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Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus.

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Title: Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus.
Authors: Meletti, Stefano, Lucchi, Chiara, Monti, Giulia, Giovannini, Giada, Bedin, Roberta, Trenti, Tommaso, Rustichelli, Cecilia, Biagini, Giuseppe
Source: Epilepsia (Series 4). Feb2017, Vol. 58 Issue 2, pe16-e20. 5p.
Subjects: Pregnanolone, Cerebrospinal fluid, Status epilepticus, Anticonvulsants, Liquid chromatography
Abstract: Neuroactive steroids are increasingly considered as relevant modulators of neuronal activity. Especially allopregnanolone ( AP) and pregnenolone sulfate ( PS) have been shown to possess, respectively, anticonvulsant or proconvulsant properties. In view of the potential role of these steroids, we aimed at evaluating AP and PS levels in cerebrospinal fluid ( CSF) and blood samples obtained from patients with status epilepticus ( SE). To this purpose, we enrolled 41 patients affected by SE and 41 subjects investigated for nonepileptic neurologic disorders. Liquid chromatographic procedures coupled with electrospray tandem mass spectrometry and routine laboratory investigations were performed. Significantly lower AP levels were found in the CSF of patients affected by SE (−30%; p < 0.05, Mann-Whitney test). Notably, AP was not detectable in 28 of 41 patients affected by SE (p < 0.01 vs. controls, Fisher's exact test). In serum, AP levels did not differ in the two considered groups. Conversely, PS was present at similar levels in the investigated groups. Finally, differences in AP levels could not be explained by a variation in CSF albumin content. These findings indicate that AP is defective in the CSF of patients affected by SE. This phenomenon was not dependent on carriers for steroids, such as albumin. [ABSTRACT FROM AUTHOR]
Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meletti%2C+Stefano%22&quot;&gt;Meletti, Stefano&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lucchi%2C+Chiara%22&quot;&gt;Lucchi, Chiara&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Monti%2C+Giulia%22&quot;&gt;Monti, Giulia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Giovannini%2C+Giada%22&quot;&gt;Giovannini, Giada&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bedin%2C+Roberta%22&quot;&gt;Bedin, Roberta&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Trenti%2C+Tommaso%22&quot;&gt;Trenti, Tommaso&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rustichelli%2C+Cecilia%22&quot;&gt;Rustichelli, Cecilia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Biagini%2C+Giuseppe%22&quot;&gt;Biagini, Giuseppe&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Epilepsia+%28Series+4%29%22&quot;&gt;Epilepsia (Series 4)&lt;/searchLink&gt;. Feb2017, Vol. 58 Issue 2, pe16-e20. 5p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Pregnanolone%22&quot;&gt;Pregnanolone&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebrospinal+fluid%22&quot;&gt;Cerebrospinal fluid&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Status+epilepticus%22&quot;&gt;Status epilepticus&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Anticonvulsants%22&quot;&gt;Anticonvulsants&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Liquid+chromatography%22&quot;&gt;Liquid chromatography&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Neuroactive steroids are increasingly considered as relevant modulators of neuronal activity. Especially allopregnanolone ( AP) and pregnenolone sulfate ( PS) have been shown to possess, respectively, anticonvulsant or proconvulsant properties. In view of the potential role of these steroids, we aimed at evaluating AP and PS levels in cerebrospinal fluid ( CSF) and blood samples obtained from patients with status epilepticus ( SE). To this purpose, we enrolled 41 patients affected by SE and 41 subjects investigated for nonepileptic neurologic disorders. Liquid chromatographic procedures coupled with electrospray tandem mass spectrometry and routine laboratory investigations were performed. Significantly lower AP levels were found in the CSF of patients affected by SE (−30%; p &lt; 0.05, Mann-Whitney test). Notably, AP was not detectable in 28 of 41 patients affected by SE (p &lt; 0.01 vs. controls, Fisher&#39;s exact test). In serum, AP levels did not differ in the two considered groups. Conversely, PS was present at similar levels in the investigated groups. Finally, differences in AP levels could not be explained by a variation in CSF albumin content. These findings indicate that AP is defective in the CSF of patients affected by SE. This phenomenon was not dependent on carriers for steroids, such as albumin. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Epilepsia (Series 4) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=121082074
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/epi.13625
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: e16
    Subjects:
      – SubjectFull: Pregnanolone
        Type: general
      – SubjectFull: Cerebrospinal fluid
        Type: general
      – SubjectFull: Status epilepticus
        Type: general
      – SubjectFull: Anticonvulsants
        Type: general
      – SubjectFull: Liquid chromatography
        Type: general
    Titles:
      – TitleFull: Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus.
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            NameFull: Meletti, Stefano
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            NameFull: Lucchi, Chiara
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            NameFull: Monti, Giulia
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            NameFull: Bedin, Roberta
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            NameFull: Trenti, Tommaso
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            – D: 01
              M: 02
              Text: Feb2017
              Type: published
              Y: 2017
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              Value: 00139580
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