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Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?

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Title: Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?
Authors: Bonavita, S., Sacco, R., Esposito, S., d'Ambrosio, A., Della Corte, M., Corbo, D., Docimo, R., Gallo, A., Lavorgna, L., Cirillo, M., Bisecco, A., Esposito, F., Tedeschi, G.
Source: European Journal of Neurology. Jan2017, Vol. 24 Issue 1, p27-36. 10p.
Subjects: Cognition disorders research, Multiple sclerosis, Mental depression, Pathological physiology, Cingulate cortex, Neuropsychological tests, Patients
Abstract: Background and purpose In multiple sclerosis ( MS), depression is a common disorder whose pathophysiology is still debated. To gain insights into the pathophysiology of depression in MS, resting-state ( RS) functional connectivity ( FC) changes of the default mode network ( DMN), salience network ( SN) and executive control network ( ECN) were assessed in a group of depressed MS (D- MS) patients and in appropriately matched control groups. Methods Sixteen D- MS patients, 17 non-depressed MS ( ND- MS) patients, 17 non-depressed healthy controls and 15 depressed subjects (D-S), age, sex and education matched, cognitively preserved and non-fatigued, were enrolled. All participants underwent a neuropsychological evaluation and RS functional magnetic resonance imaging study. Results Comparing D- MS patients with D-S, within the DMN, a significant RS- FC suppression was found in the posterior cingulate cortex ( PCC); comparing D- MS with ND- MS, FC was significantly increased in the anterior cingulate cortex and significantly reduced in the PCC. Within the SN increased FC in the right supramarginal gyrus and right middle frontal gyrus was found in D- MS patients compared to D-S and to ND- MS; within the ECN increased FC in the right inferior parietal cortex was found in D- MS patients compared to ND- MS patients. Conclusions In cognitively preserved D- MS patients, FC derangement occurs in the SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate cortex and PCC suggest that depression in MS may be linked to MS itself and, in particular, to a peculiar pattern of network abnormalities favored by MS pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS patients with cognitive impairment, suggests a functional link between depression and cognitive impairment in MS. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Default mode network changes in multiple sclerosis: a link between depression and cognitive impairment?
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  Data: <searchLink fieldCode="AR" term="%22Bonavita%2C+S%2E%22">Bonavita, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sacco%2C+R%2E%22">Sacco, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Esposito%2C+S%2E%22">Esposito, S.</searchLink><br /><searchLink fieldCode="AR" term="%22d'Ambrosio%2C+A%2E%22">d'Ambrosio, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Della+Corte%2C+M%2E%22">Della Corte, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Corbo%2C+D%2E%22">Corbo, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Docimo%2C+R%2E%22">Docimo, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Gallo%2C+A%2E%22">Gallo, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Lavorgna%2C+L%2E%22">Lavorgna, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Cirillo%2C+M%2E%22">Cirillo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bisecco%2C+A%2E%22">Bisecco, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Esposito%2C+F%2E%22">Esposito, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Tedeschi%2C+G%2E%22">Tedeschi, G.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Jan2017, Vol. 24 Issue 1, p27-36. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Cognition+disorders+research%22">Cognition disorders research</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychological+tests%22">Neuropsychological tests</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Background and purpose In multiple sclerosis ( MS), depression is a common disorder whose pathophysiology is still debated. To gain insights into the pathophysiology of depression in MS, resting-state ( RS) functional connectivity ( FC) changes of the default mode network ( DMN), salience network ( SN) and executive control network ( ECN) were assessed in a group of depressed MS (D- MS) patients and in appropriately matched control groups. Methods Sixteen D- MS patients, 17 non-depressed MS ( ND- MS) patients, 17 non-depressed healthy controls and 15 depressed subjects (D-S), age, sex and education matched, cognitively preserved and non-fatigued, were enrolled. All participants underwent a neuropsychological evaluation and RS functional magnetic resonance imaging study. Results Comparing D- MS patients with D-S, within the DMN, a significant RS- FC suppression was found in the posterior cingulate cortex ( PCC); comparing D- MS with ND- MS, FC was significantly increased in the anterior cingulate cortex and significantly reduced in the PCC. Within the SN increased FC in the right supramarginal gyrus and right middle frontal gyrus was found in D- MS patients compared to D-S and to ND- MS; within the ECN increased FC in the right inferior parietal cortex was found in D- MS patients compared to ND- MS patients. Conclusions In cognitively preserved D- MS patients, FC derangement occurs in the SN, ECN and DMN. In the latter, changes occurring both in the anterior cingulate cortex and PCC suggest that depression in MS may be linked to MS itself and, in particular, to a peculiar pattern of network abnormalities favored by MS pathology through disconnection mechanisms. Reduced FC in the PCC, similar to MS patients with cognitive impairment, suggests a functional link between depression and cognitive impairment in MS. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=120306530
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