – Type: issn-print
              Value: 01406736
          Numbering:
            – Type: volume
              Value: 356
            – Type: issue
              Value: 9247
          Titles:
            – TitleFull: Lancet
              Type: main
ResultId 1