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Telomere length and depression: prospective cohort study and Mendelian randomisation study in 67 306 individuals.

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Title: Telomere length and depression: prospective cohort study and Mendelian randomisation study in 67 306 individuals.
Authors: Wium-Andersen, Marie Kim, Ørsted, David Dynnes, Rode, Line, Bojesen, Stig Egil, Nordestgaard, Børge Grønne
Source: British Journal of Psychiatry. Jan2017, Vol. 210 Issue 1, p31-38. 8p.
Subjects: Telomeres, Mental depression, Antidepressants, Disease prevalence, Randomization (Statistics), Cellular aging, Longitudinal method, Statistical sampling, Randomized controlled trials, Acquisition of data, Cross-sectional method
Geographic Terms: Denmark
Abstract: Background: Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear.Aims: We examined whether short telomere length is associated with depression cross-sectionally as well as prospectively and genetically.Method: Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.Results: Attendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0.0-21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication.Conclusions: Short telomeres were not associated with depression in prospective or in causal, genetic analyses. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Telomere length and depression: prospective cohort study and Mendelian randomisation study in 67 306 individuals.
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  Data: <searchLink fieldCode="AR" term="%22Wium-Andersen%2C+Marie+Kim%22">Wium-Andersen, Marie Kim</searchLink><br /><searchLink fieldCode="AR" term="%22Ørsted%2C+David+Dynnes%22">Ørsted, David Dynnes</searchLink><br /><searchLink fieldCode="AR" term="%22Rode%2C+Line%22">Rode, Line</searchLink><br /><searchLink fieldCode="AR" term="%22Bojesen%2C+Stig+Egil%22">Bojesen, Stig Egil</searchLink><br /><searchLink fieldCode="AR" term="%22Nordestgaard%2C+Børge+Grønne%22">Nordestgaard, Børge Grønne</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jan2017, Vol. 210 Issue 1, p31-38. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Telomeres%22">Telomeres</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Randomization+%28Statistics%29%22">Randomization (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+aging%22">Cellular aging</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Acquisition+of+data%22">Acquisition of data</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Denmark%22">Denmark</searchLink>
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  Data: <bold>Background: </bold>Depression has been cross-sectionally associated with short telomeres as a measure of biological age. However, the direction and nature of the association is currently unclear.<bold>Aims: </bold>We examined whether short telomere length is associated with depression cross-sectionally as well as prospectively and genetically.<bold>Method: </bold>Telomere length and three polymorphisms, TERT, TERC and OBFC1, were measured in 67 306 individuals aged 20-100 years from the Danish general population and associated with register-based attendance at hospital for depression and purchase of antidepressant medication.<bold>Results: </bold>Attendance at hospital for depression was associated with short telomere length cross-sectionally, but not prospectively. Further, purchase of antidepressant medication was not associated with short telomere length cross-sectionally or prospectively. Mean follow-up was 7.6 years (range 0.0-21.5). The genetic analyses suggested that telomere length was not causally associated with attendance at hospital for depression or with purchase of antidepressant medication.<bold>Conclusions: </bold>Short telomeres were not associated with depression in prospective or in causal, genetic analyses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=120703660
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      – Type: doi
        Value: 10.1192/bjp.bp.115.178798
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 31
    Subjects:
      – SubjectFull: Telomeres
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Disease prevalence
        Type: general
      – SubjectFull: Randomization (Statistics)
        Type: general
      – SubjectFull: Cellular aging
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Statistical sampling
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      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Acquisition of data
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      – SubjectFull: Cross-sectional method
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      – SubjectFull: Denmark
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      – TitleFull: Telomere length and depression: prospective cohort study and Mendelian randomisation study in 67 306 individuals.
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            NameFull: Wium-Andersen, Marie Kim
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            – D: 01
              M: 01
              Text: Jan2017
              Type: published
              Y: 2017
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              Value: 210
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