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Hippocampal volume in patients with asthma: Results from the Dallas Heart Study.

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Title: Hippocampal volume in patients with asthma: Results from the Dallas Heart Study.
Authors: Carlson, Scott M. (AUTHOR), Kim, Julie (AUTHOR), Khan, David A. (AUTHOR), King, Kevin (AUTHOR), Lucarelli, Richard T. (AUTHOR), McColl, Roderick (AUTHOR), Peshock, Ronald (AUTHOR), Brown, E. Sherwood (AUTHOR)
Source: Journal of Asthma. 2017, Vol. 54 Issue 1, p9-16. 8p.
Subjects: Asthma diagnosis, Cognition disorder risk factors, Mild cognitive impairment, Asthma treatment, Hippocampus physiology
Geographic Terms: Dallas (Tex.)
Abstract: Introduction:Asthma is associated with an increased risk of mild cognitive impairment and dementia. Depression and oral corticosteroid use are associated with atrophy of the hippocampus and are common in asthma. However, minimal neuroimaging data are available in asthma patients.Methods:We conducted a retrospective analysis of 1,287 adult participants from the Dallas Heart Study, an epidemiological sample of Dallas County residents. Study outcome variables were hippocampal volumes measured by FreeSurfer. ANOVA was used to examine a gender difference in hippocampal volumes. General Linear Models (GLM) were conducted to examine asthma diagnosis association with hippocampal volumes.Results:The prevalence rate of asthma among our study sample was 10.8% with 9.6% in males and 11.7% in females. After controlling for demographic characteristics, participants with asthma had significantly smaller total, right, and left hippocampal volumes than those without asthma. The association of asthma with smaller hippocampal volume was significant among males but not among females.Conclusion:Hippocampal volume in a large and diverse sample of adults was significantly smaller in people with asthma as compared to those without asthma. These findings suggest that asthma may be associated with structural brain differences. Thus, medical illnesses without obvious direct neurodegenerative or even vascular involvement can be associated with brain changes. Because the hippocampus is a brain region involved in memory formation, these findings may have implications for treatment adherence that could have important implications for asthma treatment. Study limitations are the reliance on a self-reported asthma diagnosis and lack of additional asthma clinical information. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Hippocampal volume in patients with asthma: Results from the Dallas Heart Study.
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  Data: <searchLink fieldCode="AR" term="%22Carlson%2C+Scott+M%2E%22">Carlson, Scott M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Julie%22">Kim, Julie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Khan%2C+David+A%2E%22">Khan, David A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22King%2C+Kevin%22">King, Kevin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lucarelli%2C+Richard+T%2E%22">Lucarelli, Richard T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McColl%2C+Roderick%22">McColl, Roderick</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peshock%2C+Ronald%22">Peshock, Ronald</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brown%2C+E%2E+Sherwood%22">Brown, E. Sherwood</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. 2017, Vol. 54 Issue 1, p9-16. 8p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Asthma+diagnosis%22">Asthma diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+disorder+risk+factors%22">Cognition disorder risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma+treatment%22">Asthma treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+physiology%22">Hippocampus physiology</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Dallas+%28Tex%2E%29%22">Dallas (Tex.)</searchLink>
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  Label: Abstract
  Group: Ab
  Data: Introduction:Asthma is associated with an increased risk of mild cognitive impairment and dementia. Depression and oral corticosteroid use are associated with atrophy of the hippocampus and are common in asthma. However, minimal neuroimaging data are available in asthma patients.Methods:We conducted a retrospective analysis of 1,287 adult participants from the Dallas Heart Study, an epidemiological sample of Dallas County residents. Study outcome variables were hippocampal volumes measured by FreeSurfer. ANOVA was used to examine a gender difference in hippocampal volumes. General Linear Models (GLM) were conducted to examine asthma diagnosis association with hippocampal volumes.Results:The prevalence rate of asthma among our study sample was 10.8% with 9.6% in males and 11.7% in females. After controlling for demographic characteristics, participants with asthma had significantly smaller total, right, and left hippocampal volumes than those without asthma. The association of asthma with smaller hippocampal volume was significant among males but not among females.Conclusion:Hippocampal volume in a large and diverse sample of adults was significantly smaller in people with asthma as compared to those without asthma. These findings suggest that asthma may be associated with structural brain differences. Thus, medical illnesses without obvious direct neurodegenerative or even vascular involvement can be associated with brain changes. Because the hippocampus is a brain region involved in memory formation, these findings may have implications for treatment adherence that could have important implications for asthma treatment. Study limitations are the reliance on a self-reported asthma diagnosis and lack of additional asthma clinical information. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/02770903.2016.1186174
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        Text: English
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        PageCount: 8
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      – SubjectFull: Asthma diagnosis
        Type: general
      – SubjectFull: Cognition disorder risk factors
        Type: general
      – SubjectFull: Mild cognitive impairment
        Type: general
      – SubjectFull: Asthma treatment
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      – SubjectFull: Hippocampus physiology
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      – SubjectFull: Dallas (Tex.)
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      – TitleFull: Hippocampal volume in patients with asthma: Results from the Dallas Heart Study.
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              Text: 2017
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