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Recent viral infection in US blood donors and health-related quality of life (HRQOL).

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Title: Recent viral infection in US blood donors and health-related quality of life (HRQOL).
Authors: Vahidnia, Farnaz, Stramer, Susan, Kessler, Debra, Shaz, Beth, Leparc, German, Krysztof, David, Glynn, Simone, Custer, Brian, Stramer, Susan L (AUTHOR), Krysztof, David E (AUTHOR), Glynn, Simone A (AUTHOR)
Source: Quality of Life Research. Feb2017, Vol. 26 Issue 2, p349-357. 9p.
Subjects: Virus diseases, Blood donors, Quality of life, HTLV, Medical informatics, Questionnaires, Sickness Impact Profile, Psychology
Abstract: Purpose: Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group.Methods: Donors with confirmed viral infection (cases) and donors who tested false-positive (controls) participated in a multicenter study of US blood donors (2010-2013), funded by the National Heart, Lung and Blood Institute (NHLBI). HRQOL was measured by the EuroQol Five Dimension (EQ-5D) instrument and EQ-5D visual analogue scale (VAS). The lower 25th ‰ of EQ-5D index or VAS score of controls was defined as a "lower HRQOL."Results: A total of 1574 controls completed the HRQOL assessment with a mean EQ-5D index of 0.94 (SD = 0.10) and EQ-VAS of 87.6 (SD = 10.6). Mean EQ-5D index for 192 HIV-, 315 HCV- and 195 HTLV-positive donors were significantly lower than the controls (0.86, 0.83 and 0.87; SD = 0.18, 0.20 and 0.16, respectively, p < 0.001). HBV-positive donors (n = 290) had a similar mean EQ-5D index (0.93, SD = 0.14, p = 0.05) to controls. Anxiety/depression was reported by 34 % of cases, compared with 13 % of controls. In multivariable modeling, the odds of lower HRQOL in HIV, HBV, HCV and HTLV cases were 2.1, 1.6, 2.6 and 2.3 times that of controls, respectively (p < 0.05).Conclusions: HRQOL reported by blood donors with recent viral infections was relatively high but lower than controls. On average, HRQOL among HCV-positive donors was the lowest and HBV-positive donors reported scores similar to donors without infection. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Recent viral infection in US blood donors and health-related quality of life (HRQOL).
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vahidnia%2C+Farnaz%22&quot;&gt;Vahidnia, Farnaz&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stramer%2C+Susan%22&quot;&gt;Stramer, Susan&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kessler%2C+Debra%22&quot;&gt;Kessler, Debra&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shaz%2C+Beth%22&quot;&gt;Shaz, Beth&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Leparc%2C+German%22&quot;&gt;Leparc, German&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Krysztof%2C+David%22&quot;&gt;Krysztof, David&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Glynn%2C+Simone%22&quot;&gt;Glynn, Simone&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Custer%2C+Brian%22&quot;&gt;Custer, Brian&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Stramer%2C+Susan+L%22&quot;&gt;Stramer, Susan L&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Krysztof%2C+David+E%22&quot;&gt;Krysztof, David E&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Glynn%2C+Simone+A%22&quot;&gt;Glynn, Simone A&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Quality+of+Life+Research%22&quot;&gt;Quality of Life Research&lt;/searchLink&gt;. Feb2017, Vol. 26 Issue 2, p349-357. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Virus+diseases%22&quot;&gt;Virus diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+donors%22&quot;&gt;Blood donors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Quality+of+life%22&quot;&gt;Quality of life&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22HTLV%22&quot;&gt;HTLV&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+informatics%22&quot;&gt;Medical informatics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Questionnaires%22&quot;&gt;Questionnaires&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sickness+Impact+Profile%22&quot;&gt;Sickness Impact Profile&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychology%22&quot;&gt;Psychology&lt;/searchLink&gt;
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  Data: &lt;bold&gt;Purpose: &lt;/bold&gt;Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group.&lt;bold&gt;Methods: &lt;/bold&gt;Donors with confirmed viral infection (cases) and donors who tested false-positive (controls) participated in a multicenter study of US blood donors (2010-2013), funded by the National Heart, Lung and Blood Institute (NHLBI). HRQOL was measured by the EuroQol Five Dimension (EQ-5D) instrument and EQ-5D visual analogue scale (VAS). The lower 25th ‰ of EQ-5D index or VAS score of controls was defined as a &quot;lower HRQOL.&quot;&lt;bold&gt;Results: &lt;/bold&gt;A total of 1574 controls completed the HRQOL assessment with a mean EQ-5D index of 0.94 (SD&#160;=&#160;0.10) and EQ-VAS of 87.6 (SD&#160;=&#160;10.6). Mean EQ-5D index for 192 HIV-, 315 HCV- and 195 HTLV-positive donors were significantly lower than the controls (0.86, 0.83 and 0.87; SD&#160;=&#160;0.18, 0.20 and 0.16, respectively, p&#160;&lt;&#160;0.001). HBV-positive donors (n&#160;=&#160;290) had a similar mean EQ-5D index (0.93, SD&#160;=&#160;0.14, p&#160;=&#160;0.05) to controls. Anxiety/depression was reported by 34&#160;% of cases, compared with 13&#160;% of controls. In multivariable modeling, the odds of lower HRQOL in HIV, HBV, HCV and HTLV cases were 2.1, 1.6, 2.6 and 2.3 times that of controls, respectively (p&#160;&lt;&#160;0.05).&lt;bold&gt;Conclusions: &lt;/bold&gt;HRQOL reported by blood donors with recent viral infections was relatively high but lower than controls. On average, HRQOL among HCV-positive donors was the lowest and HBV-positive donors reported scores similar to donors without infection. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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