Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS).
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| Title: | Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS). |
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| Authors: | Meyer, Thomas, Becker, Andreas, Sundermann, Jessika, Rothenberger, Aribert, Herrmann-Lingen, Christoph |
| Source: | European Child & Adolescent Psychiatry. Feb2017, Vol. 26 Issue 2, p165-175. 11p. |
| Subjects: | Analysis of variance, Attention-deficit hyperactivity disorder, Blood pressure, Blood pressure measurement, Chi-squared test, Confidence intervals, Statistical correlation, Hyperkinesia, Hypotension, Questionnaires, Regression analysis, Research funding, Statistics, T-test (Statistics), Vitamin D, Vitamin D deficiency, Logistic regression analysis, Data analysis, Body mass index, Data analysis software |
| Geographic Terms: | Germany |
| Abstract: | Alterations in blood pressure in attention-deficit/hyperactivity disorder (ADHD), specifically during dopaminergic stimulant intake, are not fully understood. It has been reported that vitamin D deficiency might modify dopaminergic pathways and thus influence ADHD symptoms. Using data from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study, we compared blood pressure and vitamin D levels in healthy controls to both diagnosed ADHD patients and suspected ADHD subjects, as defined by a value of ≥7 on the hyperactivity-inattention subscale of the Strengths and Difficulties Questionnaire. In a total cohort of n = 6922 study participants aged 11-17 years, mean arterial blood pressure was significantly higher in controls (86.7 ± 8.2 mmHg) than in the two groups of confirmed (85.5 ± 7.8 mmHg, p = 0.004, n = 430) and suspected ADHD patients (84.6 ± 8.2, p < 0.001, n = 399). In addition, we found an inverse association between vitamin D and blood pressure in both ADHD groups ( p < 0.003). Regression analyses adjusted for age, sex, body-mass index, psychotropic medication use, and serum vitamin D levels confirmed that low blood pressure was a significant and independent predictor of ADHD. Furthermore, we observed that vitamin D mediated the effect of systolic blood pressure on ADHD diagnosis ( b = 0.007, 95 % confidence interval [CI] 0.001-0.013, p = 0.021, R = 0.050). In a large and representative national sample of German adolescents, we found a significant association between low blood pressure and ADHD symptoms. In addition, we observed that circulating vitamin D mediated the inverse relation between blood pressure and ADHD, although the effect size was very low. These findings highlight the role of dysregulated pathways of the autonomic nervous system in ADHD. [ABSTRACT FROM AUTHOR] |
| Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 121185759 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Meyer%2C+Thomas%22">Meyer, Thomas</searchLink><br /><searchLink fieldCode="AR" term="%22Becker%2C+Andreas%22">Becker, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Sundermann%2C+Jessika%22">Sundermann, Jessika</searchLink><br /><searchLink fieldCode="AR" term="%22Rothenberger%2C+Aribert%22">Rothenberger, Aribert</searchLink><br /><searchLink fieldCode="AR" term="%22Herrmann-Lingen%2C+Christoph%22">Herrmann-Lingen, Christoph</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Child+%26+Adolescent+Psychiatry%22">European Child & Adolescent Psychiatry</searchLink>. 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It has been reported that vitamin D deficiency might modify dopaminergic pathways and thus influence ADHD symptoms. Using data from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS) study, we compared blood pressure and vitamin D levels in healthy controls to both diagnosed ADHD patients and suspected ADHD subjects, as defined by a value of ≥7 on the hyperactivity-inattention subscale of the Strengths and Difficulties Questionnaire. In a total cohort of n = 6922 study participants aged 11-17 years, mean arterial blood pressure was significantly higher in controls (86.7 ± 8.2 mmHg) than in the two groups of confirmed (85.5 ± 7.8 mmHg, p = 0.004, n = 430) and suspected ADHD patients (84.6 ± 8.2, p < 0.001, n = 399). In addition, we found an inverse association between vitamin D and blood pressure in both ADHD groups ( p < 0.003). Regression analyses adjusted for age, sex, body-mass index, psychotropic medication use, and serum vitamin D levels confirmed that low blood pressure was a significant and independent predictor of ADHD. Furthermore, we observed that vitamin D mediated the effect of systolic blood pressure on ADHD diagnosis ( b = 0.007, 95 % confidence interval [CI] 0.001-0.013, p = 0.021, R = 0.050). In a large and representative national sample of German adolescents, we found a significant association between low blood pressure and ADHD symptoms. In addition, we observed that circulating vitamin D mediated the inverse relation between blood pressure and ADHD, although the effect size was very low. These findings highlight the role of dysregulated pathways of the autonomic nervous system in ADHD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00787-016-0852-3 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 165 Subjects: – SubjectFull: Analysis of variance Type: general – SubjectFull: Attention-deficit hyperactivity disorder Type: general – SubjectFull: Blood pressure Type: general – SubjectFull: Blood pressure measurement Type: general – SubjectFull: Chi-squared test Type: general – SubjectFull: Confidence intervals Type: general – SubjectFull: Statistical correlation Type: general – SubjectFull: Hyperkinesia Type: general – SubjectFull: Hypotension Type: general – SubjectFull: Questionnaires Type: general – SubjectFull: Regression analysis Type: general – SubjectFull: Research funding Type: general – SubjectFull: Statistics Type: general – SubjectFull: T-test (Statistics) Type: general – SubjectFull: Vitamin D Type: general – SubjectFull: Vitamin D deficiency Type: general – SubjectFull: Logistic regression analysis Type: general – SubjectFull: Data analysis Type: general – SubjectFull: Body mass index Type: general – SubjectFull: Data analysis software Type: general – SubjectFull: Germany Type: general Titles: – TitleFull: Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Meyer, Thomas – PersonEntity: Name: NameFull: Becker, Andreas – PersonEntity: Name: NameFull: Sundermann, Jessika – PersonEntity: Name: NameFull: Rothenberger, Aribert – PersonEntity: Name: NameFull: Herrmann-Lingen, Christoph IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 10188827 Numbering: – Type: volume Value: 26 – Type: issue Value: 2 Titles: – TitleFull: European Child & Adolescent Psychiatry Type: main |
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