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Mesial temporal lobe epilepsy with childhood febrile seizure.

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Title: Mesial temporal lobe epilepsy with childhood febrile seizure.
Authors: Asadi‐Pooya, A. A., Nei, M., Rostami, C., Sperling, M. R.
Source: Acta Neurologica Scandinavica. Jan2017, Vol. 135 Issue 1, p88-91. 4p.
Subjects: Temporal lobe epilepsy, Febrile seizures, Drug resistance, Medical databases, Pediatric surgery, History of medicine
Abstract: Objectives To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy ( MTS- TLE) with childhood febrile seizure ( FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients. Materials and methods In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. Clinical manifestations and outcome were compared between patients with MTS- TLE with FS and those without FS. Results Two hundred and sixty-two patients were eligible for this study. One hundred and seventy patients (64.9%) did not have FS in their childhood, while 92 patients (35.1%) reported experiencing FS in their childhood. Demographic and clinical characteristics of these two groups of patients were not different. Postoperative seizure outcome was not statistically different between these two groups of patients ( P = 0.19). Conclusions When MTS is the pathological substrate of TLE, clinical manifestations and response to surgical treatment of patients are very similar in patients with history of febrile seizure in their childhood compared to those without such an experience. In other words, when the subgroup of patients with MTS- TLE and drug-resistant seizures is examined history of childhood febrile seizure loses its value as a distinguishing factor in characteristics or predictive factor for surgery outcome. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Mesial temporal lobe epilepsy with childhood febrile seizure.
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  Data: <searchLink fieldCode="AR" term="%22Asadi‐Pooya%2C+A%2E+A%2E%22">Asadi‐Pooya, A. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Nei%2C+M%2E%22">Nei, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Rostami%2C+C%2E%22">Rostami, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Sperling%2C+M%2E+R%2E%22">Sperling, M. R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jan2017, Vol. 135 Issue 1, p88-91. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Temporal+lobe+epilepsy%22">Temporal lobe epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Febrile+seizures%22">Febrile seizures</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+databases%22">Medical databases</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatric+surgery%22">Pediatric surgery</searchLink><br /><searchLink fieldCode="DE" term="%22History+of+medicine%22">History of medicine</searchLink>
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  Label: Abstract
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  Data: Objectives To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy ( MTS- TLE) with childhood febrile seizure ( FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients. Materials and methods In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. Clinical manifestations and outcome were compared between patients with MTS- TLE with FS and those without FS. Results Two hundred and sixty-two patients were eligible for this study. One hundred and seventy patients (64.9%) did not have FS in their childhood, while 92 patients (35.1%) reported experiencing FS in their childhood. Demographic and clinical characteristics of these two groups of patients were not different. Postoperative seizure outcome was not statistically different between these two groups of patients ( P = 0.19). Conclusions When MTS is the pathological substrate of TLE, clinical manifestations and response to surgical treatment of patients are very similar in patients with history of febrile seizure in their childhood compared to those without such an experience. In other words, when the subgroup of patients with MTS- TLE and drug-resistant seizures is examined history of childhood febrile seizure loses its value as a distinguishing factor in characteristics or predictive factor for surgery outcome. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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